A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit
| Main Author: | |
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| Publication Date: | 2020 |
| Other Authors: | , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10451/46271 |
Summary: | Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbitEuropean rabbitOryctolagus cuniculusPet rabbitRabbit haemorrhagic diseaseAtypical clinical courseSubacuteCopyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Rabbit haemorrhagic disease (RHD) is a highly contagious infectious disease of European wild and domestic rabbits. Rabbit haemorrhagic disease virus (RHDV, GI.1) emerged in 1986 in Europe, rapidly spreading all over the world. Several genotypes of RHDV have been recognised over time, but in 2010, a new virus (RHDV2/RHDVb, GI.2) emerged and progressively replaced the previous RHDV strains, due to the lack of cross-immunity conferred between RHDV and RHDV2. RHDV2 has a high mutation rate, similarly to the other calivirus and recombines with strains of RHDV and non-pathogenic calicivirus (GI.4), ensuring the continuous emergence of new field strains. Although this poses a threat to the already endangered European rabbit species, the available vaccines against RHDV2 and the compliance of biosafety measures seem to be controlling the infection in the rabbit industry Pet rabbits, especially when kept indoor, are considered at lower risk of infections, although RHDV2 and myxoma virus (MYXV) constitute a permanent threat due to transmission via insects. Vaccination against these viruses is therefore recommended every 6 months (myxomatosis) or annually (rabbit haemorrhagic disease). The combined immunization for myxomatosis and RHDV through a commercially available bivalent vaccine with RHDV antigen has been extensively used (Nobivac® Myxo-RHD, MSD, Kenilworth, NJ, USA). This vaccine however does not confer proper protection against the RHDV2, thus the need for a rabbit clinical vaccination protocol update. Here we report a clinical case of hepatitis and alteration of coagulation in a pet rabbit that had been vaccinated with the commercially available bivalent vaccine against RHDV and tested positive to RHDV2 after death. The animal developed a prolonged and atypical disease, compatible with RHD. The virus was identified to be an RHDV2 recombinant strain, with the structural backbone of RHDV2 (GI.2) and the non-structural genes of non-pathogenic-A1 strains (RCV-A1, GI.4). Although confirmation of the etiological agent was only made after death, the clinical signs and analytic data were very suggestive of RHD.Most of the field and laboratory work referred to in this manuscript was supported by the FCT—Fundação para a Ciência e Tecnologia IP, Grant SFRH/BD/137067/2018, Grant UIDB/00276/2020. (and Project Fight-two: PTDC/CVT-CVT/29062/2017-PT2020), by Fundo Florestal Permanente (Government of Portugal) in the scope of the Action Plan for the Control of Rabbit Viral Haemorrhagic Disease (+COELHO, Dispatch no. 4757/2017 of 31 May, ref no. 2017014300001) and by Interdisciplinary Research Centre on Animal Health, Faculty of Veterinary Medicine, University of Lisbon (CIISA, FMV-UL) (Portugal). Funding bodies played no direct role in the design or conclusion of the study.MDPIRepositório da Universidade de LisboaAbade dos Santos, Fábio A.Magro, CarolinaCarvalho, Carina L.Ruivo, PedroDuarte, Margarida D.Peleteiro, Maria C.2021-02-10T13:00:13Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46271engAnimals (Basel). 2020 Dec 28;11(1):4010.3390/ani110100402076-2615info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T14:28:15Zoai:repositorio.ulisboa.pt:10451/46271Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:12:50.129960Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| title |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| spellingShingle |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit Abade dos Santos, Fábio A. European rabbit Oryctolagus cuniculus Pet rabbit Rabbit haemorrhagic disease Atypical clinical course Subacute |
| title_short |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| title_full |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| title_fullStr |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| title_full_unstemmed |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| title_sort |
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit |
| author |
Abade dos Santos, Fábio A. |
| author_facet |
Abade dos Santos, Fábio A. Magro, Carolina Carvalho, Carina L. Ruivo, Pedro Duarte, Margarida D. Peleteiro, Maria C. |
| author_role |
author |
| author2 |
Magro, Carolina Carvalho, Carina L. Ruivo, Pedro Duarte, Margarida D. Peleteiro, Maria C. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Abade dos Santos, Fábio A. Magro, Carolina Carvalho, Carina L. Ruivo, Pedro Duarte, Margarida D. Peleteiro, Maria C. |
| dc.subject.por.fl_str_mv |
European rabbit Oryctolagus cuniculus Pet rabbit Rabbit haemorrhagic disease Atypical clinical course Subacute |
| topic |
European rabbit Oryctolagus cuniculus Pet rabbit Rabbit haemorrhagic disease Atypical clinical course Subacute |
| description |
Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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2020 |
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2020 2020-01-01T00:00:00Z 2021-02-10T13:00:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10451/46271 |
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http://hdl.handle.net/10451/46271 |
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eng |
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eng |
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Animals (Basel). 2020 Dec 28;11(1):40 10.3390/ani11010040 2076-2615 |
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info:eu-repo/semantics/openAccess |
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MDPI |
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MDPI |
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