Cellular reprogramming as a tool to model human aging in a dish

Bibliographic Details
Main Author: Pitrez, Patrícia R.
Publication Date: 2024
Other Authors: Monteiro, Luís M., Borgogno, Oliver, Nissan, Xavier, Mertens, Jerome, Ferreira, Lino
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/10316/116126
https://doi.org/10.1038/s41467-024-46004-5
Summary: The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
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spelling Cellular reprogramming as a tool to model human aging in a dishHumansAgedAgingCellular ReprogrammingLongevityInduced Pluripotent Stem CellsThe design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.Nature Research2024-02-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://hdl.handle.net/10316/116126https://hdl.handle.net/10316/116126https://doi.org/10.1038/s41467-024-46004-5eng2041-1723https://www.nature.com/articles/s41467-024-46004-5Pitrez, Patrícia R.Monteiro, Luís M.Borgogno, OliverNissan, XavierMertens, JeromeFerreira, Linoinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-08-19T14:19:04Zoai:estudogeral.uc.pt:10316/116126Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:09:34.674569Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cellular reprogramming as a tool to model human aging in a dish
title Cellular reprogramming as a tool to model human aging in a dish
spellingShingle Cellular reprogramming as a tool to model human aging in a dish
Pitrez, Patrícia R.
Humans
Aged
Aging
Cellular Reprogramming
Longevity
Induced Pluripotent Stem Cells
title_short Cellular reprogramming as a tool to model human aging in a dish
title_full Cellular reprogramming as a tool to model human aging in a dish
title_fullStr Cellular reprogramming as a tool to model human aging in a dish
title_full_unstemmed Cellular reprogramming as a tool to model human aging in a dish
title_sort Cellular reprogramming as a tool to model human aging in a dish
author Pitrez, Patrícia R.
author_facet Pitrez, Patrícia R.
Monteiro, Luís M.
Borgogno, Oliver
Nissan, Xavier
Mertens, Jerome
Ferreira, Lino
author_role author
author2 Monteiro, Luís M.
Borgogno, Oliver
Nissan, Xavier
Mertens, Jerome
Ferreira, Lino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pitrez, Patrícia R.
Monteiro, Luís M.
Borgogno, Oliver
Nissan, Xavier
Mertens, Jerome
Ferreira, Lino
dc.subject.por.fl_str_mv Humans
Aged
Aging
Cellular Reprogramming
Longevity
Induced Pluripotent Stem Cells
topic Humans
Aged
Aging
Cellular Reprogramming
Longevity
Induced Pluripotent Stem Cells
description The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-28
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10316/116126
https://hdl.handle.net/10316/116126
https://doi.org/10.1038/s41467-024-46004-5
url https://hdl.handle.net/10316/116126
https://doi.org/10.1038/s41467-024-46004-5
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2041-1723
https://www.nature.com/articles/s41467-024-46004-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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