Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study
| Autor(a) principal: | |
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| Data de Publicação: | 2025 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/182630 |
Resumo: | Publisher Copyright: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
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Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) studyA cross-sectional analysisbreathlessnessDyspnoeaquality of lifePulmonary and Respiratory MedicinePublisher Copyright: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Introduction: Evidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of both physical and mental quality of life with breathlessness across several low-, middle- and high-income countries. Methods: We analysed data from 19 714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire, and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis. Results: Both physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = −7.59; 95%CI −8.60, −6.58; I2 = 78.5%) than for the mental component (coefficient = −3.50; 95%CI −4.36, −2.63; I2 = 71.4%). The association between physical component and breathlessness was stronger in high-income countries (coefficient = −8.82; 95%CI −10.15, −7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking. Conclusion: Quality of life is worse in people with breathlessness, but this association varies widely across the world.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNMüller, AlexanderWouters, Emiel F.M.Burney, PeterPotts, JamesCardoso, JoaoAl Ghobain, MohammedStudnicka, MichaelObaseki, DanielElsony, AsmaMortimer, KevinMannino, DavidJõgi, RainAhmed, RanaNafees, AsaadRodrigues, Maria FatimaBárbara, CristinaNielsen, RuneGíslason, ThorarinnCherkaski, Hamid HaceneEl Rhazi, KarimaJanson, ChristerAnand, Mahesh PadukudruJuvekar, SanjayDias, Herminia BritesFranssen, Frits M.E.Agarwal, DhirajHartl, SylviaSeemungal, TerenceParaguas, Stefanni NonnaHarrabi, ImedDenguezli, MeriamRashid, AbdulErhabor, GregoryBiaze, Mohammed ElKoul, ParvaizJanssen, Daisy J.A.Amaral, André F.S.2025-04-26T21:26:29Z2025-042025-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/182630eng2531-0429PURE: 115354713https://doi.org/10.1080/25310429.2025.2470566info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-19T01:39:19Zoai:run.unl.pt:10362/182630Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T06:33:32.692290Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study A cross-sectional analysis |
| title |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| spellingShingle |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study Müller, Alexander breathlessness Dyspnoea quality of life Pulmonary and Respiratory Medicine |
| title_short |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| title_full |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| title_fullStr |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| title_full_unstemmed |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| title_sort |
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study |
| author |
Müller, Alexander |
| author_facet |
Müller, Alexander Wouters, Emiel F.M. Burney, Peter Potts, James Cardoso, Joao Al Ghobain, Mohammed Studnicka, Michael Obaseki, Daniel Elsony, Asma Mortimer, Kevin Mannino, David Jõgi, Rain Ahmed, Rana Nafees, Asaad Rodrigues, Maria Fatima Bárbara, Cristina Nielsen, Rune Gíslason, Thorarinn Cherkaski, Hamid Hacene El Rhazi, Karima Janson, Christer Anand, Mahesh Padukudru Juvekar, Sanjay Dias, Herminia Brites Franssen, Frits M.E. Agarwal, Dhiraj Hartl, Sylvia Seemungal, Terence Paraguas, Stefanni Nonna Harrabi, Imed Denguezli, Meriam Rashid, Abdul Erhabor, Gregory Biaze, Mohammed El Koul, Parvaiz Janssen, Daisy J.A. Amaral, André F.S. |
| author_role |
author |
| author2 |
Wouters, Emiel F.M. Burney, Peter Potts, James Cardoso, Joao Al Ghobain, Mohammed Studnicka, Michael Obaseki, Daniel Elsony, Asma Mortimer, Kevin Mannino, David Jõgi, Rain Ahmed, Rana Nafees, Asaad Rodrigues, Maria Fatima Bárbara, Cristina Nielsen, Rune Gíslason, Thorarinn Cherkaski, Hamid Hacene El Rhazi, Karima Janson, Christer Anand, Mahesh Padukudru Juvekar, Sanjay Dias, Herminia Brites Franssen, Frits M.E. Agarwal, Dhiraj Hartl, Sylvia Seemungal, Terence Paraguas, Stefanni Nonna Harrabi, Imed Denguezli, Meriam Rashid, Abdul Erhabor, Gregory Biaze, Mohammed El Koul, Parvaiz Janssen, Daisy J.A. Amaral, André F.S. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Müller, Alexander Wouters, Emiel F.M. Burney, Peter Potts, James Cardoso, Joao Al Ghobain, Mohammed Studnicka, Michael Obaseki, Daniel Elsony, Asma Mortimer, Kevin Mannino, David Jõgi, Rain Ahmed, Rana Nafees, Asaad Rodrigues, Maria Fatima Bárbara, Cristina Nielsen, Rune Gíslason, Thorarinn Cherkaski, Hamid Hacene El Rhazi, Karima Janson, Christer Anand, Mahesh Padukudru Juvekar, Sanjay Dias, Herminia Brites Franssen, Frits M.E. Agarwal, Dhiraj Hartl, Sylvia Seemungal, Terence Paraguas, Stefanni Nonna Harrabi, Imed Denguezli, Meriam Rashid, Abdul Erhabor, Gregory Biaze, Mohammed El Koul, Parvaiz Janssen, Daisy J.A. Amaral, André F.S. |
| dc.subject.por.fl_str_mv |
breathlessness Dyspnoea quality of life Pulmonary and Respiratory Medicine |
| topic |
breathlessness Dyspnoea quality of life Pulmonary and Respiratory Medicine |
| description |
Publisher Copyright: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025-04-26T21:26:29Z 2025-04 2025-04-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/182630 |
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http://hdl.handle.net/10362/182630 |
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eng |
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eng |
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2531-0429 PURE: 115354713 https://doi.org/10.1080/25310429.2025.2470566 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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