Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus

• Autor(a) principal: Ingen-Housz-Oro, S.
• Data de Publicação: 2023
• Outros Autores: Schmidt, V., Ameri, M. M., Abe, R., Brassard, A., Mostaghimi, A., Paller, A. S., Romano, A., Didona, B., Kaffenberger, B. H., Ben Said, B., Thong, B. Y. H., Ramsay, B., Brezinova, E., Milpied, B., Mortz, C. G., Chu, C. Y., Sotozono, C., Gueudry, J., Fortune, D. G., Dridi, S. M., Tartar, D., Do-Pham, G., Gabison, E., Phillips, E. J., Lewis, F., Salavastru, C., Horvath, B., Dart, J., Setterfield, J., Newman, J., Schulz, J. T., Delcampe, A., Brockow, K., Seminario-Vidal, L., Jörg, L., Watson, M. P., Gonçalo, M., Lucas, M. C. Marco de, Torres, M., Noe, M. H., Hama, N., Shear, N. H., O'Reilly, P., Wolkenstein, P., Romanelli, P., Dodiuk-Gad, R. P., Micheletti, R. G., Tiplica, G. S., Sheridan, R., Rauz, S., Ahmad, S., Chua, S. L., Flynn, T. H., Pichler, W., Le, S. T., Maverakis, E., Walsh, N., French, L. E., Brüggen, M. C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Texto Completo: https://hdl.handle.net/10316/111619; https://doi.org/10.1186/s13023-023-02631-7
• topic: Epidermal necrolysis; Stevens-Johnson syndrome; Toxic epidermal necrolysis; Sequelae; Quality of life; Delphi; Consensus; Humans; Consensus; Skin; Disease Progression; Stevens-Johnson Syndrome

Background Long-term sequelae are frequent and often disabling after epidermal necrolysis (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)). However, consensus on the modalities of management of these sequelae is lacking. Objectives We conducted an international multicentric DELPHI exercise to establish a multidisciplinary expert consensus to standardize recommendations regarding management of SJS/TEN sequelae. Methods Participants were sent a survey via the online tool “Survey Monkey” consisting of 54 statements organized into 8 topics: general recommendations, professionals involved, skin, oral mucosa and teeth, eyes, genital area, mental health, and allergy workup. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). Results were analyzed according to the RAND/UCLA Appropriateness Method. Results Fifty-two healthcare professionals participated. After the first round, a consensus was obtained for 100% of 54 initially proposed statements (disagreement index < 1). Among them, 50 statements were agreed upon as ‘appropriate’; four statements were considered ‘uncertain’, and ultimately finally discarded. Conclusions Our DELPHI-based expert consensus should help guide physicians in conducting a prolonged multidisciplinary follow-up of sequelae in SJS-TEN.