Recent advances and perspectives of MicroNeedles for biomedical applications
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2025 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | https://hdl.handle.net/1822/95584 |
Resumo: | Published online: 24 April 2025 |
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Recent advances and perspectives of MicroNeedles for biomedical applicationsMicroNeedlesDrug deliveryMicrofabricationMicrofluidic devicesFluid extractionEngenharia e Tecnologia::Engenharia MédicaSaúde de qualidadePublished online: 24 April 2025Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of the diverse perspectives and applications of MNs, shedding light on their pivotal role in shaping the future of biomedical research and clinical practice. It begins by elucidating the fundamental principles of MNs: design, fabrication techniques, and materials, highlighting their capacity for minimally invasive access to the skin and underlying tissues. These attributes have driven advancements in transdermal drug delivery, facilitating precise and controlled administration of therapeutics, vaccines, and biologics, thus improving patient compliance and treatment outcomes. Furthermore, this review investigates the growing range of applications for MNs, including biomarker extraction, interstitial fluid (ISF) analysis, and continuous glucose monitoring. MNs enable real-time and minimally invasive monitoring of biochemical markers and have the potential to revolutionize disease diagnostics, personalized medicine, and wellness monitoring. Their compatibility with microfluidic systems further enhances their potential for point-of-care testing. This review serves as a comprehensive guide, highlighting the breadth of opportunities and challenges in leveraging MNs to improve healthcare outcomes and emphasizing the need for continued research and development in this dynamic field.Open access funding provided by FCT|FCCN (b-on). Fundação para a Ciência e a Tecnologia, 2022.06207.PTDC, PTDC/ EEI-EEE/2846/2021Springer NatureUniversidade do MinhoMaia, Renata FariaMachado, PedroRodrigues, Raquel OliveiraFaustino, Vera Luísa CarreiraSchütte, HelmutGassmann, StefanLima, Rui A.Minas, Graça20252025-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/95584engMaia, R.F., Machado, P., Rodrigues, R.O. et al. Recent advances and perspectives of MicroNeedles for biomedical applications. Biophys Rev (2025). https://doi.org/10.1007/s12551-025-01317-7 https://link.springer.com/article/10.1007/s12551-025-01317-71867-246910.1007/s12551-025-01317-7https://link.springer.com/article/10.1007/s12551-025-01317-7info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-17T01:18:07Zoai:repositorium.sdum.uminho.pt:1822/95584Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:29:11.645575Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| title |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| spellingShingle |
Recent advances and perspectives of MicroNeedles for biomedical applications Maia, Renata Faria MicroNeedles Drug delivery Microfabrication Microfluidic devices Fluid extraction Engenharia e Tecnologia::Engenharia Médica Saúde de qualidade |
| title_short |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| title_full |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| title_fullStr |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| title_full_unstemmed |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| title_sort |
Recent advances and perspectives of MicroNeedles for biomedical applications |
| author |
Maia, Renata Faria |
| author_facet |
Maia, Renata Faria Machado, Pedro Rodrigues, Raquel Oliveira Faustino, Vera Luísa Carreira Schütte, Helmut Gassmann, Stefan Lima, Rui A. Minas, Graça |
| author_role |
author |
| author2 |
Machado, Pedro Rodrigues, Raquel Oliveira Faustino, Vera Luísa Carreira Schütte, Helmut Gassmann, Stefan Lima, Rui A. Minas, Graça |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Maia, Renata Faria Machado, Pedro Rodrigues, Raquel Oliveira Faustino, Vera Luísa Carreira Schütte, Helmut Gassmann, Stefan Lima, Rui A. Minas, Graça |
| dc.subject.por.fl_str_mv |
MicroNeedles Drug delivery Microfabrication Microfluidic devices Fluid extraction Engenharia e Tecnologia::Engenharia Médica Saúde de qualidade |
| topic |
MicroNeedles Drug delivery Microfabrication Microfluidic devices Fluid extraction Engenharia e Tecnologia::Engenharia Médica Saúde de qualidade |
| description |
Published online: 24 April 2025 |
| publishDate |
2025 |
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2025 2025-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://hdl.handle.net/1822/95584 |
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https://hdl.handle.net/1822/95584 |
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eng |
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eng |
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Maia, R.F., Machado, P., Rodrigues, R.O. et al. Recent advances and perspectives of MicroNeedles for biomedical applications. Biophys Rev (2025). https://doi.org/10.1007/s12551-025-01317-7 https://link.springer.com/article/10.1007/s12551-025-01317-7 1867-2469 10.1007/s12551-025-01317-7 https://link.springer.com/article/10.1007/s12551-025-01317-7 |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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