Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma

Bibliographic Details
Main Author: Nascimento, Catarina
Publication Date: 2021
Other Authors: Gameiro, Andreia, Ferreira, Fernando, Correia, Jorge Manuel de Jesus, Ferreira, João
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.5/23477
Summary: Research Areas: Oncology
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spelling Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinomaFeline mammary carcinomaVEGF-AVEGFR-1VEGFR-2Non-invasive biomarkersAngiogenesisResearch Areas: OncologyVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these molecules in tumor-infiltrating lymphocytes (TILs) and in cancer cells was evaluated and compared with its serum levels. Results obtained showed that serum VEGF-A levels were significantly higher in cats with HER2-positive and Triple Negative (TN) Normal-Like subtypes, when compared to control group (p = 0.001, p = 0.020). Additionally, serum VEGFR-1 levels were significantly elevated in cats presenting luminal A, HER2-positive and TN Normal-Like tumors (p = 0.011, p = 0.048, p = 0.006), as serum VEGFR-2 levels (p = 0.010, p = 0.046, p = 0.005). Moreover, a positive interaction was found between the expression of VEGF-A, VEGFR-1, and VEGFR-2 in TILs and their serum levels (p = 0.002, p = 0.003, p = 0.003). In summary, these findings point to the usefulness of VEGF-A and its serum receptors assessment in clinical evaluation of cats with HER2-positive and TN Normal-Like tumors, suggesting that targeted therapies against these molecules may be effective for the treatment of these animals, as described in human breast cancer.MDPIRepositório da Universidade de LisboaNascimento, CatarinaGameiro, AndreiaFerreira, FernandoCorreia, Jorge Manuel de JesusFerreira, João2022-02-13T22:57:13Z2021-01-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/23477engNascimento C, Gameiro A, Ferreira J, Correia J, Ferreira F. 2021. Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma. Cancers, 13(1):117. Doi: 10.3390/cancers1301011710.3390/cancers130101172072-6694info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T15:23:53Zoai:repositorio.ulisboa.pt:10400.5/23477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T03:42:18.986639Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
title Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
spellingShingle Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
Nascimento, Catarina
Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
title_short Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
title_full Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
title_fullStr Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
title_full_unstemmed Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
title_sort Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
author Nascimento, Catarina
author_facet Nascimento, Catarina
Gameiro, Andreia
Ferreira, Fernando
Correia, Jorge Manuel de Jesus
Ferreira, João
author_role author
author2 Gameiro, Andreia
Ferreira, Fernando
Correia, Jorge Manuel de Jesus
Ferreira, João
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Nascimento, Catarina
Gameiro, Andreia
Ferreira, Fernando
Correia, Jorge Manuel de Jesus
Ferreira, João
dc.subject.por.fl_str_mv Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
topic Feline mammary carcinoma
VEGF-A
VEGFR-1
VEGFR-2
Non-invasive biomarkers
Angiogenesis
description Research Areas: Oncology
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2021-01-01T00:00:00Z
2022-02-13T22:57:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/23477
url http://hdl.handle.net/10400.5/23477
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nascimento C, Gameiro A, Ferreira J, Correia J, Ferreira F. 2021. Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma. Cancers, 13(1):117. Doi: 10.3390/cancers13010117
10.3390/cancers13010117
2072-6694
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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