Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder

Detalhes bibliográficos
Autor(a) principal: Neto, Susana
Data de Publicação: 2015
Outros Autores: Quintela Vieira, Ana Filipa, Montezuma, Diana, Costa, Natália R., Antunes, Luís, Baptista, Tiago, Oliveira, Ana Isabel, Pinho dos Santos Graça, Maria Inês, Rodrigues, Ângelo, Magalhães, José S., Oliveira, Jorge, Henrique, Rui, Jerónimo, Carmen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.22/12800
Resumo: Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
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spelling Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladderUrinary BladderAgedRNABladder NeoplasmsBladder NeoplasmsDeregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.REPOSITÓRIO P.PORTONeto, SusanaQuintela Vieira, Ana FilipaMontezuma, DianaCosta, Natália R.Antunes, LuísBaptista, TiagoOliveira, Ana IsabelPinho dos Santos Graça, Maria InêsRodrigues, ÂngeloMagalhães, José S.Oliveira, JorgeHenrique, RuiJerónimo, Carmen2019-01-30T18:06:23Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/12800eng10.1002/mc.22117info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-07T10:28:59Zoai:recipp.ipp.pt:10400.22/12800Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:56:54.324699Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
title Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
spellingShingle Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
Neto, Susana
Urinary Bladder
Aged
RNA
Bladder Neoplasms
Bladder Neoplasms
title_short Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
title_full Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
title_fullStr Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
title_full_unstemmed Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
title_sort Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
author Neto, Susana
author_facet Neto, Susana
Quintela Vieira, Ana Filipa
Montezuma, Diana
Costa, Natália R.
Antunes, Luís
Baptista, Tiago
Oliveira, Ana Isabel
Pinho dos Santos Graça, Maria Inês
Rodrigues, Ângelo
Magalhães, José S.
Oliveira, Jorge
Henrique, Rui
Jerónimo, Carmen
author_role author
author2 Quintela Vieira, Ana Filipa
Montezuma, Diana
Costa, Natália R.
Antunes, Luís
Baptista, Tiago
Oliveira, Ana Isabel
Pinho dos Santos Graça, Maria Inês
Rodrigues, Ângelo
Magalhães, José S.
Oliveira, Jorge
Henrique, Rui
Jerónimo, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv REPOSITÓRIO P.PORTO
dc.contributor.author.fl_str_mv Neto, Susana
Quintela Vieira, Ana Filipa
Montezuma, Diana
Costa, Natália R.
Antunes, Luís
Baptista, Tiago
Oliveira, Ana Isabel
Pinho dos Santos Graça, Maria Inês
Rodrigues, Ângelo
Magalhães, José S.
Oliveira, Jorge
Henrique, Rui
Jerónimo, Carmen
dc.subject.por.fl_str_mv Urinary Bladder
Aged
RNA
Bladder Neoplasms
Bladder Neoplasms
topic Urinary Bladder
Aged
RNA
Bladder Neoplasms
Bladder Neoplasms
description Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2019-01-30T18:06:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/12800
url http://hdl.handle.net/10400.22/12800
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1002/mc.22117
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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