Cartilage repair using hydrogels: a critical review of in vivo experimental designs

Detalhes bibliográficos
Autor(a) principal: Vilela, Carlos
Data de Publicação: 2015
Outros Autores: Correia, C., Oliveira, J. M., Sousa, R. A., Mendes, João Espregueira, Reis, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/1822/38397
Resumo: Prova tipográfica
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spelling Cartilage repair using hydrogels: a critical review of in vivo experimental designsCartilage repairIn vivo modelsTissue engineeringHydrogelsGelsAnimalin vivoCiências Médicas::Biotecnologia MédicaScience & TechnologyProva tipográfica This review analyzes the outcomes and technical aspects of in vivo studies published in the past decade using gels and hydrogels for cartilage repair. Using PubMed search engine, original research publications during the period of 2002/01/01 to 2015/04/30 identifi ed 115 published papers. Of these, 3 studies failed to fi nd a statistically significant improvement of treatment group as compared to control and 18 studies did not clearly identify hyaline-like cartilage formation in the treated groups. The most frequent repaired lesion was the rabbit acute full thickness trochlear defect, using a scaff old combining a gel or hydrogel and other material. One third of the scaff olds were cell-free (35%) and the majority of the studies did not use growth factors (71%). The present review may constitute a useful tool in design of future studies, as limitations of study designs are pointed and results in terms of translation to human application is discussed.ARTICULATE project 623 (QREN-13/SI/2011-23189)American Chemical SocietyUniversidade do MinhoVilela, CarlosCorreia, C.Oliveira, J. M.Sousa, R. A.Mendes, João EspregueiraReis, R. L.2015-082015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/38397engVilela C. A., Correia C., Oliveira J. M., Sousa R. A., Espregueira-Mendes J., Reis R. L. Cartilage Repair Using Hydrogels: A Critical Review of in Vivo Experimental Designs, ACS Biomater. Sci. Eng., Vol. 1, Issue 9, pp. 726–739, doi:10.1021/acsbiomaterials.5b00245, 20152373-987810.1021/acsbiomaterials.5b00245http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00245info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:58:40Zoai:repositorium.sdum.uminho.pt:1822/38397Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:10:58.156248Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Cartilage repair using hydrogels: a critical review of in vivo experimental designs
title Cartilage repair using hydrogels: a critical review of in vivo experimental designs
spellingShingle Cartilage repair using hydrogels: a critical review of in vivo experimental designs
Vilela, Carlos
Cartilage repair
In vivo models
Tissue engineering
Hydrogels
Gels
Animal
in vivo
Ciências Médicas::Biotecnologia Médica
Science & Technology
title_short Cartilage repair using hydrogels: a critical review of in vivo experimental designs
title_full Cartilage repair using hydrogels: a critical review of in vivo experimental designs
title_fullStr Cartilage repair using hydrogels: a critical review of in vivo experimental designs
title_full_unstemmed Cartilage repair using hydrogels: a critical review of in vivo experimental designs
title_sort Cartilage repair using hydrogels: a critical review of in vivo experimental designs
author Vilela, Carlos
author_facet Vilela, Carlos
Correia, C.
Oliveira, J. M.
Sousa, R. A.
Mendes, João Espregueira
Reis, R. L.
author_role author
author2 Correia, C.
Oliveira, J. M.
Sousa, R. A.
Mendes, João Espregueira
Reis, R. L.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Vilela, Carlos
Correia, C.
Oliveira, J. M.
Sousa, R. A.
Mendes, João Espregueira
Reis, R. L.
dc.subject.por.fl_str_mv Cartilage repair
In vivo models
Tissue engineering
Hydrogels
Gels
Animal
in vivo
Ciências Médicas::Biotecnologia Médica
Science & Technology
topic Cartilage repair
In vivo models
Tissue engineering
Hydrogels
Gels
Animal
in vivo
Ciências Médicas::Biotecnologia Médica
Science & Technology
description Prova tipográfica
publishDate 2015
dc.date.none.fl_str_mv 2015-08
2015-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/38397
url http://hdl.handle.net/1822/38397
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vilela C. A., Correia C., Oliveira J. M., Sousa R. A., Espregueira-Mendes J., Reis R. L. Cartilage Repair Using Hydrogels: A Critical Review of in Vivo Experimental Designs, ACS Biomater. Sci. Eng., Vol. 1, Issue 9, pp. 726–739, doi:10.1021/acsbiomaterials.5b00245, 2015
2373-9878
10.1021/acsbiomaterials.5b00245
http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00245
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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