Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10451/28769 |
Resumo: | © 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy© 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïve CD4 T-cell depletion and contraction of T-cell receptor diversity. Notwithstanding this, there was neither increased incidence of autoimmune disease in comparison with age-matched controls nor significant changes in their IgG/IgA/IgM/IgE autoreactivity profiles, as assessed through extensive arrays. We reasoned that the observed relative preservation of the regulatory T-cell compartment, including maintenance of naïve regulatory CD4 T-cells, may contribute to limit the emergence of autoimmunity upon thymectomy. Our findings have implications in other clinical settings with impaired thymic activity, and are particularly relevant to studies of autoimmunity in ageing.This work was supported by Fundação para a Ciência e Tecnologia (FCT; POCI2010/IC/83068/2007 to RMMV; PTDC/SAU-MIC/109786/2009 to AES), and Gulbenkian Foundation (P132532/2013 to AES). SLS, ASA and AJA received FCT scholarships. AJA was supported by an EMBO long-term fellowship (ALT-33-2010) and a Marie Curie European Integration Grant (PERGGA-2009-256595).Public Library of ScienceRepositório da Universidade de LisboaSilva, Susana L.Albuquerque, AdrianaAmaral, Andreia J.Li, Quan-ZhenMota, CatarinaCheynier, RémiVictorino, Rui M. M.Santos, M. Conceição PereiraSousa, Ana E.2017-08-24T13:25:43Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/28769engPLOS ONE | July 7, 20171932-620310.1371/journal.pone.0180385info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:42:44Zoai:repositorio.ulisboa.pt:10451/28769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:51:59.228404Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| title |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| spellingShingle |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy Silva, Susana L. |
| title_short |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| title_full |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| title_fullStr |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| title_full_unstemmed |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| title_sort |
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy |
| author |
Silva, Susana L. |
| author_facet |
Silva, Susana L. Albuquerque, Adriana Amaral, Andreia J. Li, Quan-Zhen Mota, Catarina Cheynier, Rémi Victorino, Rui M. M. Santos, M. Conceição Pereira Sousa, Ana E. |
| author_role |
author |
| author2 |
Albuquerque, Adriana Amaral, Andreia J. Li, Quan-Zhen Mota, Catarina Cheynier, Rémi Victorino, Rui M. M. Santos, M. Conceição Pereira Sousa, Ana E. |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Silva, Susana L. Albuquerque, Adriana Amaral, Andreia J. Li, Quan-Zhen Mota, Catarina Cheynier, Rémi Victorino, Rui M. M. Santos, M. Conceição Pereira Sousa, Ana E. |
| description |
© 2017 Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-08-24T13:25:43Z 2017 2017-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/28769 |
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http://hdl.handle.net/10451/28769 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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PLOS ONE | July 7, 2017 1932-6203 10.1371/journal.pone.0180385 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Public Library of Science |
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Public Library of Science |
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