Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM)
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| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/165562 |
Summary: | Publisher Copyright: © 2024 The Author(s) |
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Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM)Epidemiology and antimicrobial resistance burden from a cohort of 27 hospitals, 2020–2022AmpC β-lactamaseAntimicrobial resistanceBlood cultureCOVID-19EnterobacteralesSepsisMicrobiology (medical)Infectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingPublisher Copyright: © 2024 The Author(s)Introduction: The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia species and Morganella morganii) has not yet been incorporated into systematic surveillance programs. Methods: We conducted a multicentre retrospective observational study analysing all ESCPM strains isolated from blood cultures in 27 European hospitals over a 3-year period (2020–2022). Diagnostic approach, epidemiology, and antimicrobial susceptibility were investigated. Results: Our study comprised 6,774 ESCPM isolates. MALDI-TOF coupled to mass spectrometry was the predominant technique for bacterial identification. Susceptibility to new β-lactam/β-lactamase inhibitor combinations and confirmation of AmpC overproduction were routinely tested in 33.3% and 29.6% of the centres, respectively. The most prevalent species were E. cloacae complex (44.8%) and S. marcescens (22.7%). Overall, third-generation cephalosporins (3GC), combined third- and fourth-generation cephalosporins (3GC + 4GC) and carbapenems resistance phenotypes were observed in 15.7%, 4.6%, and 9.5% of the isolates, respectively. AmpC overproduction was the most prevalent resistance mechanism detected (15.8%). Among carbapenemase-producers, carbapenemase type was provided in 44.4% of the isolates, VIM- (22.9%) and OXA-48-enzyme (16%) being the most frequently detected. E. cloacae complex, K. aerogenes and Providencia species exhibited the most notable cumulative antimicrobial resistance profiles, with the former displaying 3GC, combined 3GC + 4GC and carbapenems resistance phenotypes in 15.2%, 7.4%, and 12.8% of the isolates, respectively. K. aerogenes showed the highest rate of both 3GC resistant phenotype (29.8%) and AmpC overproduction (32.1%), while Providencia species those of both carbapenems resistance phenotype (42.7%) and carbapenemase production (29.4%). ESCPM isolates exhibiting both 3GC and combined 3GC + 4GC resistance phenotypes displayed high susceptibility to ceftazidime/avibactam (98.2% and 95.7%, respectively) and colistin (90.3% and 90.7%, respectively). Colistin emerged as the most active drug against ESCPM species (except those intrinsically resistant) displaying both carbapenems resistance phenotype (85.8%) and carbapenemase production (97.8%). Conclusions: This study presented a current analysis of ESCPM species epidemiology in Europe, providing insights to inform current antibiotic treatments and guide strategies for antimicrobial stewardship and diagnostics.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBoattini, MatteoBianco, GabrieleLlorente, Laura IglesiasAcero, Laura AlonsoNunes, DanielSeruca, MiguelMendes, Vasco SantosAlmeida, AndréBastos, PauloRodríguez-Villodres, ÁngelGascón, Adelina GimenoHalperin, Ana VerónicaCantón, RafaelEscartín, Maria Nieves LarrosaGonzález-López, Juan JoséFloch, PaulineMassip, ClémenceChainier, DelphineBarraud, OlivierDortet, LaurentCuzon, GaëlleZancanaro, ClémentMizrahi, AssafSchade, RogierRasmussen, Asger NellemannSchønning, KristianHamprecht, AxelSchaffarczyk, LukasGlöckner, StefanRödel, JürgenKristóf, KatalinBalonyi, ÁgnesMancini, StefanoQuiblier, ChantalFasciana, TeresaGiammanco, AnnaPaglietti, BiancaRubino, SalvatoreBudimir, AnaBedenić, BrankaRubic, ZanaMarinović, JelenaGartzonika, KonstantinaChristaki, EiriniMavromanolaki, Viktoria EiriniMaraki, SofiaYalçın, Tuğba YanıkAzap, Özlem KurtLicker, MonicaMusuroi, CorinaTalapan, DanielaVrancianu, Corneliu OvidiuComini, SaraZalas-Więcek, PatrycjaMichalska, AnnaCavallo, RossanaMelo Cristino, JoséCosta, Cristina2024-03-28T00:11:26Z2024-052024-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/165562eng0924-8579PURE: 86576654https://doi.org/10.1016/j.ijantimicag.2024.107115info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:20:02Zoai:run.unl.pt:10362/165562Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:50:48.004472Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) Epidemiology and antimicrobial resistance burden from a cohort of 27 hospitals, 2020–2022 |
| title |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| spellingShingle |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) Boattini, Matteo AmpC β-lactamase Antimicrobial resistance Blood culture COVID-19 Enterobacterales Sepsis Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| title_short |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| title_full |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| title_fullStr |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| title_full_unstemmed |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| title_sort |
Enterobacterales carrying chromosomal AmpC β-lactamases in Europe (EuESCPM) |
| author |
Boattini, Matteo |
| author_facet |
Boattini, Matteo Bianco, Gabriele Llorente, Laura Iglesias Acero, Laura Alonso Nunes, Daniel Seruca, Miguel Mendes, Vasco Santos Almeida, André Bastos, Paulo Rodríguez-Villodres, Ángel Gascón, Adelina Gimeno Halperin, Ana Verónica Cantón, Rafael Escartín, Maria Nieves Larrosa González-López, Juan José Floch, Pauline Massip, Clémence Chainier, Delphine Barraud, Olivier Dortet, Laurent Cuzon, Gaëlle Zancanaro, Clément Mizrahi, Assaf Schade, Rogier Rasmussen, Asger Nellemann Schønning, Kristian Hamprecht, Axel Schaffarczyk, Lukas Glöckner, Stefan Rödel, Jürgen Kristóf, Katalin Balonyi, Ágnes Mancini, Stefano Quiblier, Chantal Fasciana, Teresa Giammanco, Anna Paglietti, Bianca Rubino, Salvatore Budimir, Ana Bedenić, Branka Rubic, Zana Marinović, Jelena Gartzonika, Konstantina Christaki, Eirini Mavromanolaki, Viktoria Eirini Maraki, Sofia Yalçın, Tuğba Yanık Azap, Özlem Kurt Licker, Monica Musuroi, Corina Talapan, Daniela Vrancianu, Corneliu Ovidiu Comini, Sara Zalas-Więcek, Patrycja Michalska, Anna Cavallo, Rossana Melo Cristino, José Costa, Cristina |
| author_role |
author |
| author2 |
Bianco, Gabriele Llorente, Laura Iglesias Acero, Laura Alonso Nunes, Daniel Seruca, Miguel Mendes, Vasco Santos Almeida, André Bastos, Paulo Rodríguez-Villodres, Ángel Gascón, Adelina Gimeno Halperin, Ana Verónica Cantón, Rafael Escartín, Maria Nieves Larrosa González-López, Juan José Floch, Pauline Massip, Clémence Chainier, Delphine Barraud, Olivier Dortet, Laurent Cuzon, Gaëlle Zancanaro, Clément Mizrahi, Assaf Schade, Rogier Rasmussen, Asger Nellemann Schønning, Kristian Hamprecht, Axel Schaffarczyk, Lukas Glöckner, Stefan Rödel, Jürgen Kristóf, Katalin Balonyi, Ágnes Mancini, Stefano Quiblier, Chantal Fasciana, Teresa Giammanco, Anna Paglietti, Bianca Rubino, Salvatore Budimir, Ana Bedenić, Branka Rubic, Zana Marinović, Jelena Gartzonika, Konstantina Christaki, Eirini Mavromanolaki, Viktoria Eirini Maraki, Sofia Yalçın, Tuğba Yanık Azap, Özlem Kurt Licker, Monica Musuroi, Corina Talapan, Daniela Vrancianu, Corneliu Ovidiu Comini, Sara Zalas-Więcek, Patrycja Michalska, Anna Cavallo, Rossana Melo Cristino, José Costa, Cristina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Boattini, Matteo Bianco, Gabriele Llorente, Laura Iglesias Acero, Laura Alonso Nunes, Daniel Seruca, Miguel Mendes, Vasco Santos Almeida, André Bastos, Paulo Rodríguez-Villodres, Ángel Gascón, Adelina Gimeno Halperin, Ana Verónica Cantón, Rafael Escartín, Maria Nieves Larrosa González-López, Juan José Floch, Pauline Massip, Clémence Chainier, Delphine Barraud, Olivier Dortet, Laurent Cuzon, Gaëlle Zancanaro, Clément Mizrahi, Assaf Schade, Rogier Rasmussen, Asger Nellemann Schønning, Kristian Hamprecht, Axel Schaffarczyk, Lukas Glöckner, Stefan Rödel, Jürgen Kristóf, Katalin Balonyi, Ágnes Mancini, Stefano Quiblier, Chantal Fasciana, Teresa Giammanco, Anna Paglietti, Bianca Rubino, Salvatore Budimir, Ana Bedenić, Branka Rubic, Zana Marinović, Jelena Gartzonika, Konstantina Christaki, Eirini Mavromanolaki, Viktoria Eirini Maraki, Sofia Yalçın, Tuğba Yanık Azap, Özlem Kurt Licker, Monica Musuroi, Corina Talapan, Daniela Vrancianu, Corneliu Ovidiu Comini, Sara Zalas-Więcek, Patrycja Michalska, Anna Cavallo, Rossana Melo Cristino, José Costa, Cristina |
| dc.subject.por.fl_str_mv |
AmpC β-lactamase Antimicrobial resistance Blood culture COVID-19 Enterobacterales Sepsis Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| topic |
AmpC β-lactamase Antimicrobial resistance Blood culture COVID-19 Enterobacterales Sepsis Microbiology (medical) Infectious Diseases Pharmacology (medical) SDG 3 - Good Health and Well-being |
| description |
Publisher Copyright: © 2024 The Author(s) |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-03-28T00:11:26Z 2024-05 2024-05-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/165562 |
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eng |
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eng |
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0924-8579 PURE: 86576654 https://doi.org/10.1016/j.ijantimicag.2024.107115 |
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openAccess |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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