Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones

Bibliographic Details
Main Author: Rio, Irina S. R.
Publication Date: 2019
Other Authors: Rodrigues, Juliana M., Rodrigues, Ana Rita Oliveira, Coutinho, Paulo J. G., Castanheira, Elisabete M. S., Queiroz, Maria João R. P.
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/1822/60769
Summary: In this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy).
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spelling Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactonesMagnetic/plasmonic nanoparticlesMagnetoliposomesDrug deliveryAntitumor drugsCancer therapyEngenharia e Tecnologia::NanotecnologiaIn this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy).FCT-Portugal, FEDER, PORTUGAL2020 and COMPETE2020 for funding under Project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020) and Strategic funding of CF-UM-UP (UID/FIS/04650/2019) and CQUM (UID/QUI/00686/2019). J.M.R. PhD grant is financed by FCT, POCH and ESFRICT 2019. Organizing CommitteeUniversidade do MinhoRio, Irina S. R.Rodrigues, Juliana M.Rodrigues, Ana Rita OliveiraCoutinho, Paulo J. G.Castanheira, Elisabete M. S.Queiroz, Maria João R. P.20192019-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/60769enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T07:32:11Zoai:repositorium.sdum.uminho.pt:1822/60769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:30:34.424888Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
title Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
spellingShingle Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
Rio, Irina S. R.
Magnetic/plasmonic nanoparticles
Magnetoliposomes
Drug delivery
Antitumor drugs
Cancer therapy
Engenharia e Tecnologia::Nanotecnologia
title_short Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
title_full Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
title_fullStr Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
title_full_unstemmed Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
title_sort Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
author Rio, Irina S. R.
author_facet Rio, Irina S. R.
Rodrigues, Juliana M.
Rodrigues, Ana Rita Oliveira
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
Queiroz, Maria João R. P.
author_role author
author2 Rodrigues, Juliana M.
Rodrigues, Ana Rita Oliveira
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
Queiroz, Maria João R. P.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rio, Irina S. R.
Rodrigues, Juliana M.
Rodrigues, Ana Rita Oliveira
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
Queiroz, Maria João R. P.
dc.subject.por.fl_str_mv Magnetic/plasmonic nanoparticles
Magnetoliposomes
Drug delivery
Antitumor drugs
Cancer therapy
Engenharia e Tecnologia::Nanotecnologia
topic Magnetic/plasmonic nanoparticles
Magnetoliposomes
Drug delivery
Antitumor drugs
Cancer therapy
Engenharia e Tecnologia::Nanotecnologia
description In this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy).
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/60769
url http://hdl.handle.net/1822/60769
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv RICT 2019. Organizing Committee
publisher.none.fl_str_mv RICT 2019. Organizing Committee
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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