45Ti - Titanium: from cyclotron production to potential applications evaluation

• Main Author: Costa, Pedro
• Publication Date: 2015
• Other Authors: Metello, Luís F., Cunha, Lídia, Lass, Piotr, Currie, Geoff, Johnson, Richard R., Gelbart, W., Obermair, J., Artner, Christoph, Alves, Francisco, Naia, M. Duarte
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10400.22/6435

Introduction: Thousands of radioisotopes are known and virtually all may be artificially produced, however clinical applications of PET imaging are mainly based on 18F, 11C, 13N and 68Ga. This trend could change in the near future, since several groups worldwide are busy developing very promising new entities aiming to contribute for spreading the use and efficacy of clinical diagnostic using Nuclear Medicine imaging techniques. Our group is developing 45Ti-Titanium, assuming it as a potential candidate, since presenting interesting properties: physical half-life of 3.09h, together with relevant chemical properties, that enable radiolabelling with bifunctional chelates, ligands or could even be useful for studies concerning the distribution of new titanium-based chemotherapy drugs or titanium oxide nanoparticles. Considering that data characterizing excitation functions is necessary for radionuclide optimal production, this work aims to disseminate results regarding the determination of excitation function of 45Sc(p,n)45Ti reaction, studied as a potential route to produce 45Ti in low energy cyclotrons.