Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand

Bibliographic Details
Main Author: Pereira-da-Silva, Tiago
Publication Date: 2020
Other Authors: Napoleao, Patricia, Pinheiro, Teresa, Selas, Mafalda, Silva, Filipa, Ferreira, Rui Cruz, Carmo, Miguel Mota
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/113593
Summary: This study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis.
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spelling Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligandChronic coronary syndromecoronary artery diseaseinflammationsoluble CD40 ligandThis study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis.Introduction: Inflammation contributes to the initiation and progression of atherosclerosis, although the underlying inflammatory pathways are not entirely known. Specifically, the role of the proinflammatory soluble CD40 ligand (sCD40L) on the expression of chronic coronary syndrome (CCS) is not completely understood. We evaluated whether sCD40L expression is associated with the presence of CCS and with the clinical and anatomical severity of CCS. Methods: We prospectively recruited 94 participants, assigned to two groups matched by age and sex, without coronary artery disease (n=26) and with CCS (n=68). Clinical, laboratory and anatomical data were prospectively collected, and serum levels of sCD40L were measured. Results: In patients with CCS, classic cardiovascular risk factors were more prevalent, and the sCD40L levels, leukocyte and neutrophil counts, and neutrophil/lymphocyte ratio, but not the C-reactive protein levels, were significantly higher than those in controls. sCD40L was independently associated with the presence of obstructive coronary artery disease in multivariate analysis. Regarding CCS severity, sCD40L levels showed a significant stepwise increase with increasing angina severity (ANOVA P=0.001). In addition, sCD40L was independently associated with the anatomical severity of coronary artery disease, as assessed by the Gensini score. Among patients with CCS, those with previous coronary artery bypass grafting (n=23) had lower sCD40L levels than patients waiting for revascularization (n=45) [4.3 (2.1) ng/mL vs. 6.8 (3.5) ng/mL, P=0.001]. Conclusions: The expression of the proinflammatory sCD40L was associated with the presence of CCS and reflected the clinical and anatomical severity of CCS. In addition, we describe for the first time the association between prior CABG and reduced sCD40L levels in patients with CCS.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNPereira-da-Silva, TiagoNapoleao, PatriciaPinheiro, TeresaSelas, MafaldaSilva, FilipaFerreira, Rui CruzCarmo, Miguel Mota2021-03-09T23:57:20Z2020-10-152020-10-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/113593eng2160-200XPURE: 26667932info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:51:06Zoai:run.unl.pt:10362/113593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:22:21.897974Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
spellingShingle Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
Pereira-da-Silva, Tiago
Chronic coronary syndrome
coronary artery disease
inflammation
soluble CD40 ligand
title_short Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_full Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_fullStr Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_full_unstemmed Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
title_sort Inflammation is associated with the presence and severity of chronic coronary syndrome through soluble CD40 ligand
author Pereira-da-Silva, Tiago
author_facet Pereira-da-Silva, Tiago
Napoleao, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author_role author
author2 Napoleao, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Pereira-da-Silva, Tiago
Napoleao, Patricia
Pinheiro, Teresa
Selas, Mafalda
Silva, Filipa
Ferreira, Rui Cruz
Carmo, Miguel Mota
dc.subject.por.fl_str_mv Chronic coronary syndrome
coronary artery disease
inflammation
soluble CD40 ligand
topic Chronic coronary syndrome
coronary artery disease
inflammation
soluble CD40 ligand
description This study is part of the PhD thesis program of one of the authors (TPdS), supervised (MMC) and co-supervised (PN) by other two, conducted in NOVA Medical School/Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. TP acknowledges the support of Fundação para a Ciência e Tecnologia, Portugal (Project UID/BIO/04565/ 2020), and Programa Operacional Regional de Lisboa 2020 (Project N. 007317). The authors are grateful to Joana Castro, PhD, from Medinres - Medical Information and Research, for her advice in the statistical analysis.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-15
2020-10-15T00:00:00Z
2021-03-09T23:57:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/113593
url http://hdl.handle.net/10362/113593
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2160-200X
PURE: 26667932
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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