A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans

Bibliographic Details
Main Author: Timmins, Joanna
Publication Date: 2016
Other Authors: Moe, Elin
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://doi.org/10.1016/j.csbj.2016.04.001
Summary: The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.
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spelling A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radioduransMajor Findings, Functional and Mechanistic Insight and ChallengesBiotechnologyBiophysicsStructural BiologyBiochemistryGeneticsComputer Science ApplicationsThe Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Molecular, Structural and Cellular Microbiology (MOSTMICRO)RUNTimmins, JoannaMoe, Elin2019-10-24T22:35:11Z2016-01-012016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttps://doi.org/10.1016/j.csbj.2016.04.001eng2001-0370PURE: 4059990http://www.scopus.com/inward/record.url?scp=84969815928&partnerID=8YFLogxKhttps://doi.org/10.1016/j.csbj.2016.04.001info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:41:52Zoai:run.unl.pt:10362/85346Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:13:19.054747Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
Major Findings, Functional and Mechanistic Insight and Challenges
title A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
spellingShingle A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
Timmins, Joanna
Biotechnology
Biophysics
Structural Biology
Biochemistry
Genetics
Computer Science Applications
title_short A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
title_full A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
title_fullStr A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
title_full_unstemmed A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
title_sort A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
author Timmins, Joanna
author_facet Timmins, Joanna
Moe, Elin
author_role author
author2 Moe, Elin
author2_role author
dc.contributor.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
Molecular, Structural and Cellular Microbiology (MOSTMICRO)
RUN
dc.contributor.author.fl_str_mv Timmins, Joanna
Moe, Elin
dc.subject.por.fl_str_mv Biotechnology
Biophysics
Structural Biology
Biochemistry
Genetics
Computer Science Applications
topic Biotechnology
Biophysics
Structural Biology
Biochemistry
Genetics
Computer Science Applications
description The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
2016-01-01T00:00:00Z
2019-10-24T22:35:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1016/j.csbj.2016.04.001
url https://doi.org/10.1016/j.csbj.2016.04.001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2001-0370
PURE: 4059990
http://www.scopus.com/inward/record.url?scp=84969815928&partnerID=8YFLogxK
https://doi.org/10.1016/j.csbj.2016.04.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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