NORAD-regulated signaling pathways in breast cancer progression

Bibliographic Details
Main Author: Capela, Ana Maria
Publication Date: 2024
Other Authors: Tavares-Marcos, Carlota, Estima-Arede, Hugo F., Nóbrega-Pereira, Sandrina, Jesus, Bruno Bernardes de
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10773/43455
Summary: Long non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD's extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this pathology. Through the preferential binding to pumilio (PUM) proteins PUM1 and PUM2, NORAD has been shown to be involved in the control of cell cycle, angiogenesis, mitosis, DNA replication and transcription and protein translation. More recently, NORAD has been associated with PUM-independent roles, accomplished by interacting with other ncRNAs, mRNAs and proteins. The intricate network of NORAD-mediated signaling pathways may provide insights into the potential design of novel unexplored strategies to overcome chemotherapy resistance in BC treatment.
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spelling NORAD-regulated signaling pathways in breast cancer progressionLncRNAsNORADPumilioBreast cancerChemotherapy resistanceLong non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD's extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this pathology. Through the preferential binding to pumilio (PUM) proteins PUM1 and PUM2, NORAD has been shown to be involved in the control of cell cycle, angiogenesis, mitosis, DNA replication and transcription and protein translation. More recently, NORAD has been associated with PUM-independent roles, accomplished by interacting with other ncRNAs, mRNAs and proteins. The intricate network of NORAD-mediated signaling pathways may provide insights into the potential design of novel unexplored strategies to overcome chemotherapy resistance in BC treatment.MDPI2025-01-16T09:38:17Z2024-02-01T00:00:00Z2024-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/43455eng2072-669410.3390/cancers16030636Capela, Ana MariaTavares-Marcos, CarlotaEstima-Arede, Hugo F.Nóbrega-Pereira, SandrinaJesus, Bruno Bernardes deinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-01-20T01:48:13Zoai:ria.ua.pt:10773/43455Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:40:34.192405Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv NORAD-regulated signaling pathways in breast cancer progression
title NORAD-regulated signaling pathways in breast cancer progression
spellingShingle NORAD-regulated signaling pathways in breast cancer progression
Capela, Ana Maria
LncRNAs
NORAD
Pumilio
Breast cancer
Chemotherapy resistance
title_short NORAD-regulated signaling pathways in breast cancer progression
title_full NORAD-regulated signaling pathways in breast cancer progression
title_fullStr NORAD-regulated signaling pathways in breast cancer progression
title_full_unstemmed NORAD-regulated signaling pathways in breast cancer progression
title_sort NORAD-regulated signaling pathways in breast cancer progression
author Capela, Ana Maria
author_facet Capela, Ana Maria
Tavares-Marcos, Carlota
Estima-Arede, Hugo F.
Nóbrega-Pereira, Sandrina
Jesus, Bruno Bernardes de
author_role author
author2 Tavares-Marcos, Carlota
Estima-Arede, Hugo F.
Nóbrega-Pereira, Sandrina
Jesus, Bruno Bernardes de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Capela, Ana Maria
Tavares-Marcos, Carlota
Estima-Arede, Hugo F.
Nóbrega-Pereira, Sandrina
Jesus, Bruno Bernardes de
dc.subject.por.fl_str_mv LncRNAs
NORAD
Pumilio
Breast cancer
Chemotherapy resistance
topic LncRNAs
NORAD
Pumilio
Breast cancer
Chemotherapy resistance
description Long non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD's extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this pathology. Through the preferential binding to pumilio (PUM) proteins PUM1 and PUM2, NORAD has been shown to be involved in the control of cell cycle, angiogenesis, mitosis, DNA replication and transcription and protein translation. More recently, NORAD has been associated with PUM-independent roles, accomplished by interacting with other ncRNAs, mRNAs and proteins. The intricate network of NORAD-mediated signaling pathways may provide insights into the potential design of novel unexplored strategies to overcome chemotherapy resistance in BC treatment.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-01T00:00:00Z
2024-02-01
2025-01-16T09:38:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/43455
url http://hdl.handle.net/10773/43455
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
10.3390/cancers16030636
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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