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Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique

Bibliographic Details
Main Author: Garrine, Marcelino
Publication Date: 2024
Other Authors: Andrade, Mariana, Neves, Joana, Mandomando, Inácio, Couto, Isabel, Costa, Sofia Santos
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/169394
Summary: Funding Information: This study was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020 and to the Project DREBI, Ref. 2022.07931.PTDC ( https://doi.org/10.54499/2022.07931.PTDC ). CISM receives core funding from \u201CAgencia Espa\u00F1ola de Cooperacion Internacional para el Desarollo (AECID)\u201D. MG was supported by grant 145278, from Funda\u00E7\u00E3o Calouste Gulbenkian \u201CCalouste Gulbenkian Foundation, Portugal\u201D. MA was supported by grant UI/BD/154472/2022 and JN by grant 2022.07931.PTDC from FCT, Portugal. SSC was supported by FCT through CEECINST/00042/2021/CP1773/CT0009 ( https://doi.org/10.54499/CEECINST/00042/2021/CP1773/CT0009 ). Publisher Copyright: © The Author(s) 2024.
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spelling Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, MozambiqueInfectious DiseasesPediatrics, Perinatology, and Child HealthImmunology and Microbiology(all)Microbiology (medical)SDG 3 - Good Health and Well-beingFunding Information: This study was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020 and to the Project DREBI, Ref. 2022.07931.PTDC ( https://doi.org/10.54499/2022.07931.PTDC ). CISM receives core funding from \u201CAgencia Espa\u00F1ola de Cooperacion Internacional para el Desarollo (AECID)\u201D. MG was supported by grant 145278, from Funda\u00E7\u00E3o Calouste Gulbenkian \u201CCalouste Gulbenkian Foundation, Portugal\u201D. MA was supported by grant UI/BD/154472/2022 and JN by grant 2022.07931.PTDC from FCT, Portugal. SSC was supported by FCT through CEECINST/00042/2021/CP1773/CT0009 ( https://doi.org/10.54499/CEECINST/00042/2021/CP1773/CT0009 ). Publisher Copyright: © The Author(s) 2024.Staphylococcus aureus is a frequent agent of bacteraemia. This bacterium has a variety of virulence traits that allow the establishment and maintenance of infection. This study explored the virulence profile of S. aureus strains causing paediatric bacteraemia (SAB) in Manhiça district, Mozambique. We analysed 336 S. aureus strains isolated from blood cultures of children younger than 5 years admitted to the Manhiça District Hospital between 2001 and 2019, previously characterized for antibiotic susceptibility and clonality. The strains virulence potential was evaluated by PCR detection of the Panton-Valentine leucocidin (PVL) encoding genes, lukS-PV/lukF-PV, assessment of the capacity for biofilm formation and pathogenicity assays in Galleria mellonella. The overall carriage of PVL-encoding genes was over 40%, although reaching ~ 70 to 100% in the last years (2014 to 2019), potentially linked to the emergence of CC152 lineage. Strong biofilm production was a frequent trait of CC152 strains. Representative CC152 and CC121 strains showed higher virulence potential in the G. mellonella model when compared to reference strains, with variations within and between CCs. Our results highlight the importance of monitoring the emergent CC152-MSSA-PVL+ and other lineages, as they display important virulence traits that may negatively impact the management of SAB paediatric patients in Manhiça district, Mozambique.TB, HIV and opportunistic diseases and pathogens (THOP)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)RUNGarrine, MarcelinoAndrade, MarianaNeves, JoanaMandomando, InácioCouto, IsabelCosta, Sofia Santos2024-07-05T22:19:13Z2024-122024-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/169394eng2045-2322PURE: 93291701https://doi.org/10.1038/s41598-024-61345-3info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-31T01:52:58Zoai:run.unl.pt:10362/169394Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T18:36:26.733956Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
title Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
spellingShingle Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
Garrine, Marcelino
Infectious Diseases
Pediatrics, Perinatology, and Child Health
Immunology and Microbiology(all)
Microbiology (medical)
SDG 3 - Good Health and Well-being
title_short Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
title_full Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
title_fullStr Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
title_full_unstemmed Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
title_sort Exploring the virulence potential of Staphylococcus aureus CC121 and CC152 lineages related to paediatric community-acquired bacteraemia in Manhiça, Mozambique
author Garrine, Marcelino
author_facet Garrine, Marcelino
Andrade, Mariana
Neves, Joana
Mandomando, Inácio
Couto, Isabel
Costa, Sofia Santos
author_role author
author2 Andrade, Mariana
Neves, Joana
Mandomando, Inácio
Couto, Isabel
Costa, Sofia Santos
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv TB, HIV and opportunistic diseases and pathogens (THOP)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
RUN
dc.contributor.author.fl_str_mv Garrine, Marcelino
Andrade, Mariana
Neves, Joana
Mandomando, Inácio
Couto, Isabel
Costa, Sofia Santos
dc.subject.por.fl_str_mv Infectious Diseases
Pediatrics, Perinatology, and Child Health
Immunology and Microbiology(all)
Microbiology (medical)
SDG 3 - Good Health and Well-being
topic Infectious Diseases
Pediatrics, Perinatology, and Child Health
Immunology and Microbiology(all)
Microbiology (medical)
SDG 3 - Good Health and Well-being
description Funding Information: This study was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT, Portugal) through funds to GHTM\u2014UID/04413/2020, LA-REAL\u2014LA/P/0117/2020 and to the Project DREBI, Ref. 2022.07931.PTDC ( https://doi.org/10.54499/2022.07931.PTDC ). CISM receives core funding from \u201CAgencia Espa\u00F1ola de Cooperacion Internacional para el Desarollo (AECID)\u201D. MG was supported by grant 145278, from Funda\u00E7\u00E3o Calouste Gulbenkian \u201CCalouste Gulbenkian Foundation, Portugal\u201D. MA was supported by grant UI/BD/154472/2022 and JN by grant 2022.07931.PTDC from FCT, Portugal. SSC was supported by FCT through CEECINST/00042/2021/CP1773/CT0009 ( https://doi.org/10.54499/CEECINST/00042/2021/CP1773/CT0009 ). Publisher Copyright: © The Author(s) 2024.
publishDate 2024
dc.date.none.fl_str_mv 2024-07-05T22:19:13Z
2024-12
2024-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/169394
url http://hdl.handle.net/10362/169394
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
PURE: 93291701
https://doi.org/10.1038/s41598-024-61345-3
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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