Oxalate (dys)Metabolism
| Main Author: | |
|---|---|
| Publication Date: | 2023 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Other |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/158696 |
Summary: | Funding Information: The authors would like to thank the Associação Portuguesa de Urologia, for funding the project “Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome Traits and Recurrent Nephrolithiasis—Metabolomics and Recurrence Assessment”. iNOVA4Health research program (UIDP/04462/2020) is also acknowledged to support Judit Morello. Publisher Copyright: © 2023 by the authors. |
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Oxalate (dys)MetabolismPerson-to-Person Variability, Kidney and Cardiometabolic Toxicitycardiovascular diseasehyperoxaluriahypertensionkidney diseasekidney stonesmetabolic diseasemicrobiotanephrolithiasisobstructive sleep apneapharmacologysystemic inflammationGeneticsGenetics(clinical)SDG 3 - Good Health and Well-beingFunding Information: The authors would like to thank the Associação Portuguesa de Urologia, for funding the project “Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome Traits and Recurrent Nephrolithiasis—Metabolomics and Recurrence Assessment”. iNOVA4Health research program (UIDP/04462/2020) is also acknowledged to support Judit Morello. Publisher Copyright: © 2023 by the authors.Oxalate is a metabolic end-product whose systemic concentrations are highly variable among individuals. Genetic (primary hyperoxaluria) and non-genetic (e.g., diet, microbiota, renal and metabolic disease) reasons underlie elevated plasma concentrations and tissue accumulation of oxalate, which is toxic to the body. A classic example is the triad of primary hyperoxaluria, nephrolithiasis, and kidney injury. Lessons learned from this example suggest further investigation of other putative factors associated with oxalate dysmetabolism, namely the identification of precursors (glyoxylate, aromatic amino acids, glyoxal and vitamin C), the regulation of the endogenous pathways that produce oxalate, or the microbiota’s contribution to oxalate systemic availability. The association between secondary nephrolithiasis and cardiovascular and metabolic diseases (hypertension, type 2 diabetes, and obesity) inspired the authors to perform this comprehensive review about oxalate dysmetabolism and its relation to cardiometabolic toxicity. This perspective may offer something substantial that helps advance understanding of effective management and draws attention to the novel class of treatments available in clinical practice.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)iNOVA4Health - pólo NMSComprehensive Health Research Centre (CHRC) - pólo NMSCentre for Toxicogenomics and Human Health (ToxOmics)RUNBaltazar, Pedrode Melo Junior, Antonio FerreiraFonseca, Nuno MoreiraLança, Miguel BritoFaria, AnaSequeira, Catarina O.Teixeira-Santos, LuísaMonteiro, Emilia C.Campos Pinheiro, LuísCalado, JoaquimSousa, CátiaMorello, JuditPereira, Sofia A.2023-10-04T22:19:07Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/158696eng0920-8569PURE: 73136847https://doi.org/10.3390/genes14091719info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:14:57Zoai:run.unl.pt:10362/158696Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:45:27.073674Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Oxalate (dys)Metabolism Person-to-Person Variability, Kidney and Cardiometabolic Toxicity |
| title |
Oxalate (dys)Metabolism |
| spellingShingle |
Oxalate (dys)Metabolism Baltazar, Pedro cardiovascular disease hyperoxaluria hypertension kidney disease kidney stones metabolic disease microbiota nephrolithiasis obstructive sleep apnea pharmacology systemic inflammation Genetics Genetics(clinical) SDG 3 - Good Health and Well-being |
| title_short |
Oxalate (dys)Metabolism |
| title_full |
Oxalate (dys)Metabolism |
| title_fullStr |
Oxalate (dys)Metabolism |
| title_full_unstemmed |
Oxalate (dys)Metabolism |
| title_sort |
Oxalate (dys)Metabolism |
| author |
Baltazar, Pedro |
| author_facet |
Baltazar, Pedro de Melo Junior, Antonio Ferreira Fonseca, Nuno Moreira Lança, Miguel Brito Faria, Ana Sequeira, Catarina O. Teixeira-Santos, Luísa Monteiro, Emilia C. Campos Pinheiro, Luís Calado, Joaquim Sousa, Cátia Morello, Judit Pereira, Sofia A. |
| author_role |
author |
| author2 |
de Melo Junior, Antonio Ferreira Fonseca, Nuno Moreira Lança, Miguel Brito Faria, Ana Sequeira, Catarina O. Teixeira-Santos, Luísa Monteiro, Emilia C. Campos Pinheiro, Luís Calado, Joaquim Sousa, Cátia Morello, Judit Pereira, Sofia A. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) iNOVA4Health - pólo NMS Comprehensive Health Research Centre (CHRC) - pólo NMS Centre for Toxicogenomics and Human Health (ToxOmics) RUN |
| dc.contributor.author.fl_str_mv |
Baltazar, Pedro de Melo Junior, Antonio Ferreira Fonseca, Nuno Moreira Lança, Miguel Brito Faria, Ana Sequeira, Catarina O. Teixeira-Santos, Luísa Monteiro, Emilia C. Campos Pinheiro, Luís Calado, Joaquim Sousa, Cátia Morello, Judit Pereira, Sofia A. |
| dc.subject.por.fl_str_mv |
cardiovascular disease hyperoxaluria hypertension kidney disease kidney stones metabolic disease microbiota nephrolithiasis obstructive sleep apnea pharmacology systemic inflammation Genetics Genetics(clinical) SDG 3 - Good Health and Well-being |
| topic |
cardiovascular disease hyperoxaluria hypertension kidney disease kidney stones metabolic disease microbiota nephrolithiasis obstructive sleep apnea pharmacology systemic inflammation Genetics Genetics(clinical) SDG 3 - Good Health and Well-being |
| description |
Funding Information: The authors would like to thank the Associação Portuguesa de Urologia, for funding the project “Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome Traits and Recurrent Nephrolithiasis—Metabolomics and Recurrence Assessment”. iNOVA4Health research program (UIDP/04462/2020) is also acknowledged to support Judit Morello. Publisher Copyright: © 2023 by the authors. |
| publishDate |
2023 |
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2023-10-04T22:19:07Z 2023-09 2023-09-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/other |
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other |
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http://hdl.handle.net/10362/158696 |
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http://hdl.handle.net/10362/158696 |
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eng |
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eng |
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0920-8569 PURE: 73136847 https://doi.org/10.3390/genes14091719 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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