Extracellular vesicle proteome in prostate cancer

Bibliographic Details
Main Author: Bernardino, Rui Miguel Marques
Publication Date: 2021
Other Authors: Leão, Ricardo, Henrique, Rui, Pinheiro, Luis Campos, Kumar, Prashant, Suravajhala, Prashanth, Beck, Hans Christian, Carvalho, Ana Sofia, Matthiesen, Rune
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/130894
Summary: Funding Information: Funding: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects number PTDC/BTM-TEC/30087/2017 and PTDC/BTM-TEC/30088/2017. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
id RCAP_01c0e9a033d3fbd4f2a40e0cf128ccea
oai_identifier_str oai:run.unl.pt:10362/130894
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Extracellular vesicle proteome in prostate cancerA comparative analysis of mass spectrometry studiesBiomarkersExtracellular vesicles (EVs)Prostate cancerProteomicsUrine extracellular vesicles (uEVs)CatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: Funding: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects number PTDC/BTM-TEC/30087/2017 and PTDC/BTM-TEC/30088/2017. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Molecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly ex-plored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. Therefore, in this study, we aim to inquire about possible strategies for urinary biomarker discovery particularly focused on the proteome of urine EVs. Proteomics data deposited in the PRIDE archive were reanalyzed to target identifications of potential PCa markers. Network analysis of the markers proposed by different prostate cancer studies revealed moderate overlap. The recent throughput improvements in mass spectrometry together with the network analysis performed in this study, suggest that a larger standardized cohort may provide potential biomarkers that are able to fully characterize the heterogeneity of PCa. According to our analysis PCa studies based on urinary EV proteome presents higher protein coverage compared to plasma, plasma EV, and voided urine proteome. This together with a direct interaction of the prostate gland and urethra makes uEVs an attractive option for protein biomarker studies. In addition, urinary proteome based PCa studies must also evaluate samples from bladder and renal cancers to assess specificity for PCa.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNBernardino, Rui Miguel MarquesLeão, RicardoHenrique, RuiPinheiro, Luis CamposKumar, PrashantSuravajhala, PrashanthBeck, Hans ChristianCarvalho, Ana SofiaMatthiesen, Rune2022-01-15T03:30:21Z2021-12-012021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/130894eng1661-6596PURE: 35620864https://doi.org/10.3390/ijms222413605info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:58:09Zoai:run.unl.pt:10362/130894Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:29:22.581882Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Extracellular vesicle proteome in prostate cancer
A comparative analysis of mass spectrometry studies
title Extracellular vesicle proteome in prostate cancer
spellingShingle Extracellular vesicle proteome in prostate cancer
Bernardino, Rui Miguel Marques
Biomarkers
Extracellular vesicles (EVs)
Prostate cancer
Proteomics
Urine extracellular vesicles (uEVs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short Extracellular vesicle proteome in prostate cancer
title_full Extracellular vesicle proteome in prostate cancer
title_fullStr Extracellular vesicle proteome in prostate cancer
title_full_unstemmed Extracellular vesicle proteome in prostate cancer
title_sort Extracellular vesicle proteome in prostate cancer
author Bernardino, Rui Miguel Marques
author_facet Bernardino, Rui Miguel Marques
Leão, Ricardo
Henrique, Rui
Pinheiro, Luis Campos
Kumar, Prashant
Suravajhala, Prashanth
Beck, Hans Christian
Carvalho, Ana Sofia
Matthiesen, Rune
author_role author
author2 Leão, Ricardo
Henrique, Rui
Pinheiro, Luis Campos
Kumar, Prashant
Suravajhala, Prashanth
Beck, Hans Christian
Carvalho, Ana Sofia
Matthiesen, Rune
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Bernardino, Rui Miguel Marques
Leão, Ricardo
Henrique, Rui
Pinheiro, Luis Campos
Kumar, Prashant
Suravajhala, Prashanth
Beck, Hans Christian
Carvalho, Ana Sofia
Matthiesen, Rune
dc.subject.por.fl_str_mv Biomarkers
Extracellular vesicles (EVs)
Prostate cancer
Proteomics
Urine extracellular vesicles (uEVs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic Biomarkers
Extracellular vesicles (EVs)
Prostate cancer
Proteomics
Urine extracellular vesicles (uEVs)
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: Funding: R.M. is supported by Fundação para a Ciência e a Tecnologia (CEEC position, 2019–2025 investigator). This article is a result of the projects (iNOVA4Health—UIDB/04462/2020), supported by Lisboa Portugal Regional Operational Programme (Lisboa2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work is also funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT—Portuguese Foundation for Science and Technology under the projects number PTDC/BTM-TEC/30087/2017 and PTDC/BTM-TEC/30088/2017. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-01
2021-12-01T00:00:00Z
2022-01-15T03:30:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/130894
url http://hdl.handle.net/10362/130894
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 35620864
https://doi.org/10.3390/ijms222413605
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596729568526336

Similar Items