Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise

Bibliographic Details
Main Author: Famadas, Luiz Carlos
Publication Date: 2023
Format: Article
Language: por
Source: Revista Brasileira de Cancerologia (Online)
Download full: https://rbc.inca.gov.br/index.php/revista/article/view/3538
Summary: The author comments on diagnostic difficulties of disseminated intravascular coagulation (DIC and fibrinolisis (F) and suggests a compact laboratory work up necessary to diagnosis in both disturbances. Enphasis is placed on the therapeutic approach of patients with DIC and F, stressing the following points: 1) Removal of etiological factors and restoration of blood volume are the two main concerns. 2) infusions of coagulation factors and platelets are not important; the infusion of fibrinogen concentrate is contraindicated. 3) Heparin and antifibrinolitics are usually administered to patients with chronic DIC and F prior to surgical procedures to eliminate causative pathology. 4) Fibrin and fibrinogen degradation Products do persist in circulation above hemostatic levels for a few hours after the causative pathology has been removed. Bleeding during this period does not demand specific treatment except for maintenance of blood volume.
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spelling Conduta Terapêutica na Coagulação Intravascular Disseminada e na FibrinóliseCoagulação Intravascular DisseminadaFibrinóliseTécnicas de Laboratório ClínicoDisseminated Intravascular CoagulationFibrinolysisClinical Laboratory TechniquesCoagulación Intravascular DiseminadaFibrinólisisTécnicas de Laboratorio ClínicoThe author comments on diagnostic difficulties of disseminated intravascular coagulation (DIC and fibrinolisis (F) and suggests a compact laboratory work up necessary to diagnosis in both disturbances. Enphasis is placed on the therapeutic approach of patients with DIC and F, stressing the following points: 1) Removal of etiological factors and restoration of blood volume are the two main concerns. 2) infusions of coagulation factors and platelets are not important; the infusion of fibrinogen concentrate is contraindicated. 3) Heparin and antifibrinolitics are usually administered to patients with chronic DIC and F prior to surgical procedures to eliminate causative pathology. 4) Fibrin and fibrinogen degradation Products do persist in circulation above hemostatic levels for a few hours after the causative pathology has been removed. Bleeding during this period does not demand specific treatment except for maintenance of blood volume.O autor faz comentários sobre a dificuldade no diagnóstico de coagulação intravascular disseminada (ClD) e fibrinólise (F) e apresenta a rotina laboratorial mínima para caracterização desses dois distúrbios hemostáticos. Detém-se mais na conduta terapêutica dos pacientes com os referidos distúrbios, salientando que: 1). O afastamento da causa e a reposição volêmica devem ser as principais preocupações. 2) As infusões de fatores de coagulação e de plaquetas não são importantes e a administração de concentrado de fibrinogênio está contra-indicada. 3) A heparina e os antifibrinolíticos são administrados aos pacientes com Cl D e F crônicas dos procedimentos cirúrgicos para eliminar a causa. 4) Salienta o autor que, mesmo depois de afastada a causa, o sangramento deve persistir por algumas horas até que os produtos de degradação da fibrina e fibrinogênio não impeçam a hemostasia.INCA2023-08-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/353810.32635/2176-9745.RBC.1982v29n2.3538Revista Brasileira de Cancerologia; Vol. 29 No. 2 (1982): Dec.; 38-41Revista Brasileira de Cancerologia; Vol. 29 Núm. 2 (1982): dic.; 38-41Revista Brasileira de Cancerologia; v. 29 n. 2 (1982): dez.; 38-412176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3538/2405https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFamadas, Luiz Carlos2023-08-10T20:33:43Zoai:rbc.inca.gov.br:article/3538Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-08-10T20:33:43Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
title Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
spellingShingle Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
Famadas, Luiz Carlos
Coagulação Intravascular Disseminada
Fibrinólise
Técnicas de Laboratório Clínico
Disseminated Intravascular Coagulation
Fibrinolysis
Clinical Laboratory Techniques
Coagulación Intravascular Diseminada
Fibrinólisis
Técnicas de Laboratorio Clínico
title_short Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
title_full Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
title_fullStr Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
title_full_unstemmed Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
title_sort Conduta Terapêutica na Coagulação Intravascular Disseminada e na Fibrinólise
author Famadas, Luiz Carlos
author_facet Famadas, Luiz Carlos
author_role author
dc.contributor.author.fl_str_mv Famadas, Luiz Carlos
dc.subject.por.fl_str_mv Coagulação Intravascular Disseminada
Fibrinólise
Técnicas de Laboratório Clínico
Disseminated Intravascular Coagulation
Fibrinolysis
Clinical Laboratory Techniques
Coagulación Intravascular Diseminada
Fibrinólisis
Técnicas de Laboratorio Clínico
topic Coagulação Intravascular Disseminada
Fibrinólise
Técnicas de Laboratório Clínico
Disseminated Intravascular Coagulation
Fibrinolysis
Clinical Laboratory Techniques
Coagulación Intravascular Diseminada
Fibrinólisis
Técnicas de Laboratorio Clínico
description The author comments on diagnostic difficulties of disseminated intravascular coagulation (DIC and fibrinolisis (F) and suggests a compact laboratory work up necessary to diagnosis in both disturbances. Enphasis is placed on the therapeutic approach of patients with DIC and F, stressing the following points: 1) Removal of etiological factors and restoration of blood volume are the two main concerns. 2) infusions of coagulation factors and platelets are not important; the infusion of fibrinogen concentrate is contraindicated. 3) Heparin and antifibrinolitics are usually administered to patients with chronic DIC and F prior to surgical procedures to eliminate causative pathology. 4) Fibrin and fibrinogen degradation Products do persist in circulation above hemostatic levels for a few hours after the causative pathology has been removed. Bleeding during this period does not demand specific treatment except for maintenance of blood volume.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3538
10.32635/2176-9745.RBC.1982v29n2.3538
url https://rbc.inca.gov.br/index.php/revista/article/view/3538
identifier_str_mv 10.32635/2176-9745.RBC.1982v29n2.3538
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/3538/2405
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 29 No. 2 (1982): Dec.; 38-41
Revista Brasileira de Cancerologia; Vol. 29 Núm. 2 (1982): dic.; 38-41
Revista Brasileira de Cancerologia; v. 29 n. 2 (1982): dez.; 38-41
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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