Ação de Sais de Cobre sobre a Xantina Desidrogenase na Carcinogênese Hepática de Ratas

• Main Author: Affonso, Ottilia R.
• Publication Date: 2023
• Other Authors: Souza, Arthurs. R., Kwee, Jolie K., Asch, Karen H., Mitidieri, Emílio
• Format: Article
• Language: por
• Source: Revista Brasileira de Cancerologia (Online)
• Download full: https://rbc.inca.gov.br/index.php/revista/article/view/3465
• topic: Sais de Cobre; Xantina Desidrogenase; Carcinogênese; Xanthine Dehydrogenase; Carcinogenesis

Blood serum xanthine dehydrogenase activity was inhibited by cupric acetate (CuAc) (12,5 mg/100 g body weight). The study of the inhibition by CuAc was related with the hepatic changes produced by D-L-ethionine (12,5 mg/100 g body weight). "In vitro" experiments showed that CuAc is a potent inhibitor of the xanthine dehydrogenase activity and that this inhibition is of a non-competitive type. Ehtionine protects against the inhibitory effect of CuAc, both "m vivo" as "in vitro", probably by the formation of a copper complex. Experiments with O2 as eléctron acceptor seemed to indicate that the cupric sait competes "m vitro" with the reduction of the triphenyltetrazolium chloride in the electron transfer reaction.