Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon: a population-based panel study

• Main Author: Paula, Fabiana Martins de
• Publication Date: 2025
• Other Authors: Gomes, Bruna Barroso, Meisel, Dirce Mary Correia Lima, Roldan, William Henry, Nunes, Mônica da Silva, Ferreira, Marcelo Urbano, Gryschek, Ronaldo Cesar Borges
• Format: Article
• Language: eng
• Source: Revista do Instituto de Medicina Tropical de São Paulo
• Download full: https://www.revistas.usp.br/rimtsp/article/view/233355
• topic: Strongyloides; Serology; Seroconversion; Seroreversion; Brazil

Using a panel study design, we aimed to estimate the seroconversion and seroreversion rates of anti-Strongyloides IgG antibodies from surveys carried out 11 months apart in a rural community in the Amazon Basin in Brazil. We used enzyme immunoassays to measure anti-Strongyloides IgG antibodies in 325 baseline plasma samples and 224 others that were collected 11 months later from residents in the agricultural settlement of Granada, Acre State. We observed anti-Strongyloides IgG antibodies in 21.8% of the baseline samples (which showed that 3.4% of participants had larvae in their stool) and in 23.7% of the follow-up samples. The seroconversion rate estimated at 9.7 episodes/100 person-years at risk agrees with ongoing transmission. Specific antibodies were relatively short-lived and nine (25.0%) of 36 seropositive participants at baseline were seronegative when retested 11 months later. Fecal surveys can severely underestimate the prevalence of S. stercoralis infection in rural Amazonians. Serology provides a field-deployable diagnostic tool to find high-prevalence populations, identify associated risk factors, and monitor intervention programs.