Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis

Bibliographic Details
Main Author: Restrepo, Susana
Publication Date: 1992
Other Authors: Tabares, Angela M., Restrepo, Angela
Format: Article
Language: eng
Source: Revista do Instituto de Medicina Tropical de São Paulo
Download full: https://www.revistas.usp.br/rimtsp/article/view/28912
Summary: A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis
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spelling Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis Activity of two different triazoles in a murine model of paracoccidioidomycosis ParacoccidioidomycosisExperimentalTreatmentTriazoleItraconazolSchering 39304 A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis Un nuevo derivado triazólico Schering 39304 que tiene una vida promedio prolongada (60 horas), asi como otro triazol (itraconazole) de eficacia comprobada en la paracoccidioidomicosis, fueron ensayados en un modelo murino. Se encontró que solo sobrevivían el 15% de los animales infectados no tratados; del grupo tratado con Itrazonazol sobrevivieron el 53% de los que recibieron 20 mg/kg/dia y el 86% de aquellos con 50 mg/kg/dia. De los ratones que recibieron Sch 39304 sobrevivieron el 86% de los tratados con la dosis baja (5 mg/kg) y el 100% con la dosis mayor (20 mg/kg). Se encontraron diferencias estadísticamente significativas entre esta última droga y el itraconazol. Además, los cultivos de pulmón mostraron que solo Sch 39304 a la dosis alta, era capaz de erradicar el hongo de los tejidos. Estos resultados indican que tal triazol tendrá importancia en el tratamiento de la paracoccidioidomicosis humana Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28912Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 171-176 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 171-176 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 171-176 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28912/30767Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRestrepo, SusanaTabares, Angela M.Restrepo, Angela2012-07-02T01:32:48Zoai:revistas.usp.br:article/28912Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2012-07-02T01:32:48Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
Activity of two different triazoles in a murine model of paracoccidioidomycosis
title Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
spellingShingle Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
Restrepo, Susana
Paracoccidioidomycosis
Experimental
Treatment
Triazole
Itraconazol
Schering 39304
title_short Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
title_full Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
title_fullStr Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
title_full_unstemmed Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
title_sort Actividad de dos triazoles diferentes en un modelo murino de paracoccidioidomicosis
author Restrepo, Susana
author_facet Restrepo, Susana
Tabares, Angela M.
Restrepo, Angela
author_role author
author2 Tabares, Angela M.
Restrepo, Angela
author2_role author
author
dc.contributor.author.fl_str_mv Restrepo, Susana
Tabares, Angela M.
Restrepo, Angela
dc.subject.por.fl_str_mv Paracoccidioidomycosis
Experimental
Treatment
Triazole
Itraconazol
Schering 39304
topic Paracoccidioidomycosis
Experimental
Treatment
Triazole
Itraconazol
Schering 39304
description A new orally absorbable triazole (Schering 39304) with a long serum half-life in man (60 hours), was tried in a murine model of progressive paracoccidioidomycosis and compared with itraconazole, another triazole which has proven effective in this mycosis. Only 15% of the infected, untreated mice survived while 53 to 75% of the animals receiving itraconazole survived. Mice treated with Schering 39304 exhibited higher (86 - 100%) survival rates. Statistically, the 5 mg/kg Sch 39304 was superior to the 50 mg/kg itraconazole dose. Lung cultures showed that 20 mg/kg/day of Sch achieved sterilization of the infectious foci. These results indicate that the new triazole will have a place in the treatment of paracoccidioidomycosis
publishDate 1992
dc.date.none.fl_str_mv 1992-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28912
url https://www.revistas.usp.br/rimtsp/article/view/28912
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28912/30767
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 171-176
Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 171-176
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 171-176
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
_version_ 1825138385526718464

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