Enterolobin induces rat paw oedema independently of PAF-acether

Bibliographic Details
Main Author: Castro Faria Neto,H. C.
Publication Date: 1991
Other Authors: Cordeiro,R. S. B., Martins,M. A., Correia da Silva,A. C. V., Bozza,P. T., Sousa,M. V., Morhy,L.
Format: Article
Language: eng
Source: Memórias do Instituto Oswaldo Cruz
Download full: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600029
Summary: The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
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spelling Enterolobin induces rat paw oedema independently of PAF-acethertoxic proteinsPAFpaw oedemaThe potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.Instituto Oswaldo Cruz, Ministério da Saúde1991-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600029Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761991000600029info:eu-repo/semantics/openAccessCastro Faria Neto,H. C.Cordeiro,R. S. B.Martins,M. A.Correia da Silva,A. C. V.Bozza,P. T.Sousa,M. V.Morhy,L.eng2020-04-25T17:46:40Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:04:18.162Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Enterolobin induces rat paw oedema independently of PAF-acether
title Enterolobin induces rat paw oedema independently of PAF-acether
spellingShingle Enterolobin induces rat paw oedema independently of PAF-acether
Castro Faria Neto,H. C.
toxic proteins
PAF
paw oedema
title_short Enterolobin induces rat paw oedema independently of PAF-acether
title_full Enterolobin induces rat paw oedema independently of PAF-acether
title_fullStr Enterolobin induces rat paw oedema independently of PAF-acether
title_full_unstemmed Enterolobin induces rat paw oedema independently of PAF-acether
title_sort Enterolobin induces rat paw oedema independently of PAF-acether
author Castro Faria Neto,H. C.
author_facet Castro Faria Neto,H. C.
Cordeiro,R. S. B.
Martins,M. A.
Correia da Silva,A. C. V.
Bozza,P. T.
Sousa,M. V.
Morhy,L.
author_role author
author2 Cordeiro,R. S. B.
Martins,M. A.
Correia da Silva,A. C. V.
Bozza,P. T.
Sousa,M. V.
Morhy,L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro Faria Neto,H. C.
Cordeiro,R. S. B.
Martins,M. A.
Correia da Silva,A. C. V.
Bozza,P. T.
Sousa,M. V.
Morhy,L.
dc.subject.por.fl_str_mv toxic proteins
PAF
paw oedema
topic toxic proteins
PAF
paw oedema
dc.description.none.fl_txt_mv The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
description The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.
publishDate 1991
dc.date.none.fl_str_mv 1991-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600029
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761991000600029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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