Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis

Bibliographic Details
Main Author: Piedade, Juliana
Publication Date: 2022
Other Authors: Guimarães, Livia, Duarte, Joana, Gouveia, Lorena, Garfinkel, Tamar, Veiga, Zulane, Alcântara, Camila, Perazzo, Hugo, Fernandes, Flavia, Pereira, Gustavo
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.5114/ceh.2022.120030
Download full: https://arca.fiocruz.br/handle/icict/59515
Summary: Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.
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spelling Piedade, JulianaGuimarães, LiviaDuarte, JoanaGouveia, LorenaGarfinkel, TamarVeiga, ZulaneAlcântara, CamilaPerazzo, HugoFernandes, FlaviaPereira, Gustavo2023-07-11T18:48:41Z2023-07-11T18:48:41Z2022PIEDADE, Juliana et al. Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology, v. 8, n. 4, p. 284-292, Dec. 2022.2392-1099https://arca.fiocruz.br/handle/icict/5951510.5114/ceh.2022.1200302449-8238engTermedia Publishing HouseFrequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Estácio de Sá University. School of Medicine. Institute of Medical Education. Rio de Janeiro, RJ, Brazil.Estácio de Sá University. School of Medicine. Institute of Medical Education. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil / Estácio de Sá University. School of Medicine. Institute of Medical Education. Rio de Janeiro, RJ, Brazil.Introduction: Data of minimal hepatic encephalopathy (MHE) before and after hepatitis C virus (HCV) treatment remain scarce. We aimed to describe the prevalence, evolution and predictive factors of MHE before and after a sustained virological response (SVR). Material and methods: It was a prospective study that included adults with cirrhosis due to HCV treated by direct-acting agents (DAA). MHE was assessed using the Psychometric Hepatic Encephalopathy Score (PHES). Results: 104 patients (65% female, age 60 ±10 years; 69% with diabetes, 47% with hypertension; 82% ChildPugh A) were included. MHE was assessed just before therapy and 12 (IQR 7-15) months after SVR. Prevalence of MHE before HCV treatment and after SVR were 16% and 22%, respectively (p = 0.18). Resolution of MHE after SVR occurred in afew patients (n = 4/17) and 10 of 87 patients (11.5%) without MHE before treatment developed this condition after SVR. MHE after SVR was more common in patients with MHE before treatment (57% vs. 5%, p < 0.001). In multivariate analysis, older age, hypertension and hypoalbuminemia after treatment were predictors of MHE after SVR. In the absence of all these variables, none of the patients had MHE. In contrast, the prevalence of MHE was 42% and 70% in the case of presence of any 2 of these factors and all these conditions, respectively. Conclusions: MHE is frequent in patients with cirrhosis who achieved SVR after DAA. SVR is associated with low probability of resolution of MHE and may not entirely protect patients from developing de novo MHE. Presence of MHE before DAA, older age, hypertension and hypoalbuminemia after SVR were independently associated with this condition.Hepatic EncephalopathySustained Virologic ResponseHepatitis CLiver Cirrhosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Juliana_Piedade_etal_INI_2022.pdfve_Juliana_Piedade_etal_INI_2022.pdfapplication/pdf129177https://arca.fiocruz.br/bitstreams/371d2db1-6290-47dc-9924-5dc82e32c36b/download7749b08f898145e4674061b85d9f4246MD52trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/634b567e-e6a8-4d7a-8ea3-953ff4971665/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADTEXTve_Juliana_Piedade_etal_INI_2022.pdf.txtve_Juliana_Piedade_etal_INI_2022.pdf.txtExtracted texttext/plain40379https://arca.fiocruz.br/bitstreams/ec59ad32-4fbc-4aae-b494-ccafab5b97c6/download7e0a45db4bbefaa54a7995693e7295e2MD55falseAnonymousREADTHUMBNAILve_Juliana_Piedade_etal_INI_2022.pdf.jpgve_Juliana_Piedade_etal_INI_2022.pdf.jpgGenerated Thumbnailimage/jpeg5563https://arca.fiocruz.br/bitstreams/ffcced19-6dad-4552-895e-f8c1d8f48c76/downloadc125bc51be20120635839c6d43019e52MD56falseAnonymousREADicict/595152025-07-29 23:24:21.46open.accessoai:arca.fiocruz.br:icict/59515https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T02:24:21Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
title Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
spellingShingle Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
Piedade, Juliana
Hepatic Encephalopathy
Sustained Virologic Response
Hepatitis C
Liver Cirrhosis
title_short Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
title_full Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
title_fullStr Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
title_full_unstemmed Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
title_sort Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis
author Piedade, Juliana
author_facet Piedade, Juliana
Guimarães, Livia
Duarte, Joana
Gouveia, Lorena
Garfinkel, Tamar
Veiga, Zulane
Alcântara, Camila
Perazzo, Hugo
Fernandes, Flavia
Pereira, Gustavo
author_role author
author2 Guimarães, Livia
Duarte, Joana
Gouveia, Lorena
Garfinkel, Tamar
Veiga, Zulane
Alcântara, Camila
Perazzo, Hugo
Fernandes, Flavia
Pereira, Gustavo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Piedade, Juliana
Guimarães, Livia
Duarte, Joana
Gouveia, Lorena
Garfinkel, Tamar
Veiga, Zulane
Alcântara, Camila
Perazzo, Hugo
Fernandes, Flavia
Pereira, Gustavo
dc.subject.en.none.fl_str_mv Hepatic Encephalopathy
Sustained Virologic Response
Hepatitis C
Liver Cirrhosis
topic Hepatic Encephalopathy
Sustained Virologic Response
Hepatitis C
Liver Cirrhosis
description Ministry of Health. Bonsucesso Federal Hospital. Gastroenterology and Hepatology Unit. Rio de Janeiro, RJ, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-07-11T18:48:41Z
dc.date.available.fl_str_mv 2023-07-11T18:48:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PIEDADE, Juliana et al. Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology, v. 8, n. 4, p. 284-292, Dec. 2022.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/59515
dc.identifier.issn.none.fl_str_mv 2392-1099
dc.identifier.doi.none.fl_str_mv 10.5114/ceh.2022.120030
dc.identifier.eissn.none.fl_str_mv 2449-8238
identifier_str_mv PIEDADE, Juliana et al. Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis. Clinical and Experimental Hepatology, v. 8, n. 4, p. 284-292, Dec. 2022.
2392-1099
10.5114/ceh.2022.120030
2449-8238
url https://arca.fiocruz.br/handle/icict/59515
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Termedia Publishing House
publisher.none.fl_str_mv Termedia Publishing House
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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