Recent advances in the development and clinical application of miRNAs in infectious diseases
| Main Author: | |
|---|---|
| Publication Date: | 2025 |
| Other Authors: | , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.ncrna.2024.09.005 |
| Download full: | https://arca.fiocruz.br/handle/icict/70522 |
Summary: | Fundação de Amparo à Pesquisa do Estado na Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Nunes, SaraBastos, RanaMarinho, Ananda IsisVieira, RaissaBenício, IngraNoronha, Maria Alícia deLírio, SofiaBrodskyn, Claudia IdaTavares, Natalia Machado2025-05-21T14:34:42Z2025-05-21T14:34:42Z2025NUNES, Sara; Bastos, Rana; MARINHO, Ananda Isis; VIEIRA, Raissa; BENÍCIO, Ingra; NORONHA, Maria Alícia de; LÍRIO, Sofia; BRODSKYN, Cláudia; TAVARES, Natalia Machado. Recent advances in the development and clinical application of miRNAs in infectious diseases. Non-coding RNA Research, v.10, p. 1-14, 2025.2468-0540https://arca.fiocruz.br/handle/icict/7052210.1016/j.ncrna.2024.09.005Fundação de Amparo à Pesquisa do Estado na Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasita-Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação Em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Medicina e Saúde Pública de Precisão. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação Em Imunologia. São Paulo, SP, Brasil.In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. Small RNAs, known as microRNAs (miRs), are important regulators of gene expression, and have emerged as promising candidates for these purposes. MiRs are a class of small, endogenous non-coding RNAs that play critical roles in several human diseases, including host-pathogen interaction mechanisms. Recently, miRs signatures have been reported in different infectious diseases, opening new perspectives for molecular diagnosis and therapy. MiR profiles can discriminate between healthy individuals and patients, as well as distinguish different disease stages. Furthermore, the possibility of assessing miRs in biological fluids, such as serum and whole blood, renders these molecules feasible for the development of new non-invasive diagnostic and prognostic tools. In this manuscript, we will comprehensively describe miRs as biomarkers and therapeutic targets in infectious diseases and explore how they can contribute to the advance of existing and new tools. Additionally, we will discuss different miR analysis platforms to understand the obstacles and advances of this molecular approach and propose their potential clinical applications and contributions to public health.engElsevierRecent advances in the development and clinical application of miRNAs in infectious diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlemicroRNAsInfectious diseasesBiomarkersTherapeutic targetsMicroRNAsDoenças TransmissíveisBiomarcadoresinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/636bb63b-7096-4e52-bf67-7ed613fe3fc9/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALNunes, S. Recent advances....pdfNunes, S. Recent advances....pdfapplication/pdf3741134https://arca.fiocruz.br/bitstreams/e8fa7959-52ee-4022-ac4b-1bffbe1c4149/downloadd85f38543b3c660af811f5535fb36accMD52trueAnonymousREADTEXTNunes, S. Recent advances....pdf.txtNunes, S. Recent advances....pdf.txtExtracted texttext/plain100361https://arca.fiocruz.br/bitstreams/187a6cce-90f0-4f1e-9268-b784600868fb/downloadc13f3b9baf8dbc4511ea10dd54b2d05bMD55falseAnonymousREADTHUMBNAILNunes, S. Recent advances....pdf.jpgNunes, S. 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| dc.title.none.fl_str_mv |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| title |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| spellingShingle |
Recent advances in the development and clinical application of miRNAs in infectious diseases Nunes, Sara microRNAs Infectious diseases Biomarkers Therapeutic targets MicroRNAs Doenças Transmissíveis Biomarcadores |
| title_short |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| title_full |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| title_fullStr |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| title_full_unstemmed |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| title_sort |
Recent advances in the development and clinical application of miRNAs in infectious diseases |
| author |
Nunes, Sara |
| author_facet |
Nunes, Sara Bastos, Rana Marinho, Ananda Isis Vieira, Raissa Benício, Ingra Noronha, Maria Alícia de Lírio, Sofia Brodskyn, Claudia Ida Tavares, Natalia Machado |
| author_role |
author |
| author2 |
Bastos, Rana Marinho, Ananda Isis Vieira, Raissa Benício, Ingra Noronha, Maria Alícia de Lírio, Sofia Brodskyn, Claudia Ida Tavares, Natalia Machado |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nunes, Sara Bastos, Rana Marinho, Ananda Isis Vieira, Raissa Benício, Ingra Noronha, Maria Alícia de Lírio, Sofia Brodskyn, Claudia Ida Tavares, Natalia Machado |
| dc.subject.en.none.fl_str_mv |
microRNAs Infectious diseases Biomarkers Therapeutic targets |
| topic |
microRNAs Infectious diseases Biomarkers Therapeutic targets MicroRNAs Doenças Transmissíveis Biomarcadores |
| dc.subject.decs.none.fl_str_mv |
MicroRNAs Doenças Transmissíveis Biomarcadores |
| description |
Fundação de Amparo à Pesquisa do Estado na Bahia (FAPESB). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2025 |
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2025-05-21T14:34:42Z |
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2025-05-21T14:34:42Z |
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2025 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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NUNES, Sara; Bastos, Rana; MARINHO, Ananda Isis; VIEIRA, Raissa; BENÍCIO, Ingra; NORONHA, Maria Alícia de; LÍRIO, Sofia; BRODSKYN, Cláudia; TAVARES, Natalia Machado. Recent advances in the development and clinical application of miRNAs in infectious diseases. Non-coding RNA Research, v.10, p. 1-14, 2025. |
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https://arca.fiocruz.br/handle/icict/70522 |
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2468-0540 |
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10.1016/j.ncrna.2024.09.005 |
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NUNES, Sara; Bastos, Rana; MARINHO, Ananda Isis; VIEIRA, Raissa; BENÍCIO, Ingra; NORONHA, Maria Alícia de; LÍRIO, Sofia; BRODSKYN, Cláudia; TAVARES, Natalia Machado. Recent advances in the development and clinical application of miRNAs in infectious diseases. Non-coding RNA Research, v.10, p. 1-14, 2025. 2468-0540 10.1016/j.ncrna.2024.09.005 |
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https://arca.fiocruz.br/handle/icict/70522 |
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Elsevier |
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Elsevier |
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