Phylodynamics of HIV-1 subtype C epidemic in east Africa

Bibliographic Details
Main Author: Delatorre, Edson Oliveira
Publication Date: 2012
Other Authors: Bello, Gonzalo
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0041904
Download full: https://arca.fiocruz.br/handle/icict/15811
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Delatorre, Edson OliveiraBello, Gonzalo2016-09-15T14:45:28Z2016-09-15T14:45:28Z2012DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012.1932-6203https://arca.fiocruz.br/handle/icict/1581110.1371/journal.pone.0041904engPublic Library of ScienceInfecções por HIVAfrica OrientalHIV-1 subtipo CHIV-1 subtype CEast AfricaHIV infectionsPhylodynamics of HIV-1 subtype C epidemic in east Africainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The HIV-1 subtype C accounts for an important fraction of HIV infections in east Africa, but little is known about the genetic characteristics and evolutionary history of this epidemic. Here we reconstruct the origin and spatiotemporal dynamics of the major HIV-1 subtype C clades circulating in east Africa. A large number (n = 1,981) of subtype C pol sequences were retrieved from public databases to explore relationships between strains from the east, southern and central African regions. Maximum-likelihood phylogenetic analysis of those sequences revealed that most (>70%) strains from east Africa segregated in a single regional-specific monophyletic group, here called C(EA). A second major Ethiopian subtype C lineage and a large collection of minor Kenyan and Tanzanian subtype C clades of southern African origin were also detected. A bayesian coalescent-based method was then used to reconstruct evolutionary parameters and migration pathways of the C(EA) African lineage. This analysis indicates that the C(EA) clade most probably originated in Burundi around the early 1960s, and later spread to Ethiopia, Kenya, Tanzania and Uganda, giving rise to major country-specific monophyletic sub-clusters between the early 1970s and early 1980s. The results presented here demonstrate that a substantial proportion of subtype C infections in east Africa resulted from dissemination of a single HIV local variant, probably originated in Burundi during the 1960s. Burundi was the most important hub of dissemination of that subtype C clade in east Africa, fueling the origin of new local epidemics in Ethiopia, Kenya, Tanzania and Uganda. 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dc.title.none.fl_str_mv Phylodynamics of HIV-1 subtype C epidemic in east Africa
title Phylodynamics of HIV-1 subtype C epidemic in east Africa
spellingShingle Phylodynamics of HIV-1 subtype C epidemic in east Africa
Delatorre, Edson Oliveira
Infecções por HIV
Africa Oriental
HIV-1 subtipo C
HIV-1 subtype C
East Africa
HIV infections
title_short Phylodynamics of HIV-1 subtype C epidemic in east Africa
title_full Phylodynamics of HIV-1 subtype C epidemic in east Africa
title_fullStr Phylodynamics of HIV-1 subtype C epidemic in east Africa
title_full_unstemmed Phylodynamics of HIV-1 subtype C epidemic in east Africa
title_sort Phylodynamics of HIV-1 subtype C epidemic in east Africa
author Delatorre, Edson Oliveira
author_facet Delatorre, Edson Oliveira
Bello, Gonzalo
author_role author
author2 Bello, Gonzalo
author2_role author
dc.contributor.author.fl_str_mv Delatorre, Edson Oliveira
Bello, Gonzalo
dc.subject.other.none.fl_str_mv Infecções por HIV
Africa Oriental
HIV-1 subtipo C
topic Infecções por HIV
Africa Oriental
HIV-1 subtipo C
HIV-1 subtype C
East Africa
HIV infections
dc.subject.en.none.fl_str_mv HIV-1 subtype C
East Africa
HIV infections
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-15T14:45:28Z
dc.date.available.fl_str_mv 2016-09-15T14:45:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/15811
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0041904
identifier_str_mv DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012.
1932-6203
10.1371/journal.pone.0041904
url https://arca.fiocruz.br/handle/icict/15811
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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