Inflammaging in Endemic Areas for Infectious Diseases

Bibliographic Details
Main Author: Batista, Marina Andrade
Publication Date: 2020
Other Authors: Calvo-Fortes, Fernanda, Silveira-Nunes, Gabriela, Camatta, Giovanna Caliman, Speziali, Elaine, Turroni, Silvia, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Neretti, Nicola, Maioli, Tatiani Uceli, Santos, Rodrigo Ribeiro, Brigidi, Patrizia, Franceschi, Claudio, Faria, Ana Maria Caetano
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3389/fimmu.2020.579972
Download full: https://arca.fiocruz.br/handle/icict/58597
Summary: Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.
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spelling Batista, Marina AndradeCalvo-Fortes, FernandaSilveira-Nunes, GabrielaCamatta, Giovanna CalimanSpeziali, ElaineTurroni, SilviaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisNeretti, NicolaMaioli, Tatiani UceliSantos, Rodrigo RibeiroBrigidi, PatriziaFranceschi, ClaudioFaria, Ana Maria Caetano2023-05-23T19:18:49Z2023-05-23T19:18:49Z2020BATISTA, Marina Andrade et al. Inflammaging in Endemic Areas for Infectious Diseases. Front Immunol., v. 11, 579972, 2020. doi: 10.3389/fimmu.2020.579972.1664-3224https://arca.fiocruz.br/handle/icict/5859710.3389/fimmu.2020.579972engFrontiers Research FoundationInflammaging in Endemic Areas for Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.Universidade Federal de Juiz de Fora. Departamento de Medicina. Governador Valadares, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Departament of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, United States.Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil.Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy.Center for Biophysics, Bioinformatics, Biocomplexity. University of Bologna. Bologna, Italy/Laboratory of Systems Biology of Healthy Aging, Department of Applied Mathematics, Lobachevsky University, Nizhny Novgorod, Russia.Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil.Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts.agingchronic infectiondietary componentsgeneticsinflammaginginflammationmicrobiotainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALInflammaging in Endemic Areas for Infectious Diseases.pdfInflammaging in Endemic Areas for Infectious Diseases.pdfapplication/pdf706038https://arca.fiocruz.br/bitstreams/e14e6bc8-2e57-4c11-96e3-173f6015c2db/downloadba392c07efcbe6770ddb2b45b1c9c78eMD52trueAnonymousREADLICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/58f41ee5-b359-458d-a5cf-5742404bb1ed/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADTEXTInflammaging in Endemic Areas for Infectious Diseases.pdf.txtInflammaging in Endemic Areas for Infectious Diseases.pdf.txtExtracted texttext/plain100481https://arca.fiocruz.br/bitstreams/afa8d1fd-6858-49c5-87d0-bc2e76d13535/download2c83a38298bf2cd7cf139a211b817baeMD55falseAnonymousREADTHUMBNAILInflammaging in Endemic Areas for Infectious Diseases.pdf.jpgInflammaging in Endemic Areas for Infectious Diseases.pdf.jpgGenerated Thumbnailimage/jpeg5097https://arca.fiocruz.br/bitstreams/bfad5d5b-bac5-4c3c-a409-7c067116789b/download9da779179f8e5640d87535eecc7f6d1eMD56falseAnonymousREADicict/585972025-07-30 01:55:07.618open.accessoai:arca.fiocruz.br:icict/58597https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:55:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Inflammaging in Endemic Areas for Infectious Diseases
title Inflammaging in Endemic Areas for Infectious Diseases
spellingShingle Inflammaging in Endemic Areas for Infectious Diseases
Batista, Marina Andrade
aging
chronic infection
dietary components
genetics
inflammaging
inflammation
microbiota
title_short Inflammaging in Endemic Areas for Infectious Diseases
title_full Inflammaging in Endemic Areas for Infectious Diseases
title_fullStr Inflammaging in Endemic Areas for Infectious Diseases
title_full_unstemmed Inflammaging in Endemic Areas for Infectious Diseases
title_sort Inflammaging in Endemic Areas for Infectious Diseases
author Batista, Marina Andrade
author_facet Batista, Marina Andrade
Calvo-Fortes, Fernanda
Silveira-Nunes, Gabriela
Camatta, Giovanna Caliman
Speziali, Elaine
Turroni, Silvia
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Neretti, Nicola
Maioli, Tatiani Uceli
Santos, Rodrigo Ribeiro
Brigidi, Patrizia
Franceschi, Claudio
Faria, Ana Maria Caetano
author_role author
author2 Calvo-Fortes, Fernanda
Silveira-Nunes, Gabriela
Camatta, Giovanna Caliman
Speziali, Elaine
Turroni, Silvia
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Neretti, Nicola
Maioli, Tatiani Uceli
Santos, Rodrigo Ribeiro
Brigidi, Patrizia
Franceschi, Claudio
Faria, Ana Maria Caetano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Batista, Marina Andrade
Calvo-Fortes, Fernanda
Silveira-Nunes, Gabriela
Camatta, Giovanna Caliman
Speziali, Elaine
Turroni, Silvia
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Neretti, Nicola
Maioli, Tatiani Uceli
Santos, Rodrigo Ribeiro
Brigidi, Patrizia
Franceschi, Claudio
Faria, Ana Maria Caetano
dc.subject.en.none.fl_str_mv aging
chronic infection
dietary components
genetics
inflammaging
inflammation
microbiota
topic aging
chronic infection
dietary components
genetics
inflammaging
inflammation
microbiota
description Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-05-23T19:18:49Z
dc.date.available.fl_str_mv 2023-05-23T19:18:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BATISTA, Marina Andrade et al. Inflammaging in Endemic Areas for Infectious Diseases. Front Immunol., v. 11, 579972, 2020. doi: 10.3389/fimmu.2020.579972.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/58597
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2020.579972
identifier_str_mv BATISTA, Marina Andrade et al. Inflammaging in Endemic Areas for Infectious Diseases. Front Immunol., v. 11, 579972, 2020. doi: 10.3389/fimmu.2020.579972.
1664-3224
10.3389/fimmu.2020.579972
url https://arca.fiocruz.br/handle/icict/58597
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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