Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity

Bibliographic Details
Main Author: Bongertz, V.
Publication Date: 2001
Other Authors: Costa, C. I., Veloso, V. G., Grinsztejn, Beatriz, João Filho, E. C., Calvet, G., Pilotto, J. H., Guimarães, M. L., Morgado, M. G.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1046/j.1365-3083.2001.00866.x
Download full: https://arca.fiocruz.br/handle/icict/31353
Summary: Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.
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spelling Bongertz, V.Costa, C. I.Veloso, V. G.Grinsztejn, BeatrizJoão Filho, E. C.Calvet, G.Pilotto, J. H.Guimarães, M. L.Morgado, M. G.2019-01-30T10:39:22Z2019-01-30T10:39:22Z2001BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001.0300-9475https://arca.fiocruz.br/handle/icict/3135310.1046/j.1365-3083.2001.00866.xengVertical HIV-1 transmission: importance of neutralizing antibody titer and specificityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas Hospital Research Center. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas Hospital Research Center. Rio de Janeiro, RJ, Brazil.Servidores do Estado Hospital. Rio de Janeiro, RJ, Brazil.Servidores do Estado Hospital. Rio de Janeiro, RJ, Brazil.Nova Iguaçu General Hospital. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.Neutralization analyses were carried out with plasma from 132 volunteer human immunodeficiency virus (HIV)-1 infected women (76% pregnant, 24% with infants suspected for HIV-1 infection) collected between 1994 and 1998, against autologous and heterologous primary- and the reference HIV-1 MN isolates. A significantly lower percentage of HIV-1 transmissions was observed after 1996, parallel to a more intense antiretroviral treatment of infected pregnant women. HIV-1 isolation was significantly more frequent from peripheral blood mononuclear cells of mothers of infected children than mothers of uninfected children (P = 0.0065). Neutralization of autologous HIV-1 isolates was comparable for HIV-1 transmitters and nontransmitters' plasma, whereas neutralization of the reference isolate HIV-1 MN was more frequent at high titers for pregnant women who did not transmit HIV to their offspring compared to pregnant women who did. Although neutralization of heterologous primary HIV-1 isolates from HIV transmitters and non transmitters by transmitter plasma occurred with similar frequency, neutralization of isolates from transmitters was much more frequent when heterologous plasma from nontransmitters were used. Macrophage-tropic heterologous HIV-1 isolates were neutralized more frequently at higher titers by plasma from nontransmitters than from transmitters. The results obtained indicate that antiretroviral treatment, lack of success of HIV-1 isolation and high titers of antibodies able to neutralize macrophage-tropic viruses appear to be of importance for protection against HIV-1 vertical transmission for the group of patients studied.Vertical HIV-1 transmissionHIVEpidemicNeutralizing antibody03 Saúde e Bem-Estarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://arca.fiocruz.br/bitstreams/11b8acee-2d4d-4bf4-8f93-7d8511d8a633/download586c046dcfeef936e32f0323bb9a47c0MD51falseAnonymousREADORIGINALve_Bongertz_V_etal_INI_2001.pdfve_Bongertz_V_etal_INI_2001.pdfapplication/pdf181928https://arca.fiocruz.br/bitstreams/62334f96-299a-4f45-a4a3-44d4b815db6b/download72445e7c85da9ed3d5063b257b2665f5MD52trueAnonymousREADTEXTve_Bongertz_V_etal_INI_2001.pdf.txtve_Bongertz_V_etal_INI_2001.pdf.txtExtracted texttext/plain42984https://arca.fiocruz.br/bitstreams/86314868-c55a-4203-bacc-817df34fcc75/downloadf360bc1bea145a2684086b5cf2c8a903MD57falseAnonymousREADTHUMBNAILve_Bongertz_V_etal_INI_2001.pdf.jpgve_Bongertz_V_etal_INI_2001.pdf.jpgGenerated Thumbnailimage/jpeg5573https://arca.fiocruz.br/bitstreams/ddc9b8b2-3387-4bbb-8525-c6a9f0c86531/downloadde73dd00329a6fbfe51694b11dc4c974MD58falseAnonymousREADicict/313532025-07-29 18:24:17.405open.accessoai:arca.fiocruz.br:icict/31353https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T21:24:17Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
title Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
spellingShingle Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
Bongertz, V.
Vertical HIV-1 transmission
HIV
Epidemic
Neutralizing antibody
03 Saúde e Bem-Estar
title_short Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
title_full Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
title_fullStr Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
title_full_unstemmed Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
title_sort Vertical HIV-1 transmission: importance of neutralizing antibody titer and specificity
author Bongertz, V.
author_facet Bongertz, V.
Costa, C. I.
Veloso, V. G.
Grinsztejn, Beatriz
João Filho, E. C.
Calvet, G.
Pilotto, J. H.
Guimarães, M. L.
Morgado, M. G.
author_role author
author2 Costa, C. I.
Veloso, V. G.
Grinsztejn, Beatriz
João Filho, E. C.
Calvet, G.
Pilotto, J. H.
Guimarães, M. L.
Morgado, M. G.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bongertz, V.
Costa, C. I.
Veloso, V. G.
Grinsztejn, Beatriz
João Filho, E. C.
Calvet, G.
Pilotto, J. H.
Guimarães, M. L.
Morgado, M. G.
dc.subject.en.none.fl_str_mv Vertical HIV-1 transmission
HIV
Epidemic
Neutralizing antibody
topic Vertical HIV-1 transmission
HIV
Epidemic
Neutralizing antibody
03 Saúde e Bem-Estar
dc.subject.ods.none.fl_str_mv 03 Saúde e Bem-Estar
description Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Department of Immunology. AIDS & Molecular Immunology Laboratory. Rio de Janeiro, RJ, Brazil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2019-01-30T10:39:22Z
dc.date.available.fl_str_mv 2019-01-30T10:39:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/31353
dc.identifier.issn.none.fl_str_mv 0300-9475
dc.identifier.doi.none.fl_str_mv 10.1046/j.1365-3083.2001.00866.x
identifier_str_mv BONGERTZ, V. et al. Vertical HIV-1 Transmission: Importance of neutralizing antibody titer and specificity. Scandinavian Journal of Immunology, v. 53, p. 302-309, 2001.
0300-9475
10.1046/j.1365-3083.2001.00866.x
url https://arca.fiocruz.br/handle/icict/31353
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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