Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
| Main Author: | |
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| Publication Date: | 2009 |
| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://arca.fiocruz.br/handle/icict/20592 |
Summary: | FAPESB (Fundação de Amparo a Pesquisa do Estado da Bahia), PRONEX - CNPq |
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Andrade, Antônio Ricardo deCotrim, Helma PinchemelAlves, ErivaldoSoares, DanielaRocha, RaquelAlmeida, Alessandro de MouraAlmeida, Carolina de GodoyFreitas, Luiz Antonio Rodrigues de2017-08-11T17:11:12Z2017-08-11T17:11:12Z2009ANDRADE, A. R. et al. Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery. Annals of Hepatology, v. 7, n. 4, p. 364-368, 2008.0939-5555https://arca.fiocruz.br/handle/icict/20592FAPESB (Fundação de Amparo a Pesquisa do Estado da Bahia), PRONEX - CNPqUniversidade Federal da Bahia. Postgraduate Course in Medicine and Health. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Salvador, BA, BrasilCenter for the Surgical Treatment of Obesity. Surgeon. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Programa de Pós Graduação em Medicina e Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasilassociated with NAFLD, and bariatric surgery (BAS) is traditionally indicated for the treatment of severely obese individuals. Here, we discuss the behavior and prognosis of this liver disease following post-surgical weight loss. Aim: To evaluate the influence of the BAS on the clinical and biochemical parameters of NAFLD in severely obese patients. Methodology: An intervention study included obese individuals (BMI≥ 35kg/m2), who had been submitted to liver biopsy during BAS and had NAFLD. HAIR (hypertension, ALT and insulin resistance and BAAT (BMI, ALT, age and triglycerides) scores and FLI (Fatty Liver Index) were used to compare the patients at the time of surgery, and 12-30 months following weight loss. Results: From October 2004 to September 2007, 122 patients were diagnosed with NAFLD, 40 of whom agreed to participate in the study. The mean age was 37.7 ± 12.5 years, 60% were women and 80% had steatohepatitis (NASH) with fibrosis upon analysis of the liver biopsy performed during BAS. Mean weight loss was 46.0 ± 2.0 kg. After 21 ± 5.8 months of follow-up, a significant improvement was found in all the variables analyzed (79.3% according to the HAIR scores, 95.2% as measured by the BAAT score and 72.5% by the FLI. Conclusion: The results suggest that treatment of obesity by bariatric surgery may influence the prognosis of NAFLD. In addition to weight loss, we observed improvement in the clinical and biochemical parameters related to NAFLD, such as anthropometrics index, hypertension, aminotransferases, triglycerides and insulin resistance.engSpringer VerlagEsteato-hepatite não alcoólicaObesidade mórbidaSíndrome X metabólicaResistência à insulinaObesidadeNonalcoholic steatohepatitis (NASH)Morbid obesityMetabolic syndromeInsulin resistanceObesityNonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgeryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/0d430419-40db-44aa-ba4f-b3b54c4e9b38/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALAndrade AR Nonalcoholic fatty liver....pdfAndrade AR Nonalcoholic fatty liver....pdfapplication/pdf201925https://arca.fiocruz.br/bitstreams/4e19f351-5d57-4106-b382-bbfd6911a48c/download5453fe869ff0d42e8e05a230dc301598MD52trueAnonymousREADTEXTAndrade AR Nonalcoholic fatty liver....pdf.txtAndrade AR Nonalcoholic fatty liver....pdf.txtExtracted texttext/plain31179https://arca.fiocruz.br/bitstreams/e488eb11-2ce6-4281-9d44-325cdd9b484a/download6c50e1b14d16896b2894d5f5c8441638MD55falseAnonymousREADTHUMBNAILAndrade AR Nonalcoholic fatty liver....pdf.jpgAndrade AR Nonalcoholic fatty liver....pdf.jpgGenerated Thumbnailimage/jpeg4110https://arca.fiocruz.br/bitstreams/7587d8ef-ccaf-4436-9116-a12ae203062e/download0f3ee22260346e6a39a537e4393e5bacMD56falseAnonymousREADicict/205922025-07-30 01:48:11.384open.accessoai:arca.fiocruz.br:icict/20592https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:48:11Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| title |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| spellingShingle |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery Andrade, Antônio Ricardo de Esteato-hepatite não alcoólica Obesidade mórbida Síndrome X metabólica Resistência à insulina Obesidade Nonalcoholic steatohepatitis (NASH) Morbid obesity Metabolic syndrome Insulin resistance Obesity |
| title_short |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| title_full |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| title_fullStr |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| title_full_unstemmed |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| title_sort |
Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery |
| author |
Andrade, Antônio Ricardo de |
| author_facet |
Andrade, Antônio Ricardo de Cotrim, Helma Pinchemel Alves, Erivaldo Soares, Daniela Rocha, Raquel Almeida, Alessandro de Moura Almeida, Carolina de Godoy Freitas, Luiz Antonio Rodrigues de |
| author_role |
author |
| author2 |
Cotrim, Helma Pinchemel Alves, Erivaldo Soares, Daniela Rocha, Raquel Almeida, Alessandro de Moura Almeida, Carolina de Godoy Freitas, Luiz Antonio Rodrigues de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Antônio Ricardo de Cotrim, Helma Pinchemel Alves, Erivaldo Soares, Daniela Rocha, Raquel Almeida, Alessandro de Moura Almeida, Carolina de Godoy Freitas, Luiz Antonio Rodrigues de |
| dc.subject.other.none.fl_str_mv |
Esteato-hepatite não alcoólica Obesidade mórbida Síndrome X metabólica Resistência à insulina Obesidade |
| topic |
Esteato-hepatite não alcoólica Obesidade mórbida Síndrome X metabólica Resistência à insulina Obesidade Nonalcoholic steatohepatitis (NASH) Morbid obesity Metabolic syndrome Insulin resistance Obesity |
| dc.subject.en.none.fl_str_mv |
Nonalcoholic steatohepatitis (NASH) Morbid obesity Metabolic syndrome Insulin resistance Obesity |
| description |
FAPESB (Fundação de Amparo a Pesquisa do Estado da Bahia), PRONEX - CNPq |
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2009 |
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2009 |
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2017-08-11T17:11:12Z |
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2017-08-11T17:11:12Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ANDRADE, A. R. et al. Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery. Annals of Hepatology, v. 7, n. 4, p. 364-368, 2008. |
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https://arca.fiocruz.br/handle/icict/20592 |
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0939-5555 |
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ANDRADE, A. R. et al. Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery. Annals of Hepatology, v. 7, n. 4, p. 364-368, 2008. 0939-5555 |
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Springer Verlag |
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Springer Verlag |
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