Human_leishmaniasis/cytokines.bahia.br

Bibliographic Details
Main Author: Barral Netto, Manoel
Publication Date: 1998
Other Authors: Brodskyn, Claudia Ida, Carvalho Filho, Edgar Marcelino, Barral, Aldina Maria Prado
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://arca.fiocruz.br/handle/icict/5670
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Barral Netto, ManoelBrodskyn, Claudia IdaCarvalho Filho, Edgar MarcelinoBarral, Aldina Maria Prado2012-10-15T21:08:03Z2012-10-15T21:08:03Z1998BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998.0100-879Xhttps://arca.fiocruz.br/handle/icict/5670engHuman_leishmaniasis/cytokines.bahia.brinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-gamma is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-gamma, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-gamma opposing cytokine, and IL-12 as an IFN-gamma inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-gamma production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-gamma production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4.CytokinesHuman leishmaniasisImmunoregulationIL-12IL-10Citocinas/fisiologiaLeishmaniose/imunologiaBrasilHumanosInterleucina-10Interleucina-12info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarral-Netto M Human leishmaniasis....pdfBarral-Netto M Human leishmaniasis....pdfapplication/pdf298111https://arca.fiocruz.br/bitstreams/4dd886ba-6504-4599-8a86-f33db5bd8213/download0a9eee5a6728b4cde44d807f53c00203MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://arca.fiocruz.br/bitstreams/3c241721-1813-4523-a228-4c74f6244fb3/download06db3f0df647fd9ddff657403bbe0ee2MD52falseAnonymousREADTEXTBarral-Netto M Human leishmaniasis....pdf.txtBarral-Netto M Human leishmaniasis....pdf.txtExtracted texttext/plain30606https://arca.fiocruz.br/bitstreams/97dbb5b1-7709-440a-a3d6-cc4c20c6c62a/download6f0929b9cab404b878018f8c12b8b534MD56falseAnonymousREADTHUMBNAILBarral-Netto M Human leishmaniasis....pdf.jpgBarral-Netto M Human leishmaniasis....pdf.jpgGenerated Thumbnailimage/jpeg5046https://arca.fiocruz.br/bitstreams/ffec8960-3a37-4328-888a-ab2c795b7f9f/downloadccbb3555f4dfd5c5885fc3657620c50eMD57falseAnonymousREADicict/56702025-07-29 20:43:45.906open.accessoai:arca.fiocruz.br:icict/5670https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T23:43:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Human_leishmaniasis/cytokines.bahia.br
title Human_leishmaniasis/cytokines.bahia.br
spellingShingle Human_leishmaniasis/cytokines.bahia.br
Barral Netto, Manoel
Cytokines
Human leishmaniasis
Immunoregulation
IL-12
IL-10
Citocinas/fisiologia
Leishmaniose/imunologia
Brasil
Humanos
Interleucina-10
Interleucina-12
title_short Human_leishmaniasis/cytokines.bahia.br
title_full Human_leishmaniasis/cytokines.bahia.br
title_fullStr Human_leishmaniasis/cytokines.bahia.br
title_full_unstemmed Human_leishmaniasis/cytokines.bahia.br
title_sort Human_leishmaniasis/cytokines.bahia.br
author Barral Netto, Manoel
author_facet Barral Netto, Manoel
Brodskyn, Claudia Ida
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
author_role author
author2 Brodskyn, Claudia Ida
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
author2_role author
author
author
dc.contributor.author.fl_str_mv Barral Netto, Manoel
Brodskyn, Claudia Ida
Carvalho Filho, Edgar Marcelino
Barral, Aldina Maria Prado
dc.subject.en.none.fl_str_mv Cytokines
Human leishmaniasis
Immunoregulation
IL-12
IL-10
topic Cytokines
Human leishmaniasis
Immunoregulation
IL-12
IL-10
Citocinas/fisiologia
Leishmaniose/imunologia
Brasil
Humanos
Interleucina-10
Interleucina-12
dc.subject.decs.none.fl_str_mv Citocinas/fisiologia
Leishmaniose/imunologia
Brasil
Humanos
Interleucina-10
Interleucina-12
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2012-10-15T21:08:03Z
dc.date.available.fl_str_mv 2012-10-15T21:08:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/5670
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv BARRAL-NETTO, M. et al. Human_leishmaniasis/cytokines.bahia.br. Brazilian Journal of Medical Biological Research, v. 31, n. 1, p. 149-55, jan. 1998.
0100-879X
url https://arca.fiocruz.br/handle/icict/5670
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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