Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections
| Main Author: | |
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| Publication Date: | 2020 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://arca.fiocruz.br/handle/icict/43316 |
Summary: | Intramural Research Program from Hospital da Cidade and from the Fundação Oswaldo Cruz. The work of B.B.A. was supported by the the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior scientist fellowship). KFF received a fellowship from the Programa Nacional de Pós-Doutorado, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, finance code 001). MBA and TAC received research fellowships from Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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Otero, Matheus L.Menezes, Rodrigo C.Ferreira, Isabella B. B.Issa, Francine L.Agareno, GabrielCarmo, Thomas AzevedoArriaga Gutiérrez, María BelenFukutani, Kiyoshi FerreiraPamplona Neto, LicurgoAgareno, SydneyFilgueiras Filho, Nivaldo M.Akarami, Kevan M.Andrade, Bruno de Bezerril2020-09-11T11:52:30Z2020-09-11T11:52:30Z2020OTERO, Matheus L. et al. Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections. Infection and Drug Resistance, 2020.1178-6973https://arca.fiocruz.br/handle/icict/43316Intramural Research Program from Hospital da Cidade and from the Fundação Oswaldo Cruz. The work of B.B.A. was supported by the the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior scientist fellowship). KFF received a fellowship from the Programa Nacional de Pós-Doutorado, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, finance code 001). MBA and TAC received research fellowships from Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.União Metropolitana para o Desenvolvimento da Educação e Cultura. Curso de Medicina. Salvador, BA, Brasil.Universidade do Estado da Bahia. Salvador, BA, Brasil.Universidade do Estado da Bahia. Curso de Medicina. Salvador, BA, Brasil.Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil.Universidade do Estado da Bahia. Curso de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Hospital da Cidade. Intensive Care Unit. Salvador, BA, Brazil.Hospital da Cidade. Intensive Care Unit. Salvador, BA, Brazil.Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Universidade do Estado da Bahia. Salvador, BA, Brasil / Hospital da Cidade. Intensive Care Unit. Salvador, BA, Brazil.University of California. Division of Infectious Diseases and Pulmonary Critical Care and Sleep Medicine. Department of Medicine. San Diego, California, USA.Universidade Salvador. Laureate Universities. Curso de Medicina. Salvador, BA, Brasil / Universidade do Estado da Bahia. Curso de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Evaluate host and pathogen factors associated with mortality in those with hospital acquired infections (HAI) in a tertiary intensive care unit in Brazil. Methods: Observational and analytical cohort single center study in a general intensive care unit (ICU) in Northeastern Brazil between January 2016 and August 2018, including those over 18 years of age admitted to the ICU found to have a HAI. Results: A total of 165 patients were included, with a mean age of 72 years and male predominance (53.3%) and observed mortality of 46%. Mortality in those with HAI was significantly associated with older age, increased ICU length of stay and readmission to the ICU in univariate analysis. Multivariate analysis revealed that development of septic shock and obtundation during ICU admission was significantly associated with an increased risk of death (OR: 6.94, 95% CI 1.23–39.27, OR: 2.48, 95% CI 1.17–5.29, respectively). A trend towards mortality risk was noted in those with increased age and prior cardiovascular disease. Surprisingly, mortality risk was independent of site of infection, type of pathogen and antibiotic resistance. Furthermore, having more than one HAI over the course of the ICU admission did not impact mortality. Conclusion: Risk of death in those with HAI is associated with obtundation and septic shock, in addition to vasopressor use. Host factors, rather than pathogen-specific characteristics or infecting site, impact risk of death related to HAI in the ICU.engDove Medical PressInfecção hospitalar adquiridaUTIMortalidadeDoença críticaChoque sépticoTratamento intensivoHospital acquired infectionICUMortalityCritical illnessSeptic shockIntensive care03 Saúde e Bem-EstarFactors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/286c3624-b3fa-48f5-92f0-a19365749fb5/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALOtero Matheus L Factors....pdfOtero Matheus L Factors....pdfapplication/pdf835409https://arca.fiocruz.br/bitstreams/79819546-c1a2-4501-89a0-fbaf928cba1e/download4e3586ebdd9babe4118b7763596aeecaMD52trueAnonymousREADTEXTOtero Matheus L Factors....pdf.txtOtero Matheus L Factors....pdf.txtExtracted texttext/plain38752https://arca.fiocruz.br/bitstreams/c7b7eb35-5eec-4fae-b0fb-ef70a2526058/download6bf5222bb6c01640bebf9b503b77bffbMD55falseAnonymousREADTHUMBNAILOtero Matheus L Factors....pdf.jpgOtero Matheus L Factors....pdf.jpgGenerated Thumbnailimage/jpeg6381https://arca.fiocruz.br/bitstreams/ae230da7-d5d7-4e56-a943-544e73ec53ff/downloadf913e10926d264aab586553630229dfaMD56falseAnonymousREADicict/433162025-07-29 22:52:22.303open.accessoai:arca.fiocruz.br:icict/43316https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T01:52:22Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| title |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| spellingShingle |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections Otero, Matheus L. Infecção hospitalar adquirida UTI Mortalidade Doença crítica Choque séptico Tratamento intensivo Hospital acquired infection ICU Mortality Critical illness Septic shock Intensive care 03 Saúde e Bem-Estar |
| title_short |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| title_full |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| title_fullStr |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| title_full_unstemmed |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| title_sort |
Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections |
| author |
Otero, Matheus L. |
| author_facet |
Otero, Matheus L. Menezes, Rodrigo C. Ferreira, Isabella B. B. Issa, Francine L. Agareno, Gabriel Carmo, Thomas Azevedo Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo M. Akarami, Kevan M. Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Menezes, Rodrigo C. Ferreira, Isabella B. B. Issa, Francine L. Agareno, Gabriel Carmo, Thomas Azevedo Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo M. Akarami, Kevan M. Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Otero, Matheus L. Menezes, Rodrigo C. Ferreira, Isabella B. B. Issa, Francine L. Agareno, Gabriel Carmo, Thomas Azevedo Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo M. Akarami, Kevan M. Andrade, Bruno de Bezerril |
| dc.subject.other.none.fl_str_mv |
Infecção hospitalar adquirida UTI Mortalidade Doença crítica Choque séptico Tratamento intensivo |
| topic |
Infecção hospitalar adquirida UTI Mortalidade Doença crítica Choque séptico Tratamento intensivo Hospital acquired infection ICU Mortality Critical illness Septic shock Intensive care 03 Saúde e Bem-Estar |
| dc.subject.en.none.fl_str_mv |
Hospital acquired infection ICU Mortality Critical illness Septic shock Intensive care |
| dc.subject.ods.none.fl_str_mv |
03 Saúde e Bem-Estar |
| description |
Intramural Research Program from Hospital da Cidade and from the Fundação Oswaldo Cruz. The work of B.B.A. was supported by the the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; senior scientist fellowship). KFF received a fellowship from the Programa Nacional de Pós-Doutorado, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, finance code 001). MBA and TAC received research fellowships from Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). |
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2020 |
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2020-09-11T11:52:30Z |
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2020-09-11T11:52:30Z |
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2020 |
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info:eu-repo/semantics/article |
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OTERO, Matheus L. et al. Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections. Infection and Drug Resistance, 2020. |
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https://arca.fiocruz.br/handle/icict/43316 |
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1178-6973 |
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OTERO, Matheus L. et al. Factors Associated with Mortality in Critically Ill Patients Diagnosed with Hospital Acquired Infections. Infection and Drug Resistance, 2020. 1178-6973 |
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Dove Medical Press |
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Dove Medical Press |
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