In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS

Bibliographic Details
Main Author: Castro, Aline Pereira
Publication Date: 2018
Other Authors: Kawano, Taila, Spelta, Lidia Emmanuela Wiazowski, Castro, Andreísa Teixeira de, Pereira, Neusa Araújo, Couto, Flávia Fernanda Bubula, Santos, Marcelo Henrique dos, Boralli, Vanessa Bergamin, Marques, Marcos José
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.phymed.2017.11.001
Download full: https://arca.fiocruz.br/handle/icict/28591
Summary: Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. Laboratório de Parasitologia. Alfenas, MG, Brazil.
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spelling Castro, Aline PereiraKawano, TailaSpelta, Lidia Emmanuela WiazowskiCastro, Andreísa Teixeira dePereira, Neusa AraújoCouto, Flávia Fernanda BubulaSantos, Marcelo Henrique dosBoralli, Vanessa BergaminMarques, Marcos José2018-09-06T16:33:30Z2018-09-06T16:33:30Z2018CASTRO, Aline Pereira et al. In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS. Phytomedicine, v. 38, p. 66-73, Jan. 2018.0944-7113https://arca.fiocruz.br/handle/icict/2859110.1016/j.phymed.2017.11.001engElsevier7-epiclusianoneRatoFarmacocinéticaSchistosomaUPLC-MS/MS7-epiclusianoneMicePharmacokineticsSchistosomiasisUPLC-MS/MSIn vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Alfenas. Instituto de Ciências Biomédicas. Laboratório de Parasitologia. Alfenas, MG, Brazil.Universidade Federal de Alfenas. Departamento de Análises Clínicas e Toxicológicas. Alfenas, MG, Brazil.Universidade Federal de Alfenas. Departamento de Análises Clínicas e Toxicológicas. Alfenas, MG, Brazil.Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. Laboratório de Parasitologia. Alfenas, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Viçosa. Departamento de Química. Viçosa, MG, Brazil.Universidade Federal de Alfenas. Departamento de Análises Clínicas e Toxicológicas. Alfenas, MG, Brazil.Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. Laboratório de Parasitologia. Alfenas, MG, Brazil.Background: The tetraprenylated benzophenone 7-epiclusianone (7-epi) is a substance isolated from the fruits of Garcinia brasiliensis and in vitro studies have demonstrated that 7-epi is effective against Schistosoma mansoni adult worms. Hypothesis/Purpose: Here we report the in vivo evaluation of 7-epi and its pharmacokinetic in healthy and Schistosoma mansoni infected mice. Study design and methods: In this work, we assayed the schistosomicidal activity of 7-epi at the dose of 100 mg/kg and 300 mg/kg body weight/day in S. mansoni experimentally infected mice. Besides, two groups of animals were treated and a detailed analysis of plasma samples was performed by liquid chromatography coupled to mass spectrometry (LC-MS/MS). Results: The worm burden showed a reduction in the infected mice after treatment with 300 mg/kg for five days (p < .05). And we found an increase of AUC0–∞ (20846 vs. 32438 ng.h/ml) and a decrease of total apparent clearance (0.006 vs. 0.004 l/h/kg) of 7- epi in the infected group compared to the healthy group. Consequently, the half-life increased (1.73 vs. 6.11 h) and Cmax was reduced (5427.5 vs. 3321.0 ng/ml) in the infected group compared to the healthy group. In addition, histopathological investigations were performed analysing liver samples from healthy and infected mice. Conclusion: The results showed significant schistosomicidal in vivo activity at 300 mg/kg. In addition, livers from S. mansoni infected mice showed a greater number of egg granulomas and the changes in the pharmacokinetic parameters in this group could be associated with the pathology of the murine experimental schistosomiasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://arca.fiocruz.br/bitstreams/368454f5-659f-42e8-b07c-9ce651c7b036/download9193a7c197bc67acd023525e72a03240MD51falseAnonymousREADORIGINALIn vivo schistosomicidal activity of 7-epiclusianone.pdfIn vivo schistosomicidal activity of 7-epiclusianone.pdfapplication/pdf6122890https://arca.fiocruz.br/bitstreams/d67dc825-97ac-49ca-bb3e-e0eea54ef87f/downloadfce289c8db45d3749d431c11916e0187MD52trueAnonymousREADTEXTIn vivo schistosomicidal activity of 7-epiclusianone.pdf.txtIn vivo schistosomicidal activity of 7-epiclusianone.pdf.txtExtracted texttext/plain364https://arca.fiocruz.br/bitstreams/dd5cff70-18d8-438f-91fd-0c8fbb1f71c2/downloadd3df0b31aadb8ce645443c8b8f0b7254MD57falseAnonymousREADTHUMBNAILIn vivo schistosomicidal activity of 7-epiclusianone.pdf.jpgIn vivo schistosomicidal activity of 7-epiclusianone.pdf.jpgGenerated Thumbnailimage/jpeg5128https://arca.fiocruz.br/bitstreams/80f8567a-7bbe-4c71-9753-8321fb1b2e5b/downloadbeb997224ee23fca3df956e47b6c52b9MD58falseAnonymousREADicict/285912025-07-29 20:23:00.902open.accessoai:arca.fiocruz.br:icict/28591https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T23:23Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
title In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
spellingShingle In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
Castro, Aline Pereira
7-epiclusianone
Rato
Farmacocinética
Schistosoma
UPLC-MS/MS
7-epiclusianone
Mice
Pharmacokinetics
Schistosomiasis
UPLC-MS/MS
title_short In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
title_full In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
title_fullStr In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
title_full_unstemmed In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
title_sort In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS
author Castro, Aline Pereira
author_facet Castro, Aline Pereira
Kawano, Taila
Spelta, Lidia Emmanuela Wiazowski
Castro, Andreísa Teixeira de
Pereira, Neusa Araújo
Couto, Flávia Fernanda Bubula
Santos, Marcelo Henrique dos
Boralli, Vanessa Bergamin
Marques, Marcos José
author_role author
author2 Kawano, Taila
Spelta, Lidia Emmanuela Wiazowski
Castro, Andreísa Teixeira de
Pereira, Neusa Araújo
Couto, Flávia Fernanda Bubula
Santos, Marcelo Henrique dos
Boralli, Vanessa Bergamin
Marques, Marcos José
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Aline Pereira
Kawano, Taila
Spelta, Lidia Emmanuela Wiazowski
Castro, Andreísa Teixeira de
Pereira, Neusa Araújo
Couto, Flávia Fernanda Bubula
Santos, Marcelo Henrique dos
Boralli, Vanessa Bergamin
Marques, Marcos José
dc.subject.other.none.fl_str_mv 7-epiclusianone
Rato
Farmacocinética
Schistosoma
UPLC-MS/MS
topic 7-epiclusianone
Rato
Farmacocinética
Schistosoma
UPLC-MS/MS
7-epiclusianone
Mice
Pharmacokinetics
Schistosomiasis
UPLC-MS/MS
dc.subject.en.none.fl_str_mv 7-epiclusianone
Mice
Pharmacokinetics
Schistosomiasis
UPLC-MS/MS
description Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. Laboratório de Parasitologia. Alfenas, MG, Brazil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-06T16:33:30Z
dc.date.available.fl_str_mv 2018-09-06T16:33:30Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Aline Pereira et al. In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS. Phytomedicine, v. 38, p. 66-73, Jan. 2018.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/28591
dc.identifier.issn.none.fl_str_mv 0944-7113
dc.identifier.doi.none.fl_str_mv 10.1016/j.phymed.2017.11.001
identifier_str_mv CASTRO, Aline Pereira et al. In vivo schistosomicidal activity of 7-epiclusianone and its quantification in the plasma of healthy and Schistosoma mansoni infected mice using UPLC-MS/MS. Phytomedicine, v. 38, p. 66-73, Jan. 2018.
0944-7113
10.1016/j.phymed.2017.11.001
url https://arca.fiocruz.br/handle/icict/28591
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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