Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Conference object |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://arca.fiocruz.br/handle/icict/64513 |
Summary: | Fundação Oswaldo Cruz (FIOCRUZ), Instituto Gonçalo Moniz (IGM). |
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Vasconcelos, Géssica AlmeidaCosta, Bernardo GrativalFaria, Carolina Dourado deSchramm Neto, Fernando Antônio RamosMachado, Yuri de JesusCasaes, Ane CarolineOliveira, Marcos Vinicius Lima deFialho, Thainá Rodrigues de SouzaSantos, Ronald Alves dosSantos, Keila Ramos dosOliveira, Bruna Souza S.Oliveira, Ricardo RiccioSiqueira, Isadora Cristina de2024-06-17T14:30:43Z2024-06-17T14:30:43Z2022VASCONCELOS, Géssica Almeida et al. Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment. In: SIMPÓSIO INTERNACIONAL SOBRE ESQUISTOSSOMOSE, 16, 2022, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: Fiocruz, 21 a 23 de novembro de 2022. p.1.https://arca.fiocruz.br/handle/icict/64513Fundação Oswaldo Cruz (FIOCRUZ), Instituto Gonçalo Moniz (IGM).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.BACKGROUND: Praziquantel (PZQ) is the recommended treatment for managing human Schistosomiasis. This drug commonly causes transient adverse effects such as headache, dizziness, nausea, diarrhea, and abdominal pain. Hypersensitive reactions are rare, with only 7 cases have been reported worldwide. A 13-year-old Brazilian female suffered anaphylaxis after taking PZQ to treat Schistosomiasis mansoni, the first case reported in Brazil. CASE DESCRIPTION: The patient was a 13-year-old-female from Conde, Bahia, Brazil. She was screened by an infectious disease doctor, and the intake of 60mg/Kg PZQ was indicated. Previous hypersensitivity to the medication was denied. However, about an hour later, the patient reported rash and generalized edema, evolving into dizziness and somnolence. Fexofenadine (120mg) was administered, and she was taken to the local family health unit. At arrival, the patient presented with tachycardia (131 bpm), dyspnea (27 BPM), somnolence, and worsening saturation (90%), and 20mg prednisone were administered. Forty minutes after, the patient evolved with sudoresis and hypotension, and 0.6ml (0.01mg/kg) of epinephrine was administered intramuscularly. The patient was transferred to a hospital, and upon arrival, she presented hypotension, sudoresis, and altered mental status. She received venous access, and oxygenation and evolved with a good prognosis, being discharged the next day. DISCUSSION: The present case demonstrated symptoms compatible with anaphylaxis, such as skin rash, dyspnea, tachycardia, worsening saturation, and generalized edema, an hour after PZQ ingestion. This drug can sometimes cause hypersensitivity reactions induced by a sudden antigen released from hatched schistosome eggs and dying worms. However, since PZQ's TMax is 2 hours, that would be a much later response compared to this case. The immediate post-ingestion response suggests that it was due to drug allergy. CONCLUSION: Although hypersensitivity reactions to PZQ are rare, they can be associated with severe symptoms and outcomes. Therefore, health professionals should be aware of this lifethreatening adverse effect.engFIOCRUZReação anafiláticaPraziquantelEsquistossomoseTratamentoAnaphylactic reactionPraziquantelSchistosomiasisTreatmentAnafilaxiaPraziquantelEsquistossomoseTerapêuticaCase report: anaphylactic reaction to praziquantel during schistosomiasis treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/66107a5c-303b-4818-957e-ba535805518b/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALVasconcelo, Géssica Almeida - Case report anaphylactic reaction to praziquantel during schistosomiasis.pdfVasconcelo, Géssica Almeida - Case report anaphylactic reaction to praziquantel during schistosomiasis.pdfapplication/pdf34795https://arca.fiocruz.br/bitstreams/c762ffed-e9cb-405d-8215-4dd859df2370/downloadad3d1e810db66af85eec208f0d58b6f9MD52trueAnonymousREADTEXTVasconcelo, Géssica Almeida - 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Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| title |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| spellingShingle |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment Vasconcelos, Géssica Almeida Reação anafilática Praziquantel Esquistossomose Tratamento Anaphylactic reaction Praziquantel Schistosomiasis Treatment Anafilaxia Praziquantel Esquistossomose Terapêutica |
| title_short |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| title_full |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| title_fullStr |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| title_full_unstemmed |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| title_sort |
Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment |
| author |
Vasconcelos, Géssica Almeida |
| author_facet |
Vasconcelos, Géssica Almeida Costa, Bernardo Gratival Faria, Carolina Dourado de Schramm Neto, Fernando Antônio Ramos Machado, Yuri de Jesus Casaes, Ane Caroline Oliveira, Marcos Vinicius Lima de Fialho, Thainá Rodrigues de Souza Santos, Ronald Alves dos Santos, Keila Ramos dos Oliveira, Bruna Souza S. Oliveira, Ricardo Riccio Siqueira, Isadora Cristina de |
| author_role |
author |
| author2 |
Costa, Bernardo Gratival Faria, Carolina Dourado de Schramm Neto, Fernando Antônio Ramos Machado, Yuri de Jesus Casaes, Ane Caroline Oliveira, Marcos Vinicius Lima de Fialho, Thainá Rodrigues de Souza Santos, Ronald Alves dos Santos, Keila Ramos dos Oliveira, Bruna Souza S. Oliveira, Ricardo Riccio Siqueira, Isadora Cristina de |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcelos, Géssica Almeida Costa, Bernardo Gratival Faria, Carolina Dourado de Schramm Neto, Fernando Antônio Ramos Machado, Yuri de Jesus Casaes, Ane Caroline Oliveira, Marcos Vinicius Lima de Fialho, Thainá Rodrigues de Souza Santos, Ronald Alves dos Santos, Keila Ramos dos Oliveira, Bruna Souza S. Oliveira, Ricardo Riccio Siqueira, Isadora Cristina de |
| dc.subject.other.none.fl_str_mv |
Reação anafilática Praziquantel Esquistossomose Tratamento |
| topic |
Reação anafilática Praziquantel Esquistossomose Tratamento Anaphylactic reaction Praziquantel Schistosomiasis Treatment Anafilaxia Praziquantel Esquistossomose Terapêutica |
| dc.subject.en.none.fl_str_mv |
Anaphylactic reaction Praziquantel Schistosomiasis Treatment |
| dc.subject.decs.none.fl_str_mv |
Anafilaxia Praziquantel Esquistossomose Terapêutica |
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Fundação Oswaldo Cruz (FIOCRUZ), Instituto Gonçalo Moniz (IGM). |
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2022 |
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2022 |
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2024-06-17T14:30:43Z |
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2024-06-17T14:30:43Z |
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VASCONCELOS, Géssica Almeida et al. Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment. In: SIMPÓSIO INTERNACIONAL SOBRE ESQUISTOSSOMOSE, 16, 2022, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: Fiocruz, 21 a 23 de novembro de 2022. p.1. |
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https://arca.fiocruz.br/handle/icict/64513 |
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VASCONCELOS, Géssica Almeida et al. Case report: anaphylactic reaction to praziquantel during schistosomiasis treatment. In: SIMPÓSIO INTERNACIONAL SOBRE ESQUISTOSSOMOSE, 16, 2022, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: Fiocruz, 21 a 23 de novembro de 2022. p.1. |
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