Mechanism of action of glycyrrhizin against Plasmodium falciparum

Bibliographic Details
Main Author: Soeiro, Maria de Nazaré Correia
Publication Date: 2021
Other Authors: Vergoten, Gérard, Bailly, Christian
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0074-02760210084
Download full: https://arca.fiocruz.br/handle/icict/48916
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Soeiro, Maria de Nazaré CorreiaVergoten, GérardBailly, Christian2021-09-02T14:54:57Z2021-09-02T14:54:57Z2021SOEIRO, Maria de Nazaré Correia; VERGOTEN, Gérard; BAILLY, Christian. Mechanism of action of glycyrrhizin against Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210084, 7 p, 2021.0074-0276https://arca.fiocruz.br/handle/icict/4891610.1590/0074-027602100841678-8060engFiocruz/IOCMaláriaPlasmodiumGlyoxalase 1GlycyrrhizinColesterolCholesterolGlycyrrhizinGlyoxalase 1HMGB1, MalariaPlasmodiumMechanism of action of glycyrrhizin against Plasmodium falciparuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.University of Lille. Inserm. Institut de Chimie Pharmaceutique Albert Lespagnol. Faculté de Pharmacie. Lille, France.OncoWitan. Lille, France.Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/0d1c66c2-3bf9-4000-a4ab-269c5ede41a1/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALMaiaNSoeiro_etal_IOC_2021.pdfMaiaNSoeiro_etal_IOC_2021.pdfapplication/pdf1789587https://arca.fiocruz.br/bitstreams/26c9883c-5e12-49cc-813c-64316436919c/downloadb85807d58c5f3cb13baf88f91e6a58baMD52trueAnonymousREADTEXTMaiaNSoeiro_etal_IOC_2021.pdf.txtMaiaNSoeiro_etal_IOC_2021.pdf.txtExtracted texttext/plain31462https://arca.fiocruz.br/bitstreams/764ab025-4bec-4ff9-a89a-e2d8812695b6/download99c1c953b1ce80351a61f1e91639b865MD57falseAnonymousREADTHUMBNAILMaiaNSoeiro_etal_IOC_2021.pdf.jpgMaiaNSoeiro_etal_IOC_2021.pdf.jpgGenerated Thumbnailimage/jpeg5766https://arca.fiocruz.br/bitstreams/1b55551c-b700-4c33-9c8e-faf27b2e705d/download958405ec49ed64d43b3ea7f755acc474MD58falseAnonymousREADicict/489162025-07-31 13:23:50.294open.accessoai:arca.fiocruz.br:icict/48916https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-31T16:23:50Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Mechanism of action of glycyrrhizin against Plasmodium falciparum
title Mechanism of action of glycyrrhizin against Plasmodium falciparum
spellingShingle Mechanism of action of glycyrrhizin against Plasmodium falciparum
Soeiro, Maria de Nazaré Correia
Malária
Plasmodium
Glyoxalase 1
Glycyrrhizin
Colesterol
Cholesterol
Glycyrrhizin
Glyoxalase 1
HMGB1, Malaria
Plasmodium
title_short Mechanism of action of glycyrrhizin against Plasmodium falciparum
title_full Mechanism of action of glycyrrhizin against Plasmodium falciparum
title_fullStr Mechanism of action of glycyrrhizin against Plasmodium falciparum
title_full_unstemmed Mechanism of action of glycyrrhizin against Plasmodium falciparum
title_sort Mechanism of action of glycyrrhizin against Plasmodium falciparum
author Soeiro, Maria de Nazaré Correia
author_facet Soeiro, Maria de Nazaré Correia
Vergoten, Gérard
Bailly, Christian
author_role author
author2 Vergoten, Gérard
Bailly, Christian
author2_role author
author
dc.contributor.author.fl_str_mv Soeiro, Maria de Nazaré Correia
Vergoten, Gérard
Bailly, Christian
dc.subject.other.none.fl_str_mv Malária
Plasmodium
Glyoxalase 1
Glycyrrhizin
Colesterol
topic Malária
Plasmodium
Glyoxalase 1
Glycyrrhizin
Colesterol
Cholesterol
Glycyrrhizin
Glyoxalase 1
HMGB1, Malaria
Plasmodium
dc.subject.en.none.fl_str_mv Cholesterol
Glycyrrhizin
Glyoxalase 1
HMGB1, Malaria
Plasmodium
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-02T14:54:57Z
dc.date.available.fl_str_mv 2021-09-02T14:54:57Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOEIRO, Maria de Nazaré Correia; VERGOTEN, Gérard; BAILLY, Christian. Mechanism of action of glycyrrhizin against Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210084, 7 p, 2021.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/48916
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760210084
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SOEIRO, Maria de Nazaré Correia; VERGOTEN, Gérard; BAILLY, Christian. Mechanism of action of glycyrrhizin against Plasmodium falciparum. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210084, 7 p, 2021.
0074-0276
10.1590/0074-02760210084
1678-8060
url https://arca.fiocruz.br/handle/icict/48916
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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