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Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis

Bibliographic Details
Main Author: Machado, Marina Amaral de Avila
Publication Date: 2013
Other Authors: Barbosa, Mariana Michel, Almeida, Alessandra Maciel, Araujo, Vania Eloisa de, Kakehasi, Adriana Maria, Andrade, Eli Iola Gurgel, Cherchiglia, Mariangela Leal, Acurcio, Francisco de Assis
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1007/s00296-013-2772-6
Download full: https://arca.fiocruz.br/handle/icict/30115
Summary: 2020-01-01
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spelling Machado, Marina Amaral de AvilaBarbosa, Mariana MichelAlmeida, Alessandra MacielAraujo, Vania Eloisa deKakehasi, Adriana MariaAndrade, Eli Iola GurgelCherchiglia, Mariangela LealAcurcio, Francisco de Assis2018-11-20T17:08:24Z2018-11-20T17:08:24Z2013MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 20130172-8172https://arca.fiocruz.br/handle/icict/3011510.1007/s00296-013-2772-6engSpringer InternationalEspondilite anquilosanteBloqueadores de TNFRevisão sistemáticaMeta-análiseAnkylosing spondylitisTNF blockersSystematic reviewMeta-analysisTreatment of ankylosing spondylitis with TNF blockers: a meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, BrazilFaculdade de Ciências Médicas. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilBiological agents directed against tumor necrosis factor (TNF) represent therapeutic options for patients with ankylosing spondylitis with high disease activity despite use of non-steroidal anti-inflammatory drugs. To evaluate the efficacy and safety of the anti-TNF agents infliximab, etanercept, adalimumab, golimumab, and certolizumab for the treatment of ankylosing spondylitis, we performed a systematic review of randomized clinical trials on adult patients with ankylosing spondylitis using articles culled from the EMBASE, MEDLINE, Cochrane Controlled Trials Register and LILACS databases (September/2012), manual literature search, and the gray literature. Study selections and data collection were performed by two independent reviewers, with disagreements solved by a third reviewer. The following outcomes were evaluated: ASAS 20 response, disease activity, physical function, vertebral mobility, adverse events, and withdraws. The meta-analysis was performed using the Review Manager(®) 5.1 software by applying the random effects model. Eighteen studies were included in this review. No study of certolizumab was included. Patients treated with anti-TNF agents were more likely to display an ASAS 20 response after 12/14 weeks (RR 2.21; 95 % CI 1.91; 2.56) and 24 weeks (RR 2.68; 95 % CI 2.06; 3.48) compared with controls, which was also true for several other efficacy outcomes. Meta-analysis of safety outcomes and withdraws did not indicate statistically significant differences between treatment and control groups after 12 or 30 weeks. Adalimumab, infliximab, etanercept, and golimumab can effectively reduce the signs and symptoms of the axial component of ankylosing spondylitis. Safety outcomes deserve further study, especially with respect to long-term follow-ups.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://arca.fiocruz.br/bitstreams/7fcce7b6-c0d6-4553-8f9e-b491acf2d560/download9193a7c197bc67acd023525e72a03240MD51falseAnonymousREADORIGINALTreatment of ankylosing .pdfTreatment of ankylosing .pdfapplication/pdf1256965https://arca.fiocruz.br/bitstreams/a1dade49-b434-42d5-9057-3527621e0eac/download954ff7a39d1a7b1a1ae27ec633032821MD52trueAnonymousREAD2020-01-01TEXTTreatment of ankylosing .pdf.txtTreatment of ankylosing .pdf.txtExtracted texttext/plain59211https://arca.fiocruz.br/bitstreams/dffac74c-a22f-472b-aa63-42a24d3f1786/downloadbb9b289f67989cb06c6d5407c4576e32MD55falseAnonymousREAD2020-01-01THUMBNAILTreatment of ankylosing .pdf.jpgTreatment of ankylosing .pdf.jpgGenerated Thumbnailimage/jpeg5356https://arca.fiocruz.br/bitstreams/52cc090e-7107-424d-adc2-442d1cf8ba1f/download8417f743dd264b074eb671b285b7aa57MD56falseAnonymousREAD2020-01-01icict/301152025-07-30 01:16:28.369open.accessoai:arca.fiocruz.br:icict/30115https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:16:28Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
title Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
spellingShingle Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
Machado, Marina Amaral de Avila
Espondilite anquilosante
Bloqueadores de TNF
Revisão sistemática
Meta-análise
Ankylosing spondylitis
TNF blockers
Systematic review
Meta-analysis
title_short Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
title_full Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
title_fullStr Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
title_full_unstemmed Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
title_sort Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis
author Machado, Marina Amaral de Avila
author_facet Machado, Marina Amaral de Avila
Barbosa, Mariana Michel
Almeida, Alessandra Maciel
Araujo, Vania Eloisa de
Kakehasi, Adriana Maria
Andrade, Eli Iola Gurgel
Cherchiglia, Mariangela Leal
Acurcio, Francisco de Assis
author_role author
author2 Barbosa, Mariana Michel
Almeida, Alessandra Maciel
Araujo, Vania Eloisa de
Kakehasi, Adriana Maria
Andrade, Eli Iola Gurgel
Cherchiglia, Mariangela Leal
Acurcio, Francisco de Assis
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Marina Amaral de Avila
Barbosa, Mariana Michel
Almeida, Alessandra Maciel
Araujo, Vania Eloisa de
Kakehasi, Adriana Maria
Andrade, Eli Iola Gurgel
Cherchiglia, Mariangela Leal
Acurcio, Francisco de Assis
dc.subject.other.none.fl_str_mv Espondilite anquilosante
Bloqueadores de TNF
Revisão sistemática
Meta-análise
topic Espondilite anquilosante
Bloqueadores de TNF
Revisão sistemática
Meta-análise
Ankylosing spondylitis
TNF blockers
Systematic review
Meta-analysis
dc.subject.en.none.fl_str_mv Ankylosing spondylitis
TNF blockers
Systematic review
Meta-analysis
description 2020-01-01
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-11-20T17:08:24Z
dc.date.available.fl_str_mv 2018-11-20T17:08:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 2013
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/30115
dc.identifier.issn.none.fl_str_mv 0172-8172
dc.identifier.doi.none.fl_str_mv 10.1007/s00296-013-2772-6
identifier_str_mv MACHADO, Marina Amaral de Avila et al. Treatment of ankylosing spondylitis with TNF blockers: a meta-analysis. Rheumatol Int., v. 33, n. 9, p. 2199-213, 2013
0172-8172
10.1007/s00296-013-2772-6
url https://arca.fiocruz.br/handle/icict/30115
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer International
publisher.none.fl_str_mv Springer International
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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