The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis
| Main Author: | |
|---|---|
| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3389/fimmu.2024.1357360 |
| Download full: | https://arca.fiocruz.br/handle/icict/65144 |
Summary: | Produção científica do Laboratório Interdisciplinar de Pesquisas Médicas. |
| id |
CRUZ_c83cdf1ad3356bd9f3437f5f4d8b3c76 |
|---|---|
| oai_identifier_str |
oai:arca.fiocruz.br:icict/65144 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Xavier, Mariana SimaoPereira, Mariana AraújoOliveira, Quézia Medeiros deSant'Anna, Flavia MarinhoRidolfi, Felipe MoreiraAndrade, Alice Motta Soares deFigueiredo, Marina C.Sterling, Timothy R.Gordhan, Bhavna G.Kana, Bavesh D.Andrade, Bruno de BezerrilRolla, Valeria CavalcantiSilva, Adriano Gomes da2024-07-24T16:47:39Z2024-07-24T16:47:39Z2024XAVIER, Mariana Simao et al. The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis. Frontiers in Immunology, v. 15, p. 1-11, 27 June 2024.1664-3224https://arca.fiocruz.br/handle/icict/6514410.3389/fimmu.2024.13573601664-3224Produção científica do Laboratório Interdisciplinar de Pesquisas Médicas.The author(s) declare financial support was received for the research, authorship, and/or publication of this article.This protocol was funded by the Brazilian Council of Research (CNPq-BRICS, ABRICOT 440933/2020-0), CRDF (National Institutes of Health) and FAPERJ (E-26/210.238/2020).Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Programa de Pós-Graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Faculdade ZARNS. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Vanderbilt University Medical Center. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.University of the Witwatersrand. National Health Laboratory Service. Faculty of Health Sciences. School of Pathology. Centre of Excellence for Biomedical Tuberculosis Research. National Research Foundation. Department of Science and Innovation. Johannesburg, South Africa.University of the Witwatersrand. National Health Laboratory Service. Faculty of Health Sciences. School of Pathology. Centre of Excellence for Biomedical Tuberculosis Research. National Research Foundation. Department of Science and Innovation. Johannesburg, South Africa.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Faculdade ZARNS. Curso de Medicina. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.Background: The impact of previous SARS-CoV-2 infection on the systemic immune response during tuberculosis (TB) disease has not been explored. Methods: An observational, cross-sectional cohort was established to evaluate the systemic immune response in persons with pulmonary tuberculosis with or without previous SARS-CoV-2 infection. Those participants were recruited in an outpatient referral clinic in Rio de Janeiro, Brazil. TB was defined as a positive Xpert-MTB/RIF Ultra and/or a positive culture of Mycobacterium tuberculosis from sputum. Stored plasma was used to perform specific serology to identify previous SARS-CoV-2 infection (TB/Prex-SCoV-2 group) and confirm the non- infection of the tuberculosis group (TB group). Plasmatic cytokine/chemokine/growth factor profiling was performed using Luminex technology. Tuberculosis severity was assessed by clinical and laboratory parameters. Participants from TB group (4.55%) and TB/Prex-SCoV-2 (0.00%) received the complete COVID-19 vaccination. Results: Among 35 participants with pulmonary TB, 22 were classified as TB/Prex-SCoV-2. The parameters associated with TB severity, together with hematologic and biochemical data were similar between the TB and TB/Prex-SCoV-2 groups. Among the signs and symptoms, fever and dyspnea were significantly more frequent in the TB group than the TB/Prex-SCoV-2 group (p < 0,05). A signature based on lower amount of plasma EGF, G-CSF, GM-CSF, IFN-α2, IL-12(p70), IL-13, IL-15, IL-17, IL-1β, IL-5, IL-7, and TNF-β was observed in the TB/Prex-SCoV-2 group. In contrast, MIP-1β was significantly higher in the TB/Prex-SCoV-2 group than the TB group. Conclusion: TB patients previously infected with SARS-CoV-2 had an immunomodulation that was associated with lower plasma concentrations of soluble factors associated with systemic inflammation. This signature was associated with a lower frequency of symptoms such as fever and dyspnea but did not reflect significant differences in TB severity parameters observed at baseline.engFrontiers MediaThe effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTuberculosisSARS-CoV-2Immune responsePrevious infectionDisease severityImmunomodulationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTHUMBNAILcapa_Mariana_Xavier_etal_INI_2024.jpgcapa_Mariana_Xavier_etal_INI_2024.jpgCapaimage/jpeg2314656https://arca.fiocruz.br/bitstreams/8277cf87-9d7b-4193-8aef-3b53487fd9e9/downloade360895dec658c0bdbb5ee39b1c696d6MD53falseAnonymousREADve_Mariana_Xavier_etal_INI_2024.pdf.jpgve_Mariana_Xavier_etal_INI_2024.pdf.jpgGenerated Thumbnailimage/jpeg4910https://arca.fiocruz.br/bitstreams/3a4be4ef-59e2-4d70-80c0-0409c480843b/download651b953c1a0242edb0e8e581bbd0382cMD57falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/5f78ff1f-31d2-423f-9398-3a51e82b0a81/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALve_Mariana_Xavier_etal_INI_2024.pdfve_Mariana_Xavier_etal_INI_2024.pdfapplication/pdf850203https://arca.fiocruz.br/bitstreams/53435524-3f0f-4a90-ae4d-5dad7b93944c/downloada34cca1cd76244dae81173564440a734MD52trueAnonymousREADTEXTve_Mariana_Xavier_etal_INI_2024.pdf.txtve_Mariana_Xavier_etal_INI_2024.pdf.txtExtracted texttext/plain63411https://arca.fiocruz.br/bitstreams/9258744e-2303-4b11-871f-fd0d3751afab/download6b2d3a821a5cac91d267e3009f957185MD56falseAnonymousREADicict/651442025-07-29 21:20:41.617open.accessoai:arca.fiocruz.br:icict/65144https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T00:20:41Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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 |
| dc.title.none.fl_str_mv |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| title |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| spellingShingle |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis Xavier, Mariana Simao Tuberculosis SARS-CoV-2 Immune response Previous infection Disease severity Immunomodulation |
| title_short |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| title_full |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| title_fullStr |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| title_full_unstemmed |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| title_sort |
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis |
| author |
Xavier, Mariana Simao |
| author_facet |
Xavier, Mariana Simao Pereira, Mariana Araújo Oliveira, Quézia Medeiros de Sant'Anna, Flavia Marinho Ridolfi, Felipe Moreira Andrade, Alice Motta Soares de Figueiredo, Marina C. Sterling, Timothy R. Gordhan, Bhavna G. Kana, Bavesh D. Andrade, Bruno de Bezerril Rolla, Valeria Cavalcanti Silva, Adriano Gomes da |
| author_role |
author |
| author2 |
Pereira, Mariana Araújo Oliveira, Quézia Medeiros de Sant'Anna, Flavia Marinho Ridolfi, Felipe Moreira Andrade, Alice Motta Soares de Figueiredo, Marina C. Sterling, Timothy R. Gordhan, Bhavna G. Kana, Bavesh D. Andrade, Bruno de Bezerril Rolla, Valeria Cavalcanti Silva, Adriano Gomes da |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Xavier, Mariana Simao Pereira, Mariana Araújo Oliveira, Quézia Medeiros de Sant'Anna, Flavia Marinho Ridolfi, Felipe Moreira Andrade, Alice Motta Soares de Figueiredo, Marina C. Sterling, Timothy R. Gordhan, Bhavna G. Kana, Bavesh D. Andrade, Bruno de Bezerril Rolla, Valeria Cavalcanti Silva, Adriano Gomes da |
| dc.subject.en.none.fl_str_mv |
Tuberculosis SARS-CoV-2 Immune response Previous infection Disease severity Immunomodulation |
| topic |
Tuberculosis SARS-CoV-2 Immune response Previous infection Disease severity Immunomodulation |
| description |
Produção científica do Laboratório Interdisciplinar de Pesquisas Médicas. |
| publishDate |
2024 |
| dc.date.accessioned.fl_str_mv |
2024-07-24T16:47:39Z |
| dc.date.available.fl_str_mv |
2024-07-24T16:47:39Z |
| dc.date.issued.fl_str_mv |
2024 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
XAVIER, Mariana Simao et al. The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis. Frontiers in Immunology, v. 15, p. 1-11, 27 June 2024. |
| dc.identifier.uri.fl_str_mv |
https://arca.fiocruz.br/handle/icict/65144 |
| dc.identifier.issn.none.fl_str_mv |
1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2024.1357360 |
| dc.identifier.eissn.none.fl_str_mv |
1664-3224 |
| identifier_str_mv |
XAVIER, Mariana Simao et al. The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis. Frontiers in Immunology, v. 15, p. 1-11, 27 June 2024. 1664-3224 10.3389/fimmu.2024.1357360 |
| url |
https://arca.fiocruz.br/handle/icict/65144 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://arca.fiocruz.br/bitstreams/8277cf87-9d7b-4193-8aef-3b53487fd9e9/download https://arca.fiocruz.br/bitstreams/3a4be4ef-59e2-4d70-80c0-0409c480843b/download https://arca.fiocruz.br/bitstreams/5f78ff1f-31d2-423f-9398-3a51e82b0a81/download https://arca.fiocruz.br/bitstreams/53435524-3f0f-4a90-ae4d-5dad7b93944c/download https://arca.fiocruz.br/bitstreams/9258744e-2303-4b11-871f-fd0d3751afab/download |
| bitstream.checksum.fl_str_mv |
e360895dec658c0bdbb5ee39b1c696d6 651b953c1a0242edb0e8e581bbd0382c 5a560609d32a3863062d77ff32785d58 a34cca1cd76244dae81173564440a734 6b2d3a821a5cac91d267e3009f957185 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1839716039770767360 |