Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation

Bibliographic Details
Main Author: Innocenzi, Adriana
Publication Date: 2025
Other Authors: Rangel, Isabela, Póvoa‑corrêa, Mariana, Parente, Daniella Braz, Perez, Renata, Rodrigues, Rosana Souza, Fukuyama, Lúcia Tomoko, Barroso, Julia Machado, Oliveira Neto, Jaime Araújo, Sousa, Andrea Silvestre de, Luiz, Ronir Raggio, Barbosa, Rosa Célia Pimentel, Camargo, Gabriel Cordeiro, Moll‑bernardes, Renata
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1007/s00246-024-03522-9
Download full: https://arca.fiocruz.br/handle/icict/69456
Summary: This work was supported by D’Or Institute for Research and Education (IDOR) and FAPERJ (# E-26/010.002144/2019; #E-26/010.001806/2019).
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spelling Innocenzi, AdrianaRangel, IsabelaPóvoa‑corrêa, MarianaParente, Daniella BrazPerez, RenataRodrigues, Rosana SouzaFukuyama, Lúcia TomokoBarroso, Julia MachadoOliveira Neto, Jaime AraújoSousa, Andrea Silvestre deLuiz, Ronir RaggioBarbosa, Rosa Célia PimentelCamargo, Gabriel CordeiroMoll‑bernardes, Renata2025-04-07T23:42:38Z2025-04-07T23:42:38Z2025INNOCENZI, Adriana et al. Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation. Pediatric Cardiology, v. 46, n. 4, p. 966-975, Apr. 2025.0172-0643https://arca.fiocruz.br/handle/icict/6945610.1007/s00246-024-03522-91432-1971This work was supported by D’Or Institute for Research and Education (IDOR) and FAPERJ (# E-26/010.002144/2019; #E-26/010.001806/2019).D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Macaé, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.The abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann-Whitney, Fisher exact test, and Spearman's correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stiffness. The mean native cardiac T1 value (p = 0.018), cardiac ECV (p < 0.001), liver native T1 (p < 0.001), liver ECV (p < 0.001), and liver stiffness (p < 0.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (r = 0.356; p = 0.033), native liver T1 (r = 0.571; p < 0.001), and with liver stiffness (r = 0.391; p = 0.015). In addition, liver stiffness correlated with liver ECV (r = 0.361; p = 0.031) and native liver T1 (r = 0.458; p = 0.004). An association between cardiac remodeling and cardiac and liver fibrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.engSpringerCardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFontanFibrosisT1 mappingExtracellular volumeMRIFontan-associated liver diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/e868f819-16a3-4977-87be-adf66667da6e/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALAdriana Innocenzi_etal_INI_2025.pdfAdriana Innocenzi_etal_INI_2025.pdfapplication/pdf1268686https://arca.fiocruz.br/bitstreams/625cfcf9-670c-43a8-afbc-b816935ae9a9/download18c2c660d4598204edf97206d10c96edMD52trueAnonymousREADTHUMBNAILcapa_page-0001.jpgcapa_page-0001.jpgimage/jpeg839606https://arca.fiocruz.br/bitstreams/03b225ed-c7c5-4341-a46d-2b676e551347/download4ed03a2a0abe0b9035f83a72f3034de9MD53falseAnonymousREADAdriana Innocenzi_etal_INI_2025.pdf.jpgAdriana Innocenzi_etal_INI_2025.pdf.jpgGenerated Thumbnailimage/jpeg5843https://arca.fiocruz.br/bitstreams/da1e59dd-2d72-4640-a4b4-a854e1522cd2/downloada3c3f5f37a552c90446a1ec0b9152bdcMD59falseAnonymousREADTEXTAdriana Innocenzi_etal_INI_2025.pdf.txtAdriana Innocenzi_etal_INI_2025.pdf.txtExtracted texttext/plain50698https://arca.fiocruz.br/bitstreams/3a5e2345-c74d-4cdf-a42d-4c6fe9c981f4/download448f3c4e3115d8d3f66ffdcbbd732d0fMD58falseAnonymousREADicict/694562025-07-29 19:34:57.392open.accessoai:arca.fiocruz.br:icict/69456https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:34:57Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
title Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
spellingShingle Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
Innocenzi, Adriana
Fontan
Fibrosis
T1 mapping
Extracellular volume
MRI
Fontan-associated liver disease
title_short Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
title_full Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
title_fullStr Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
title_full_unstemmed Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
title_sort Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
author Innocenzi, Adriana
author_facet Innocenzi, Adriana
Rangel, Isabela
Póvoa‑corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andrea Silvestre de
Luiz, Ronir Raggio
Barbosa, Rosa Célia Pimentel
Camargo, Gabriel Cordeiro
Moll‑bernardes, Renata
author_role author
author2 Rangel, Isabela
Póvoa‑corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andrea Silvestre de
Luiz, Ronir Raggio
Barbosa, Rosa Célia Pimentel
Camargo, Gabriel Cordeiro
Moll‑bernardes, Renata
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Innocenzi, Adriana
Rangel, Isabela
Póvoa‑corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andrea Silvestre de
Luiz, Ronir Raggio
Barbosa, Rosa Célia Pimentel
Camargo, Gabriel Cordeiro
Moll‑bernardes, Renata
dc.subject.en.none.fl_str_mv Fontan
Fibrosis
T1 mapping
Extracellular volume
MRI
Fontan-associated liver disease
topic Fontan
Fibrosis
T1 mapping
Extracellular volume
MRI
Fontan-associated liver disease
description This work was supported by D’Or Institute for Research and Education (IDOR) and FAPERJ (# E-26/010.002144/2019; #E-26/010.001806/2019).
publishDate 2025
dc.date.accessioned.fl_str_mv 2025-04-07T23:42:38Z
dc.date.available.fl_str_mv 2025-04-07T23:42:38Z
dc.date.issued.fl_str_mv 2025
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv INNOCENZI, Adriana et al. Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation. Pediatric Cardiology, v. 46, n. 4, p. 966-975, Apr. 2025.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/69456
dc.identifier.issn.none.fl_str_mv 0172-0643
dc.identifier.doi.none.fl_str_mv 10.1007/s00246-024-03522-9
dc.identifier.eissn.none.fl_str_mv 1432-1971
identifier_str_mv INNOCENZI, Adriana et al. Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation. Pediatric Cardiology, v. 46, n. 4, p. 966-975, Apr. 2025.
0172-0643
10.1007/s00246-024-03522-9
1432-1971
url https://arca.fiocruz.br/handle/icict/69456
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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