Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities

Bibliographic Details
Main Author: Caixeta, Eliane Vasconcelos
Publication Date: 2024
Other Authors: Diniz, Danielle Guimarães Almeida, Torres, Ieda Maria Sapateiro, Campos, Laila Portil Garcino, Machado, Rúbia Darc, Andréo, Bruna Gandorfini Chiari, Isaac, Vera Lucia Borges, Bara, Maria Teresa Freitas
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.32712/2446-4775.2024.1228
Download full: https://arca.fiocruz.br/handle/icict/68805
Summary: Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.
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spelling Caixeta, Eliane VasconcelosDiniz, Danielle Guimarães AlmeidaTorres, Ieda Maria SapateiroCampos, Laila Portil GarcinoMachado, Rúbia DarcAndréo, Bruna Gandorfini ChiariIsaac, Vera Lucia BorgesBara, Maria Teresa Freitas2025-03-06T17:57:47Z2025-03-06T17:57:47Z2024CAIXETA, Eliane Vasconcelos et al. Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities. Revista Fitos, Rio de Janeiro, v. 18, p. 1-10, 2024.1808-9569https://arca.fiocruz.br/handle/icict/6880510.32712/2446-4775.2024.1228engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos.Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de tecnologia farmacêutica. Goiânia, GO, Brasil.Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de controle de qualidade de medicamentos. Goiânia, GO, Brasil.Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.Universidade de Araraquara. Araraquara, SP, Brasil.Universidade Estadual Paulista Júlio de Mesquita Filho. Faculdade de ciências farmacêuticas. Araraquara, SP, Brasil.Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.Lafoensia pacari`s leaves have phenolic compounds which may lead to photoprotective and antioxidant properties. The aim of this study was to investigate these activities in the L. pacari phenolics-containing extract (LPE) and to obtain gel cream formulations containing LPE and that have photochemoprotective activity. Phenolic compounds and antioxidant activity were determined. Polyacrylamide & C13-14 Isoparaffin & Laureth-7 (Focus gel® 305) formulation, it added synthetic sunscreen Ethylhexyl methoxycinnamate (Eusolex 2292®) or with both Eusolex 2292® and LPE were prepared. The in vitro sun protection factor (SPF) of these formulations was determined by diffuse reflectance spectroscopy. Preliminary stability of gel creams was evaluated. Total phenols and flavonoids content were 3.31% and 0.315%, respectively. LPE showed antioxidant activity by DPPH, with an EC50 of 5.3 µg. mL-1 and by FRAP methods, in which 1g of the extract reduces 323.62 µM/L of ferrous sulfate. LPE showed an additive effect on the value of SPF when associated with Ethylhexyl methoxycinnamate, an increase of 22% in FPS of the formulation (F3). The data obtained allow us to suggest a trend towards the photoquimoprotective effect of the L. pacari phenolics-containing extract in the studied conditions.Herbal medicinalSun protection factorAdditive effect on sun protectionPhotochemoprotectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/63aca9cf-1971-4c10-9a42-7e131aa550e5/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADORIGINAL1228-FINAL-20241128.pdfapplication/pdf356447https://arca.fiocruz.br/bitstreams/0f589c0c-a106-49f7-a29f-20d568076869/downloadf89d7854c0d202f552442fa1a2631ab9MD52trueAnonymousREADTEXT1228-FINAL-20241128.pdf.txt1228-FINAL-20241128.pdf.txtExtracted texttext/plain33060https://arca.fiocruz.br/bitstreams/81f22372-f828-44f1-923a-a1238750754a/download4896a4cb990f9d62a10206f90ae088a6MD55falseAnonymousREADTHUMBNAIL1228-FINAL-20241128.pdf.jpg1228-FINAL-20241128.pdf.jpgGenerated Thumbnailimage/jpeg5462https://arca.fiocruz.br/bitstreams/c86fea41-8b54-4ca3-ac23-02d71194ddf5/download8f1ad2fc2d655017462bebb2c0928fb3MD56falseAnonymousREADicict/688052025-07-30 02:20:12.514open.accessoai:arca.fiocruz.br:icict/68805https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T05:20:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
title Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
spellingShingle Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
Caixeta, Eliane Vasconcelos
Herbal medicinal
Sun protection factor
Additive effect on sun protection
Photochemoprotection
title_short Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
title_full Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
title_fullStr Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
title_full_unstemmed Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
title_sort Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities
author Caixeta, Eliane Vasconcelos
author_facet Caixeta, Eliane Vasconcelos
Diniz, Danielle Guimarães Almeida
Torres, Ieda Maria Sapateiro
Campos, Laila Portil Garcino
Machado, Rúbia Darc
Andréo, Bruna Gandorfini Chiari
Isaac, Vera Lucia Borges
Bara, Maria Teresa Freitas
author_role author
author2 Diniz, Danielle Guimarães Almeida
Torres, Ieda Maria Sapateiro
Campos, Laila Portil Garcino
Machado, Rúbia Darc
Andréo, Bruna Gandorfini Chiari
Isaac, Vera Lucia Borges
Bara, Maria Teresa Freitas
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caixeta, Eliane Vasconcelos
Diniz, Danielle Guimarães Almeida
Torres, Ieda Maria Sapateiro
Campos, Laila Portil Garcino
Machado, Rúbia Darc
Andréo, Bruna Gandorfini Chiari
Isaac, Vera Lucia Borges
Bara, Maria Teresa Freitas
dc.subject.en.none.fl_str_mv Herbal medicinal
Sun protection factor
Additive effect on sun protection
Photochemoprotection
topic Herbal medicinal
Sun protection factor
Additive effect on sun protection
Photochemoprotection
description Universidade Federal De Goiás. Faculdade de Farmácia. Laboratório de pesquisa de produtos naturais. Goiânia, GO, Brasil.
publishDate 2024
dc.date.issued.fl_str_mv 2024
dc.date.accessioned.fl_str_mv 2025-03-06T17:57:47Z
dc.date.available.fl_str_mv 2025-03-06T17:57:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAIXETA, Eliane Vasconcelos et al. Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities. Revista Fitos, Rio de Janeiro, v. 18, p. 1-10, 2024.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/68805
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2024.1228
identifier_str_mv CAIXETA, Eliane Vasconcelos et al. Gel cream loaded with Lafoensia pacari phenolics-containing extract with antioxidant and photoprotective activities. Revista Fitos, Rio de Janeiro, v. 18, p. 1-10, 2024.
1808-9569
10.32712/2446-4775.2024.1228
url https://arca.fiocruz.br/handle/icict/68805
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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