Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis
| Main Author: | |
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| Publication Date: | 2019 |
| Other Authors: | , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1093/ofid/ofz520 |
| Download full: | https://arca.fiocruz.br/handle/icict/39558 |
Summary: | C.D.F. is supported by scholarship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.B.A. and P.M. receive a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.Cl.M.C. and C.L.V. are supported by CNPq (Brazilian National Council for Scientific and Technological Development). M.Ca.M.C. receives a scholarship from the Faculdade de Tecnologia e Ciências (FTC). B.B.A. and K.F. are supported by the intramural research program of FIOCRUZ. B.B.A. receives a senior fellowship from CNPq. |
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Fernandes, Catarina D.Arriaga Gutiérrez, María BelenCosta, Maria Carolina M.Costa, Maria Clara M.Costa, Maria Heloina M.Vinhaes, Caian LealMattos, Paulo Sérgio de Morais da SilveiraFukutani, Kiyoshi FerreiraAndrade, Bruno de Bezerril2020-01-28T14:35:29Z2020-01-28T14:35:29Z2019FERNANDES, Catarina D. et al. Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, p. 1-13, 2019.2328-8957https://arca.fiocruz.br/handle/icict/3955810.1093/ofid/ofz520C.D.F. is supported by scholarship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.B.A. and P.M. receive a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.Cl.M.C. and C.L.V. are supported by CNPq (Brazilian National Council for Scientific and Technological Development). M.Ca.M.C. receives a scholarship from the Faculdade de Tecnologia e Ciências (FTC). B.B.A. and K.F. are supported by the intramural research program of FIOCRUZ. B.B.A. receives a senior fellowship from CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Universidade Federal da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil / Universidade Federal da Bahia. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, Tennessee, USA / University of Cape Town. Wellcome Centre for Infectious Disease Research in Africa. Institute of Infectious Disease and Molecular Medicine. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Community-acquired pneumonia (CAP) is the leading cause of death in children. Identification of reliable biomarkers offers the potential to develop a severity quantitative score to assist in clinical decision-making and improve outcomes. Methods. A systematic review and meta-analysis was performed in PubMed and EMBASE on November 13, 2018, to examine the association between host inflammatory biomarkers and CAP severity in children. The inclusion criteria were case–control, cross-sectional, and cohort studies that examined candidate serum biomarkers. We extracted outcomes of interest, means, and standardized mean differences (SMDs) of plasma and serum levels of biomarkers together with information on disease severity. Meta-analysis was performed. This review was registered in the PROSPERO international registry (CRD42019123351). Results. Two hundred seventy-two abstracts were identified, and 17 studies were included. Among the biomarkers evaluated, levels of C-reactive protein (CRP; SMD, 0.63; 95% confidence interval [CI], 0.35 to 0.91), interleukin (IL)-6 (SMD, 0.46; 95% CI, 0.25 to 0.66), IL-8 (SMD, 0.72; 95% CI, 0.15 to 1.29), neutrophil count (SMD, 0.27; 95% CI, 0.07 to 0.47), and procalcitonin (SMD, 0.68; 95% CI, 0.20 to 1.15) were substantially increased in severe CAP. In contrast, IL-2 concentrations (SMD, –0.24; 95% CI, –0.45 to –0.03) were higher in nonsevere CAP. Study heterogeneity was reported to be high (I2 > 75%), except for IL-2, IL-5, IL-6, and IL-12p70, which were classified as moderate (I2 = 50%–74%). Only neutrophil and white blood cell counts were described by studies exhibiting a low level of heterogeneity. Conclusions. Our results suggest that host biomarkers, and especially CRP, IL-6, IL-8, and procalcitonin levels, have the potential to predict severe CAP in pediatric populations.engOxford University PressBiomarcadoresCriançasInflamaçãoPneumoniaGravidadeBiomarkersChildrenInflammationPneumoniaSeverityHost Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/043b852b-547e-48e2-8564-c86b696569fc/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALFernandes C D Host Inflammatory Open Forum Infect Dis.pdfFernandes C D Host Inflammatory Open Forum Infect Dis.pdfapplication/pdf894401https://arca.fiocruz.br/bitstreams/052b6209-2815-40c4-97ff-27a349b6a963/download556bfb1cbbe318ff6e68db2a2fa00f6eMD52trueAnonymousREADTEXTFernandes C D Host Inflammatory Open Forum Infect Dis.pdf.txtFernandes C D Host Inflammatory Open Forum Infect Dis.pdf.txtExtracted texttext/plain68636https://arca.fiocruz.br/bitstreams/aa6757ae-3d17-4d89-94ea-d3771e967942/download8af54b1079c3841857c433bb8509a2cbMD57falseAnonymousREADTHUMBNAILFernandes C D Host Inflammatory Open Forum Infect Dis.pdf.jpgFernandes C D Host Inflammatory Open Forum Infect Dis.pdf.jpgGenerated Thumbnailimage/jpeg6377https://arca.fiocruz.br/bitstreams/5e4971b2-d8d4-4162-94bb-9df88a563f51/download4eeae39f8d744e1e43fda4694547f7abMD58falseAnonymousREADicict/395582025-07-29 19:34:03.132open.accessoai:arca.fiocruz.br:icict/39558https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:34:03Repositório Institucional da FIOCRUZ (ARCA) - 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Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| title |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| spellingShingle |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis Fernandes, Catarina D. Biomarcadores Crianças Inflamação Pneumonia Gravidade Biomarkers Children Inflammation Pneumonia Severity |
| title_short |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| title_full |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| title_fullStr |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| title_full_unstemmed |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| title_sort |
Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis |
| author |
Fernandes, Catarina D. |
| author_facet |
Fernandes, Catarina D. Arriaga Gutiérrez, María Belen Costa, Maria Carolina M. Costa, Maria Clara M. Costa, Maria Heloina M. Vinhaes, Caian Leal Mattos, Paulo Sérgio de Morais da Silveira Fukutani, Kiyoshi Ferreira Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Arriaga Gutiérrez, María Belen Costa, Maria Carolina M. Costa, Maria Clara M. Costa, Maria Heloina M. Vinhaes, Caian Leal Mattos, Paulo Sérgio de Morais da Silveira Fukutani, Kiyoshi Ferreira Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fernandes, Catarina D. Arriaga Gutiérrez, María Belen Costa, Maria Carolina M. Costa, Maria Clara M. Costa, Maria Heloina M. Vinhaes, Caian Leal Mattos, Paulo Sérgio de Morais da Silveira Fukutani, Kiyoshi Ferreira Andrade, Bruno de Bezerril |
| dc.subject.other.none.fl_str_mv |
Biomarcadores Crianças Inflamação Pneumonia Gravidade |
| topic |
Biomarcadores Crianças Inflamação Pneumonia Gravidade Biomarkers Children Inflammation Pneumonia Severity |
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Biomarkers Children Inflammation Pneumonia Severity |
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C.D.F. is supported by scholarship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.B.A. and P.M. receive a fellowship from the Fundação de Amparo à Pesquisa da Bahia (FAPESB). M.Cl.M.C. and C.L.V. are supported by CNPq (Brazilian National Council for Scientific and Technological Development). M.Ca.M.C. receives a scholarship from the Faculdade de Tecnologia e Ciências (FTC). B.B.A. and K.F. are supported by the intramural research program of FIOCRUZ. B.B.A. receives a senior fellowship from CNPq. |
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2019 |
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2019 |
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2020-01-28T14:35:29Z |
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FERNANDES, Catarina D. et al. Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, p. 1-13, 2019. |
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https://arca.fiocruz.br/handle/icict/39558 |
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2328-8957 |
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10.1093/ofid/ofz520 |
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FERNANDES, Catarina D. et al. Host Inflammatory Biomarkers of Disease Severity in Pediatric Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Open Forum Infectious Diseases, p. 1-13, 2019. 2328-8957 10.1093/ofid/ofz520 |
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