Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

Bibliographic Details
Main Author: Belo, Vinícius Silva
Publication Date: 2013
Other Authors: Werneck, Guilherme Loureiro, Barbosa, David Soeiro, Simões, Taynãna César, Nascimento, Bruno Warlley Leandro, Silva, Eduardo Sérgio da, Struchiner, Claudio José
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0002182
Download full: https://arca.fiocruz.br/handle/icict/71217
Summary: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.
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spelling Belo, Vinícius SilvaWerneck, Guilherme LoureiroBarbosa, David SoeiroSimões, Taynãna CésarNascimento, Bruno Warlley LeandroSilva, Eduardo Sérgio daStruchiner, Claudio José2025-08-01T19:27:51Z2013BELO, Vinícius Silva et al. Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis. PLOS Neglected Tropical Diseases, v. 7, n. 4, p. 1-12, Apr. 2013.1935-2735https://arca.fiocruz.br/handle/icict/7121710.1371/journal.pntd.0002182engPublic Library of ScienceDogsLeishmaniasisMetaanalysisKala-azarEpidemiologyMedical risk factorsSerologyFactors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Departamento de Epidemiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Centro de Referência Nacional e Internacional Para Flebotomíneos. Belo Horizonte, MG, Brasil.Universidade Federal de São João del Rei. Divinópolis, MG, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.Background: Still today, more than 30 years after the beginning of the process of visceral leishmaniasis’ urbanization, there is little knowledge about the risk factors for its occurrence, despite their relevance to the control and understanding of disease dynamics. The present study is the first systematic review with meta-analysis about factors associated with Leishmania infantum infection in humans in the Americas. Methods and Findings: After searching different databases, consultations to the reference lists of articles and to experts in the field, 51 studies were reviewed. Theoretical discussions or meta-analysis of p-values or of effect sizes were used to pool information about each variable. The Q test and the I2 statistic were used to assess heterogeneities among the studies. Male sex was associated with visceral leishmaniasis in studies which used the leishmanin skin test for diagnosis and in those where the outcome was the clinical disease; the opposite occurred when serological diagnosis was applied. Younger individuals were less frequently infected than adults, but were more prone to illness. Although with different levels of evidence and of heterogeneity, the presence of dogs at home, higher dog seropositivity in nearby areas, lower socioeconomic status and highly vegetated areas were associated with L. infantum infection. This was not noticed for the presence of chickens in the house and with nutritional status. Susceptibilities to bias and limitations in the analysis and in the description of results were often identified in the studies analyzed. Conclusions: Results showed the existence of consistent patterns for some of the factors analyzed and should be taken into account in developing more effective and well-targeted control measures. Studies must be conducted in new areas of the continent, with improved methodological quality and prioritizing the investigation of the patterns identified and their causes, as well as variables for which knowledge is poor.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/1713fadc-5f34-4527-8a12-b907e2d9ef70/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALFactors associated with visceral leishmaniasis in the.pdfFactors associated with visceral leishmaniasis in the.pdfapplication/pdf2275784https://arca.fiocruz.br/bitstreams/3c7ef5ea-4ae8-4c68-96b1-56f5882f5c11/download7f9f0d368a8277cc4a6588f31cadec73MD52trueAnonymousREADTEXTFactors associated with visceral leishmaniasis in the.pdf.txtFactors associated with visceral leishmaniasis in the.pdf.txtExtracted texttext/plain77450https://arca.fiocruz.br/bitstreams/99dcabf0-4ab5-4f00-9526-eb5b50f1b13d/downloadabd8711f8f1ca8163d1b6dd831144773MD53falseAnonymousREADTHUMBNAILFactors associated with visceral leishmaniasis in the.pdf.jpgFactors associated with visceral leishmaniasis in the.pdf.jpgGenerated Thumbnailimage/jpeg6459https://arca.fiocruz.br/bitstreams/47bc9c4f-cd15-4e3a-886c-4f96ddfc925c/download197794c1913c065403a356e558188d22MD54falseAnonymousREADicict/712172025-08-01 19:49:41.006open.accessoai:arca.fiocruz.br:icict/71217https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-08-01T22:49:41Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
title Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
spellingShingle Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
Belo, Vinícius Silva
Dogs
Leishmaniasis
Metaanalysis
Kala-azar
Epidemiology
Medical risk factors
Serology
title_short Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
title_full Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
title_fullStr Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
title_full_unstemmed Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
title_sort Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis
author Belo, Vinícius Silva
author_facet Belo, Vinícius Silva
Werneck, Guilherme Loureiro
Barbosa, David Soeiro
Simões, Taynãna César
Nascimento, Bruno Warlley Leandro
Silva, Eduardo Sérgio da
Struchiner, Claudio José
author_role author
author2 Werneck, Guilherme Loureiro
Barbosa, David Soeiro
Simões, Taynãna César
Nascimento, Bruno Warlley Leandro
Silva, Eduardo Sérgio da
Struchiner, Claudio José
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Belo, Vinícius Silva
Werneck, Guilherme Loureiro
Barbosa, David Soeiro
Simões, Taynãna César
Nascimento, Bruno Warlley Leandro
Silva, Eduardo Sérgio da
Struchiner, Claudio José
dc.subject.other.none.fl_str_mv Dogs
Leishmaniasis
Metaanalysis
Kala-azar
Epidemiology
Medical risk factors
Serology
topic Dogs
Leishmaniasis
Metaanalysis
Kala-azar
Epidemiology
Medical risk factors
Serology
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Endemias Samuel Pessoa. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2025-08-01T19:27:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BELO, Vinícius Silva et al. Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis. PLOS Neglected Tropical Diseases, v. 7, n. 4, p. 1-12, Apr. 2013.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/71217
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0002182
identifier_str_mv BELO, Vinícius Silva et al. Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis. PLOS Neglected Tropical Diseases, v. 7, n. 4, p. 1-12, Apr. 2013.
1935-2735
10.1371/journal.pntd.0002182
url https://arca.fiocruz.br/handle/icict/71217
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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