ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis

Bibliographic Details
Main Author: Santana, Marina B.r. de
Publication Date: 2025
Other Authors: Miranda, Giulia O., Carvalho, Lucas P.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.ijid.2024.107315
Download full: https://arca.fiocruz.br/handle/icict/68070
Summary: National Institutes of Health.
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spelling Santana, Marina B.r. deMiranda, Giulia O.Carvalho, Lucas P.2025-01-13T18:36:15Z2025-01-13T18:36:15Z2025SANTANA, Marina B. R. de; MIRANDA, Giulia O.; CARVALHO, Lucas P. ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis. International Journal of Infectious Diseases, v. 151, p. 1-6, 2025.1878-3511https://arca.fiocruz.br/handle/icict/6807010.1016/j.ijid.2024.107315National Institutes of Health.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisas Clínicas. Salvador, BA Brasil / Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Ministério da Ciência, Tecnologia e Inovação. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Brasília, DF, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil.Leishmania spp. are intracellular protozoan parasites causative of visceral and cutaneous leishmaniasis. Recognized as a neglected tropical disease affecting millions of people around the world, this affliction represents a major public health problem. In Brazil, pentavalent antimony (SbV ), the main therapy used to treat all clinical forms of leishmaniasis, has become increasingly associated with treatment failure. Many factors can influence leishmaniasis treatment outcome, including low expression aquaglyceroporin by the parasite and high activity of the ATP-binding cassette (ABC) transporters, efflux pumps whose activity has been associated with drug resistance in a variety of diseases. Current evidence suggests that some ABC transporters (e.g., MRP1 and MDR1) play a role in drug resistance in leishmaniasis. One way to potentially overcome SbV resistance may be a combined therapeutic strategy involving anti-Leishmania drugs administered together with ABC transporter inhibitors; however, toxicity poses a major challenge to the adoption of this approach.engElsevierATP-binding cassette transporters and drug resistance in cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeishmaniaMDRABC InhibitorABC transporterDrug resistanceLeishmaniaTransportadores de Cassetes de Ligação de ATPResistência a Medicamentosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/b2d24420-6bc1-40f1-a86a-377b7ca11ff9/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALSantanna , M. B. R. ATP-binding cassette transports and drug.pdfSantanna , M. B. R. 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dc.title.none.fl_str_mv ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
title ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
spellingShingle ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
Santana, Marina B.r. de
Leishmania
MDR
ABC Inhibitor
ABC transporter
Drug resistance
Leishmania
Transportadores de Cassetes de Ligação de ATP
Resistência a Medicamentos
title_short ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
title_full ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
title_fullStr ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
title_full_unstemmed ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
title_sort ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis
author Santana, Marina B.r. de
author_facet Santana, Marina B.r. de
Miranda, Giulia O.
Carvalho, Lucas P.
author_role author
author2 Miranda, Giulia O.
Carvalho, Lucas P.
author2_role author
author
dc.contributor.author.fl_str_mv Santana, Marina B.r. de
Miranda, Giulia O.
Carvalho, Lucas P.
dc.subject.en.none.fl_str_mv Leishmania
MDR
ABC Inhibitor
ABC transporter
Drug resistance
topic Leishmania
MDR
ABC Inhibitor
ABC transporter
Drug resistance
Leishmania
Transportadores de Cassetes de Ligação de ATP
Resistência a Medicamentos
dc.subject.decs.none.fl_str_mv Leishmania
Transportadores de Cassetes de Ligação de ATP
Resistência a Medicamentos
description National Institutes of Health.
publishDate 2025
dc.date.accessioned.fl_str_mv 2025-01-13T18:36:15Z
dc.date.available.fl_str_mv 2025-01-13T18:36:15Z
dc.date.issued.fl_str_mv 2025
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTANA, Marina B. R. de; MIRANDA, Giulia O.; CARVALHO, Lucas P. ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis. International Journal of Infectious Diseases, v. 151, p. 1-6, 2025.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/68070
dc.identifier.issn.none.fl_str_mv 1878-3511
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2024.107315
identifier_str_mv SANTANA, Marina B. R. de; MIRANDA, Giulia O.; CARVALHO, Lucas P. ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis. International Journal of Infectious Diseases, v. 151, p. 1-6, 2025.
1878-3511
10.1016/j.ijid.2024.107315
url https://arca.fiocruz.br/handle/icict/68070
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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