CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

Detalhes bibliográficos
Autor(a) principal: Marino, A. P. M. P.
Data de Publicação: 2005
Outros Autores: Silva, A. A., Santos, P. V. A., Pinto, L. M. O., Gazinelli, R. T., Teixeira, M. M., Lannes-Vieira, Joseli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02762005000900015
Texto Completo: https://arca.fiocruz.br/handle/icict/33296
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.
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spelling Marino, A. P. M. P.Silva, A. A.Santos, P. V. A.Pinto, L. M. O.Gazinelli, R. T.Teixeira, M. M.Lannes-Vieira, Joseli2019-05-30T15:46:45Z2019-05-30T15:46:45Z2005MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.0074-0276https://arca.fiocruz.br/handle/icict/3329610.1590/S0074-027620050009000151678-8060engFiocruz/IOCTrypanosoma cruziMiocarditeQuimiocinas CCReceptores de quimiocinas CCTrypanosoma cruziMyocarditisCC-chemokinesCC-chemokine receptorsMet-RANTESCC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte. MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1α, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzielicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/37c4e4cd-4cd3-4cd5-acdb-cdb3b2013889/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALJoseliLannes_Vieira_etal_IOC_2005.pdfJoseliLannes_Vieira_etal_IOC_2005.pdfapplication/pdf35069https://arca.fiocruz.br/bitstreams/9f8ee15d-4f4a-4b7c-ba3d-fa1a92774915/downloadd10f2e72397da9340e1f3c5780b2681fMD52trueAnonymousREADTEXTJoseliLannes_Vieira_etal_IOC_2005.pdf.txtJoseliLannes_Vieira_etal_IOC_2005.pdf.txtExtracted texttext/plain24830https://arca.fiocruz.br/bitstreams/ed68bc3b-3531-4162-9737-f68f0b0b0be0/download19435ac99d951184c71dc6164263e04dMD57falseAnonymousREADTHUMBNAILJoseliLannes_Vieira_etal_IOC_2005.pdf.jpgJoseliLannes_Vieira_etal_IOC_2005.pdf.jpgGenerated Thumbnailimage/jpeg6279https://arca.fiocruz.br/bitstreams/54660383-1598-4f66-9502-49faa8cad4ba/downloadbefb5af0b9cb41a7f33e20a196bac051MD58falseAnonymousREADicict/332962025-07-31 13:22:19.071open.accessoai:arca.fiocruz.br:icict/33296https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-31T16:22:19Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
spellingShingle CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Marino, A. P. M. P.
Trypanosoma cruzi
Miocardite
Quimiocinas CC
Receptores de quimiocinas CC
Trypanosoma cruzi
Myocarditis
CC-chemokines
CC-chemokine receptors
Met-RANTES
title_short CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_full CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_fullStr CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_full_unstemmed CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
title_sort CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
author Marino, A. P. M. P.
author_facet Marino, A. P. M. P.
Silva, A. A.
Santos, P. V. A.
Pinto, L. M. O.
Gazinelli, R. T.
Teixeira, M. M.
Lannes-Vieira, Joseli
author_role author
author2 Silva, A. A.
Santos, P. V. A.
Pinto, L. M. O.
Gazinelli, R. T.
Teixeira, M. M.
Lannes-Vieira, Joseli
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marino, A. P. M. P.
Silva, A. A.
Santos, P. V. A.
Pinto, L. M. O.
Gazinelli, R. T.
Teixeira, M. M.
Lannes-Vieira, Joseli
dc.subject.other.none.fl_str_mv Trypanosoma cruzi
Miocardite
Quimiocinas CC
Receptores de quimiocinas CC
topic Trypanosoma cruzi
Miocardite
Quimiocinas CC
Receptores de quimiocinas CC
Trypanosoma cruzi
Myocarditis
CC-chemokines
CC-chemokine receptors
Met-RANTES
dc.subject.en.none.fl_str_mv Trypanosoma cruzi
Myocarditis
CC-chemokines
CC-chemokine receptors
Met-RANTES
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Autoimunidade e Imuno-regulação. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-05-30T15:46:45Z
dc.date.available.fl_str_mv 2019-05-30T15:46:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/33296
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762005000900015
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MARINO, A. P. M. P. et al. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p.93-96, 2005.
0074-0276
10.1590/S0074-02762005000900015
1678-8060
url https://arca.fiocruz.br/handle/icict/33296
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/IOC
publisher.none.fl_str_mv Fiocruz/IOC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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