Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.

Guimarães, Adriana Gibara; Oliveira, Marlange Almeida; Alves, Rafael dos Santos; Menezes, Paula dos Passos; Serafini, Mairim Russo; Araújo, Adriano Antunes de Souza; Bezerra, Daniel Pereira; Quintans Júnior, Lucindo José

Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.

Bibliographic Details
Main Author:	Guimarães, Adriana Gibara
Publication Date:	2015
Other Authors:	Oliveira, Marlange Almeida, Alves, Rafael dos Santos, Menezes, Paula dos Passos, Serafini, Mairim Russo, Araújo, Adriano Antunes de Souza, Bezerra, Daniel Pereira, Quintans Júnior, Lucindo José
Format:	Article
Language:	eng
Source:	Repositório Institucional da FIOCRUZ (ARCA)
DOI:	dx.doi.org/10.1016/j.cbi.2014.12.020
Download full:	https://arca.fiocruz.br/handle/icict/13431
Summary:	Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil

Item metadata

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Guimarães, Adriana GibaraOliveira, Marlange AlmeidaAlves, Rafael dos SantosMenezes, Paula dos PassosSerafini, Mairim RussoAraújo, Adriano Antunes de SouzaBezerra, Daniel PereiraQuintans Júnior, Lucindo José2016-03-31T19:14:21Z2016-03-31T19:14:21Z2015GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015.0009-2797https://arca.fiocruz.br/handle/icict/13431dx.doi.org/10.1016/j.cbi.2014.12.020engElsevierEncapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Sergipe. Department of Health Education. Lagarto, SE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFederal University of Sergipe. Department of Pharmacy. Lagarto, São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, BrasilFederal University of Sergipe. Department of Health Education. Lagarto, SE, BrasilCancer pain is a major public health problem worldwide due to the strong impact on the quality of life of patients and side effects of the existing therapeutic options. Monoterpenes, as carvacrol (CARV), have been extensively studied about their therapeutic properties, especially their importance in the control of painful conditions and inflammation, which can be improved through the use of inclusion complexes of b-cyclodextrin (b-CD). We evaluated the effect of encapsulation of CARV in b-CD (CARV/b-CD) on the nociception induced by tumor cells (Sarcoma 180) in rodents. Inclusion complexes were prepared in two different procedures and characterized through thermal analysis and scanning electron microscopy. CARV/b-CD complex was administered (50 mg/kg, p.o.) in mice with tumor on the hind paw and was able to reduce the hyperalgesia (von Frey) during 24 h, unlike the free CARV (100 mg/kg, p.o.), which promoted effects until 9 h. Administration on alternate days of complex of CARV/b-CD (12.5–50 mg/kg, p.o.) reduced hyperalgesia, as well as spontaneous and palpation-induced nociception. However, pure CARV (50 mg/kg) did not cause significant changes in nociceptive responses. Together, these results produced evidence that the encapsulation of carvacrol in b-cyclodextrin can be useful for the development of new options for pain managementCancer painHyperalgesiaNociceptionMonoterpeneCarvacrolb-Cyclodextrininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/ec4ba85a-742e-4ccb-b785-f09d983c103f/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALGuimarães AG. Encapsulation of carvacrol....pdfGuimarães AG. Encapsulation of carvacrol....pdfapplication/pdf1280691https://arca.fiocruz.br/bitstreams/64346ab9-1e2d-4767-a5c7-8c67486eef7f/download1b25210e998e9c85c66ad6d7122682c9MD52trueAnonymousREADTEXTGuimarães AG. Encapsulation of carvacrol....pdf.txtGuimarães AG. 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dc.title.none.fl_str_mv	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
spellingShingle	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Guimarães, Adriana Gibara Cancer pain Hyperalgesia Nociception Monoterpene Carvacrol b-Cyclodextrin
title_short	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_full	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_fullStr	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_full_unstemmed	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
title_sort	Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
author	Guimarães, Adriana Gibara
author_facet	Guimarães, Adriana Gibara Oliveira, Marlange Almeida Alves, Rafael dos Santos Menezes, Paula dos Passos Serafini, Mairim Russo Araújo, Adriano Antunes de Souza Bezerra, Daniel Pereira Quintans Júnior, Lucindo José
author_role	author
author2	Oliveira, Marlange Almeida Alves, Rafael dos Santos Menezes, Paula dos Passos Serafini, Mairim Russo Araújo, Adriano Antunes de Souza Bezerra, Daniel Pereira Quintans Júnior, Lucindo José
author2_role	author author author author author author author
dc.contributor.author.fl_str_mv	Guimarães, Adriana Gibara Oliveira, Marlange Almeida Alves, Rafael dos Santos Menezes, Paula dos Passos Serafini, Mairim Russo Araújo, Adriano Antunes de Souza Bezerra, Daniel Pereira Quintans Júnior, Lucindo José
dc.subject.en.none.fl_str_mv	Cancer pain Hyperalgesia Nociception Monoterpene Carvacrol b-Cyclodextrin
topic	Cancer pain Hyperalgesia Nociception Monoterpene Carvacrol b-Cyclodextrin
description	Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil
publishDate	2015
dc.date.issued.fl_str_mv	2015
dc.date.accessioned.fl_str_mv	2016-03-31T19:14:21Z
dc.date.available.fl_str_mv	2016-03-31T19:14:21Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015.
dc.identifier.uri.fl_str_mv	https://arca.fiocruz.br/handle/icict/13431
dc.identifier.issn.none.fl_str_mv	0009-2797
dc.identifier.doi.none.fl_str_mv	dx.doi.org/10.1016/j.cbi.2014.12.020
identifier_str_mv	GUIMARÃES, A. G. et al. Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols. Chemico-Biological Interactions, v. 227, p. 69-76, 2015. 0009-2797 dx.doi.org/10.1016/j.cbi.2014.12.020
url	https://arca.fiocruz.br/handle/icict/13431
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with ß-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.

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