Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil

Bibliographic Details
Main Author: Freitas, Bruno de Paula
Publication Date: 2016
Other Authors: Dias, João Rafael de Oliveira, Prazeres, Juliana, Sacramento, Gielson Almeida, Ko, Albert Icksang, Maia, Maurício, Belfort Junior, Rubens
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: :10.1001/jamaophthalmol.2016.0267
Download full: https://arca.fiocruz.br/handle/icict/13025
Summary: Hospital Geral Roberto Santos. Department of Ophthalmology. Salvador, BA, Brasil
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spelling Freitas, Bruno de PaulaDias, João Rafael de OliveiraPrazeres, JulianaSacramento, Gielson AlmeidaKo, Albert IcksangMaia, MaurícioBelfort Junior, Rubens2016-03-04T17:03:30Z2016-03-04T17:03:30Z2016FREITAS, B. P. et al. Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil. JAMA Ophthalmology, feb-9, 20162168-6165https://arca.fiocruz.br/handle/icict/13025:10.1001/jamaophthalmol.2016.0267engAmerican Medical Association (AMA)Microcefaliarecém-nascidosZika virusVírusInfecção congênitaVisãoNerco ópticoDegeneração macularOcular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Geral Roberto Santos. Department of Ophthalmology. Salvador, BA, BrasilFederal University of São Paulo. Paulista Medical School. Vision Institute. Department of Ophthalmology, São Paulo, SP, BrasilFederal University of São Paulo. Paulista Medical School. Vision Institute. Department of Ophthalmology, São Paulo, SP, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, ConnecticutFederal University of São Paulo. Paulista Medical School. Vision Institute. Department of Ophthalmology, São Paulo, SP, BrasilFederal University of São Paulo. Paulista Medical School. Vision Institute. Department of Ophthalmology, São Paulo, SP, BrasilIMPORTANCE The Zika virus (ZIKV) has rapidly reached epidemic proportions, especially in northeastern Brazil, and has rapidly spread to other parts of the Americas. A recent increase in the prevalence of microcephaly in newborn infants and vision-threatening findings in these infants is likely associated with the rapid spread of ZIKV. OBJECTIVE To evaluate the ocular findings in infants with microcephaly associated with presumed intrauterine ZIKV infection in Salvador, Bahia, Brazil. DESIGN, SETTING, AND PARTICIPANTS Case series at a tertiary hospital. Twenty-nine infants with microcephaly (defined by a cephalic circumference of 32 cm) with a presumed diagnosis of congenital ZIKV were recruited through an active search and referrals from other hospitals and health unities. The study was conducted between December 1 and December 21, 2015. INTERVENTIONS All infants and mothers underwent systemic and ophthalmic examinations from December 1 through December 21, 2015, in the Roberto Santos General Hospital, Salvador, Brazil. Anterior segment and retinal, choroidal, and optic nerve abnormalities were documented using a wide-field digital imaging system. The differential diagnosis included toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, syphilis, and human immunodeficiency virus, which were ruled out through serologic and clinical examinations. MAIN OUTCOMES AND MEASURES Ocular abnormalities associated with ZIKV. RESULTS Twenty-three of 29 mothers (79.3%) reported suspected ZIKV infection signs and symptoms during pregnancy, 18 in the first trimester, 4 in the second trimester, and 1 in the third trimester. Of the 29 infants (58 eyes) examined (18 [62.1%] female), ocular abnormalities were present in 17 eyes (29.3%) of 10 children (34.5%). Bilateral findings were found in 7 of 10 patients presenting with ocular lesions, the most common of which were focal pigment mottling of the retina and chorioretinal atrophy in 11 of the 17 eyes with abnormalities (64.7%), followed by optic nerve abnormalities in 8 eyes (47.1%), bilateral iris coloboma in 1 patient (2 eyes [11.8%]), and lens subluxation in 1 eye (5.9% CONCLUSIONS AND RELEVANCE Congenital infection due to presumed ZIKV exposure is associated with vision-threatening findings, which include bilateral macular and perimacular lesions as well as optic nerve abnormalities in most cases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/06b34402-b04b-47bc-b4ec-319c28db6a34/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALFREITAS BP Ocular find....pdfFREITAS BP Ocular find....pdfapplication/pdf553660https://arca.fiocruz.br/bitstreams/fee6719d-eead-45a6-b2dd-cce97ff10e06/download19c134ecad7140a07513fcc6f4779e6aMD52trueAnonymousREADTEXTFREITAS BP Ocular find....pdf.txtFREITAS BP Ocular find....pdf.txtExtracted texttext/plain37938https://arca.fiocruz.br/bitstreams/14d5e259-1e00-4123-a1b7-7a8770d7b7ef/downloadd5ac323b08ce31ce2297e9d4b960252cMD56falseAnonymousREADTHUMBNAILFREITAS BP Ocular find....pdf.jpgFREITAS BP Ocular find....pdf.jpgGenerated Thumbnailimage/jpeg4760https://arca.fiocruz.br/bitstreams/64c20150-5c11-42c4-865d-4f6b42384da9/downloadaaf8504eb390e554f8b2dd84b4e494efMD57falseAnonymousREADicict/130252025-07-29 19:32:59.028open.accessoai:arca.fiocruz.br:icict/13025https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:32:59Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
title Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
spellingShingle Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
Freitas, Bruno de Paula
Microcefalia
recém-nascidos
Zika virus
Vírus
Infecção congênita
Visão
Nerco óptico
Degeneração macular
title_short Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
title_full Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
title_fullStr Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
title_full_unstemmed Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
title_sort Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil
author Freitas, Bruno de Paula
author_facet Freitas, Bruno de Paula
Dias, João Rafael de Oliveira
Prazeres, Juliana
Sacramento, Gielson Almeida
Ko, Albert Icksang
Maia, Maurício
Belfort Junior, Rubens
author_role author
author2 Dias, João Rafael de Oliveira
Prazeres, Juliana
Sacramento, Gielson Almeida
Ko, Albert Icksang
Maia, Maurício
Belfort Junior, Rubens
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Bruno de Paula
Dias, João Rafael de Oliveira
Prazeres, Juliana
Sacramento, Gielson Almeida
Ko, Albert Icksang
Maia, Maurício
Belfort Junior, Rubens
dc.subject.other.none.fl_str_mv Microcefalia
recém-nascidos
Zika virus
Vírus
Infecção congênita
Visão
Nerco óptico
Degeneração macular
topic Microcefalia
recém-nascidos
Zika virus
Vírus
Infecção congênita
Visão
Nerco óptico
Degeneração macular
description Hospital Geral Roberto Santos. Department of Ophthalmology. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-03-04T17:03:30Z
dc.date.available.fl_str_mv 2016-03-04T17:03:30Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, B. P. et al. Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil. JAMA Ophthalmology, feb-9, 2016
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/13025
dc.identifier.issn.none.fl_str_mv 2168-6165
dc.identifier.doi.none.fl_str_mv :10.1001/jamaophthalmol.2016.0267
identifier_str_mv FREITAS, B. P. et al. Ocular findings in infants with microcephaly associated with presumed Zika Virus congenital infection in Salvador, Brazil. JAMA Ophthalmology, feb-9, 2016
2168-6165
:10.1001/jamaophthalmol.2016.0267
url https://arca.fiocruz.br/handle/icict/13025
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Medical Association (AMA)
publisher.none.fl_str_mv American Medical Association (AMA)
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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