Herpesvirus and neurological manifestations in patients with severe coronavirus disease
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1186/s12985-022-01828-9 |
| Download full: | https://arca.fiocruz.br/handle/icict/54561 |
Summary: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. |
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Carneiro, Vanessa Cristine deAlves‑leon, Soniza VieiraSarmento, Dmitry José de SantanaCoelho, Wagner Luis da Costa Nunes PimentelMoreira, Otacilio da CruzLemos, Andreza SalvioRamos, Carlos Henrique FerreiraRamos Filho, Carlos Henrique FerreiraMarques, Carla Augusta BarretoGonçalves, João Paulo da CostaLeon, Luciane Almeida AmadoPaula, Vanessa Salete de2022-08-10T13:28:12Z2022-08-10T13:28:12Z2022CARNEIRO, Vanessa Cristine de Souza et al. Herpesvirus and neurological manifestations in patients with severe coronavirus disease. Virology Journal, v. 19, n. 101, p. 1 - 9, 2022.1743-422Xhttps://arca.fiocruz.br/handle/icict/5456110.1186/s12985-022-01828-9engBMCInfecção por SARS-CoV-2Manifestações neurológicasHerpesvírusSARS-CoV-2 infectionHerpesvirusNeurological manifestationsHerpesvirus and neurological manifestations in patients with severe coronavirus diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Neurologia/Referência e Centro de Pesquisa em Esclerose Múltipla e Outras Doenças do Sistema Nervoso Central Doenças Inflamatórias Desmielinizantes Idiopáticas do Sistema. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Universidade Estadual da Paraíba. Escola de Odontologia. Departamento de Diagnóstico Oral. Araruna, PB, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Endemias. Plataforma de PCR em tempo real RPT09A. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro / UNIRIO. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro / UNIRIO. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro / UNIRIO. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro / UNIRIO. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Neurologia/Referência e Centro de Pesquisa em Esclerose Múltipla e Outras Doenças do Sistema Nervoso Central Doenças Inflamatórias Desmielinizantes Idiopáticas do Sistema. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro / UNIRIO. Instituto Biomédico. Laboratório de Neurociências Translacionais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms. Methods: We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method. Results: Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034). Conclusions: The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/621e4ac6-2a54-441f-bc8e-b325ad6e2ee1/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALVanessaCristine_VanessadePaula_etal_IOC_2002.pdfVanessaCristine_VanessadePaula_etal_IOC_2002.pdfapplication/pdf841041https://arca.fiocruz.br/bitstreams/20f1bd90-699f-41fd-8219-5ee74f429047/download6e1aa0430b2656a882bd9a2a4cbd26eaMD52trueAnonymousREADTEXTVanessaCristine_VanessadePaula_etal_IOC_2002.pdf.txtVanessaCristine_VanessadePaula_etal_IOC_2002.pdf.txtExtracted texttext/plain46453https://arca.fiocruz.br/bitstreams/acadf305-4234-45aa-9f34-127d8f8a32dd/download5a07f5a2f9abf0df72a015fbdeb56ab8MD57falseAnonymousREADTHUMBNAILVanessaCristine_VanessadePaula_etal_IOC_2002.pdf.jpgVanessaCristine_VanessadePaula_etal_IOC_2002.pdf.jpgGenerated Thumbnailimage/jpeg6070https://arca.fiocruz.br/bitstreams/f2bde8e7-cc0f-4aa2-b2fc-2405e82eada9/downloadf6c40e98ba262d36203b90e8dd728e8eMD58falseAnonymousREADicict/545612025-07-29 19:27:19.208open.accessoai:arca.fiocruz.br:icict/54561https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:27:19Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| spellingShingle |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease Carneiro, Vanessa Cristine de Infecção por SARS-CoV-2 Manifestações neurológicas Herpesvírus SARS-CoV-2 infection Herpesvirus Neurological manifestations |
| title_short |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_full |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_fullStr |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_full_unstemmed |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_sort |
Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| author |
Carneiro, Vanessa Cristine de |
| author_facet |
Carneiro, Vanessa Cristine de Alves‑leon, Soniza Vieira Sarmento, Dmitry José de Santana Coelho, Wagner Luis da Costa Nunes Pimentel Moreira, Otacilio da Cruz Lemos, Andreza Salvio Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Marques, Carla Augusta Barreto Gonçalves, João Paulo da Costa Leon, Luciane Almeida Amado Paula, Vanessa Salete de |
| author_role |
author |
| author2 |
Alves‑leon, Soniza Vieira Sarmento, Dmitry José de Santana Coelho, Wagner Luis da Costa Nunes Pimentel Moreira, Otacilio da Cruz Lemos, Andreza Salvio Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Marques, Carla Augusta Barreto Gonçalves, João Paulo da Costa Leon, Luciane Almeida Amado Paula, Vanessa Salete de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carneiro, Vanessa Cristine de Alves‑leon, Soniza Vieira Sarmento, Dmitry José de Santana Coelho, Wagner Luis da Costa Nunes Pimentel Moreira, Otacilio da Cruz Lemos, Andreza Salvio Ramos, Carlos Henrique Ferreira Ramos Filho, Carlos Henrique Ferreira Marques, Carla Augusta Barreto Gonçalves, João Paulo da Costa Leon, Luciane Almeida Amado Paula, Vanessa Salete de |
| dc.subject.other.none.fl_str_mv |
Infecção por SARS-CoV-2 Manifestações neurológicas Herpesvírus |
| topic |
Infecção por SARS-CoV-2 Manifestações neurológicas Herpesvírus SARS-CoV-2 infection Herpesvirus Neurological manifestations |
| dc.subject.en.none.fl_str_mv |
SARS-CoV-2 infection Herpesvirus Neurological manifestations |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. |
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2022 |
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2022-08-10T13:28:12Z |
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2022-08-10T13:28:12Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CARNEIRO, Vanessa Cristine de Souza et al. Herpesvirus and neurological manifestations in patients with severe coronavirus disease. Virology Journal, v. 19, n. 101, p. 1 - 9, 2022. |
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https://arca.fiocruz.br/handle/icict/54561 |
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1743-422X |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12985-022-01828-9 |
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CARNEIRO, Vanessa Cristine de Souza et al. Herpesvirus and neurological manifestations in patients with severe coronavirus disease. Virology Journal, v. 19, n. 101, p. 1 - 9, 2022. 1743-422X 10.1186/s12985-022-01828-9 |
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BMC |
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