Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study

Bibliographic Details
Main Author: Puga, Marcelo Lourencini
Publication Date: 2022
Other Authors: Menegueti, Mayra Gonçalves, Silvestrini, Marina Malheiros Araújo, Santos, Lorena Júnia de Souza, Nogueira, Raquel Ferreira, Basile Filho, Aníbal, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Martins, Maria Auxiliadora
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://arca.fiocruz.br/handle/icict/56562
Summary: Division of Intensive Care. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil
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spelling Puga, Marcelo LourenciniMenegueti, Mayra GonçalvesSilvestrini, Marina Malheiros AraújoSantos, Lorena Júnia de SouzaNogueira, Raquel FerreiraBasile Filho, AníbalCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisMartins, Maria Auxiliadora2023-01-23T18:24:55Z2023-01-23T18:24:55Z2022PUGA, Marcelo Lourencini et al. Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study. Biomed Pharmacother., v. 146, 112490, 2022. doi: 10.1016/j.biopha.2021.112490.0753-3322https://arca.fiocruz.br/handle/icict/56562engEditions Scientifiques ElsevierPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDivision of Intensive Care. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, BrazilRibeirão Preto Nursing School. University of São Paulo. Ribeirão Preto, SP, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilBeckman Coulter. BrazilDivision of Intensive Care. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilDivision of Intensive Care. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, BrazilSepsis remains one of the main causes of death in intensive care unit (ICU) worldwide, despite all technological and scientific advances. Microvesicles (MV) have become promising biomarkers for quick and accurate monitoring of several illnesses. The aim of this pilot study was to characterize and evaluate the performance of MV as biomarker of clinical outcome in septic and trauma patients. For this purpose, 39 subjects, both genders, aging from 18 to 85 years were included in three groups referred as Sepsis, Trauma and Healthy Control. Kinetic analysis of MV was carried out at four consecutive time points: admission (baseline)/T1, 24 h/T2, 72 h/T3 and outcome/T4 of discharge or death. At admission, an overall increase in total MV (Annexin V+) was observed in Sepsis.MV CD14+ (monocytes) was a putative biomarker to identify trauma patients, while MV CD3+ (T-cells) and CD41+ (platelets) were qualified to discriminated Trauma from Sepsis. Sepsis (Death) presented an increase in MV Annexin V+, CD45+, CD16+, CD14+, and CD41+ in comparison to Sepsis (Discharge). Moreover, Trauma (Death) presented an increase of MV CD3+ and CD235+ as compared to Trauma (Discharge). Analysing the ROC curve of specific MV evaluated according to performance, an accuracy of 100% was found to segregate the outcome in sepsis, and 95% in trauma. Our findings suggest that MV might be useful as a potential role in discriminating outcome in patients with sepsis/septic shock and trauma with high accuracy. However, further studies with a larger number of participants will be necessary to validate our findings.MicrovesiclesSepsisSeptic shockBiomarkersTraumainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/3b8f91e8-6b06-4d07-a035-9a454cc7fc5f/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdfPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdfapplication/pdf4982912https://arca.fiocruz.br/bitstreams/8d8a40bf-b541-4eb9-9eef-a9d4f5d2c58d/download2f4d683129a4346debb1efb2af2d6642MD52trueAnonymousREADTEXTPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdf.txtPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdf.txtExtracted texttext/plain22https://arca.fiocruz.br/bitstreams/1ec0ff50-9d52-4cae-9b3a-3b4b3893617e/download6cccda74febad7705949cb89ee2669ddMD55falseAnonymousREADTHUMBNAILPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdf.jpgPerformance of microvesicles as biomarkers of clinical outcome in sepsis and trauma.pdf.jpgGenerated Thumbnailimage/jpeg5256https://arca.fiocruz.br/bitstreams/9b606e11-d28b-4df7-a82e-dfc5b18474c4/download58351de4e931a0dec28ae3570fdfb910MD56falseAnonymousREADicict/565622025-07-30 01:10:33.426open.accessoai:arca.fiocruz.br:icict/56562https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:10:33Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
title Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
spellingShingle Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
Puga, Marcelo Lourencini
Microvesicles
Sepsis
Septic shock
Biomarkers
Trauma
title_short Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
title_full Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
title_fullStr Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
title_full_unstemmed Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
title_sort Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study
author Puga, Marcelo Lourencini
author_facet Puga, Marcelo Lourencini
Menegueti, Mayra Gonçalves
Silvestrini, Marina Malheiros Araújo
Santos, Lorena Júnia de Souza
Nogueira, Raquel Ferreira
Basile Filho, Aníbal
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
author_role author
author2 Menegueti, Mayra Gonçalves
Silvestrini, Marina Malheiros Araújo
Santos, Lorena Júnia de Souza
Nogueira, Raquel Ferreira
Basile Filho, Aníbal
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Puga, Marcelo Lourencini
Menegueti, Mayra Gonçalves
Silvestrini, Marina Malheiros Araújo
Santos, Lorena Júnia de Souza
Nogueira, Raquel Ferreira
Basile Filho, Aníbal
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Martins, Maria Auxiliadora
dc.subject.en.none.fl_str_mv Microvesicles
Sepsis
Septic shock
Biomarkers
Trauma
topic Microvesicles
Sepsis
Septic shock
Biomarkers
Trauma
description Division of Intensive Care. Department of Surgery and Anatomy. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-23T18:24:55Z
dc.date.available.fl_str_mv 2023-01-23T18:24:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PUGA, Marcelo Lourencini et al. Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study. Biomed Pharmacother., v. 146, 112490, 2022. doi: 10.1016/j.biopha.2021.112490.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/56562
dc.identifier.issn.none.fl_str_mv 0753-3322
identifier_str_mv PUGA, Marcelo Lourencini et al. Performance of microvesicles as biomarkers of clinical outcome in sepsis and trauma: A pilot study. Biomed Pharmacother., v. 146, 112490, 2022. doi: 10.1016/j.biopha.2021.112490.
0753-3322
url https://arca.fiocruz.br/handle/icict/56562
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Editions Scientifiques Elsevier
publisher.none.fl_str_mv Editions Scientifiques Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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