Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pone.0267472 |
| Download full: | https://arca.fiocruz.br/handle/icict/54586 |
Summary: | Produção científica do Laboratório de Hanseníase. |
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Mabunda, NédioAugusto, OrvalhoZicai, Ana FloraDuajá, AnaOficiano, SandraIsmael, NaliaVubil, AdolfoMussá, TufáriaMoraes, Milton OzórioJani, Ilesh2022-08-11T12:03:10Z2022-08-11T12:03:10Z2022MABUNDA, Nédio et al. Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique. PLoS ONE, v. 17, n. 4, p. 1-12, 28 Apr. 2022.1932-6203https://arca.fiocruz.br/handle/icict/5458610.1371/journal.pone.02674721932-6203Produção científica do Laboratório de Hanseníase.Instituto Nacional de Saúde. Marracuene, Mozambique / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Eduardo Mondlane. Faculdade de Medicina. Maputo, Mozambique.Instituto Nacional de Saúde. Marracuene, Mozambique.Instituto Nacional de Saúde. Marracuene, Mozambique / Hospital Central da Beira. Sofala, Mozambique.Hospital Central de Maputo. Maputo, Mozambique.Instituto Nacional de Saúde. Marracuene, Mozambique.Instituto Nacional de Saúde. Marracuene, Mozambique.Universidade Eduardo Mondlane. Faculdade de Medicina. Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Saúde. Marracuene, Mozambique.Background: Although blood transfusion is an intervention that saves lives, it poses significant risks to the blood receivers, including the transmission of bloodborne pathogens. We aimed at determining the prevalence of Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), and Hepatitis C virus (HCV) in candidates approved for blood donation, and in samples considered to be negative in reference blood banks in Mozambique. Methods: A cross-sectional study was performed between November 2014 and October 2015 in Maputo and Beira cities. Demographic information was obtained from all consenting blood donors using a structured questionnaire. Plasma samples were screened for HIVAb/Ag combinations, HBsAg and Anti-HCV. Blood donors considered to be negative by serological testing were re-tested in pools of six plasma samples using nucleic acid testing (NAT). Results: Most blood donors were male 2,320 (83.4%) with an age range of 18 to 34 years. The overall seroprevalence of HIV, HBV and HCV infections among blood donors approved for donation was 4.6% (127; 95% CI 3.8–5.4), 4.5% (124; 95% CI 3.7–5.3) and 0.4% (11; 95% CI 0.2–0.7), respectively. The overall frequency by NAT of HIV RNA, HBV DNA, and HCV RNA in serologically negative blood donor samples was 2.6 per 1000 blood donors (7; 95% CI 1.1–5.4); 12.5 per 1000 blood donors (33; 95% CI 8.6–17.5) and 2.6 per 1000 blood donors (6; 95% CI 1.0–5.7), respectively. Conclusion: Our results show high seroprevalence of HIV and HBV infections in blood donors approved for donation, and high frequency of molecular biomarkers of HIV, HBV, and HCV in blood considered to be safe. These results suggest the need for a new blood screening policy in Mozambique, including the use of NAT to detect infectious blood donations during the immunologically negative window.engPublic Library of ScienceNucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambiqueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBlood donorsHIVVirus testingSerologyHepatitis B virusMedical risk factorsBlood banksMozambiqueinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/b9df632e-72e0-43ae-b798-db79e354b894/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALMiltonMoraes_NedioMabunda_etal_IOC_2022.pdfMiltonMoraes_NedioMabunda_etal_IOC_2022.pdfapplication/pdf645077https://arca.fiocruz.br/bitstreams/af7c19c8-3ba5-4e6e-bcb5-9c5bc0e7ea10/download9f390a27c7e066784ac2070c211399eaMD52trueAnonymousREADTHUMBNAILcapa_Nedio_Mabunda_etal_IOC_2022.jpgcapa_Nedio_Mabunda_etal_IOC_2022.jpgCapaimage/jpeg2085610https://arca.fiocruz.br/bitstreams/d7b50ffc-3f84-4918-8d5f-8dc24c63a8a9/download3d91681c118f124c62b93cb795873861MD53falseAnonymousREADMiltonMoraes_NedioMabunda_etal_IOC_2022.pdf.jpgMiltonMoraes_NedioMabunda_etal_IOC_2022.pdf.jpgGenerated Thumbnailimage/jpeg5746https://arca.fiocruz.br/bitstreams/456a3b84-c288-4e9f-bbbe-e4a8b5046c38/downloadc5a1df286acb7a23b2bc860cf3dd8a6aMD57falseAnonymousREADTEXTMiltonMoraes_NedioMabunda_etal_IOC_2022.pdf.txtMiltonMoraes_NedioMabunda_etal_IOC_2022.pdf.txtExtracted texttext/plain44465https://arca.fiocruz.br/bitstreams/0bd4e7d8-0dbf-4632-941b-a2637a420ac2/downloada4bbbe1ad65b88e49506812e7ec862adMD56falseAnonymousREADicict/545862025-07-30 02:39:02.447open.accessoai:arca.fiocruz.br:icict/54586https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T05:39:02Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| title |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| spellingShingle |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique Mabunda, Nédio Blood donors HIV Virus testing Serology Hepatitis B virus Medical risk factors Blood banks Mozambique |
| title_short |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| title_full |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| title_fullStr |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| title_full_unstemmed |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| title_sort |
Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique |
| author |
Mabunda, Nédio |
| author_facet |
Mabunda, Nédio Augusto, Orvalho Zicai, Ana Flora Duajá, Ana Oficiano, Sandra Ismael, Nalia Vubil, Adolfo Mussá, Tufária Moraes, Milton Ozório Jani, Ilesh |
| author_role |
author |
| author2 |
Augusto, Orvalho Zicai, Ana Flora Duajá, Ana Oficiano, Sandra Ismael, Nalia Vubil, Adolfo Mussá, Tufária Moraes, Milton Ozório Jani, Ilesh |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mabunda, Nédio Augusto, Orvalho Zicai, Ana Flora Duajá, Ana Oficiano, Sandra Ismael, Nalia Vubil, Adolfo Mussá, Tufária Moraes, Milton Ozório Jani, Ilesh |
| dc.subject.en.none.fl_str_mv |
Blood donors HIV Virus testing Serology Hepatitis B virus Medical risk factors Blood banks Mozambique |
| topic |
Blood donors HIV Virus testing Serology Hepatitis B virus Medical risk factors Blood banks Mozambique |
| description |
Produção científica do Laboratório de Hanseníase. |
| publishDate |
2022 |
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2022-08-11T12:03:10Z |
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2022-08-11T12:03:10Z |
| dc.date.issued.fl_str_mv |
2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MABUNDA, Nédio et al. Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique. PLoS ONE, v. 17, n. 4, p. 1-12, 28 Apr. 2022. |
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https://arca.fiocruz.br/handle/icict/54586 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0267472 |
| dc.identifier.eissn.none.fl_str_mv |
1932-6203 |
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MABUNDA, Nédio et al. Nucleic acid testing identifies high prevalence of blood borne viruses among approved blood donors in Mozambique. PLoS ONE, v. 17, n. 4, p. 1-12, 28 Apr. 2022. 1932-6203 10.1371/journal.pone.0267472 |
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Public Library of Science |
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Public Library of Science |
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