Growth hormone modulates migration of thymocytes and peripheral T cells

Bibliographic Details
Main Author: Savino, Wilson
Publication Date: 2012
Other Authors: Smaniotto, Salete, Cruz, Daniella Arêas Mendes da, Dardenne, Mireille
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/j.1749-6632.2012.06637.x
Download full: https://arca.fiocruz.br/handle/icict/15758
Summary: 2020-01-01
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spelling Savino, WilsonSmaniotto, SaleteCruz, Daniella Arêas Mendes daDardenne, Mireille2016-09-12T16:46:29Z2016-09-12T16:46:29Z2012SAVINO, Wilson; et al. Growth hormone modulates migration of thymocytes and peripheral T cells. Annals of the New York Academy of Sciences, v.12621, n.1, p.49-54, 2012.0077-8923https://arca.fiocruz.br/handle/icict/1575810.1111/j.1749-6632.2012.06637.xengWiley Online LibraryHormônio do CrescimentoTimócitosMovimento CelularIntegrinasQuimiocinasLinfonodosGrowth hormoneThymocitesCell migrationIntegrinsChemokinesLymph nodesGrowth hormone modulates migration of thymocytes and peripheral T cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Imunohistologia. Maceió, AL, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil / Université Paris Descartes. CNRS UMR-8147. Paris, France.In the context of immunoneuroendocrine cross talk, growth hormone (GH) exerts pleiotropic effects in the immune system. For example, GH-transgenic mice, as well as animals and humans treated with GH, exhibit enhanced cellularity in the thymus. GH also stimulates the thymic microenvironment, augmenting chemokine and extracellular matrix (ECM) production, with consequent increase in ECM- and chemokine-driven thymocyte migratory responses. Peripheral T cell migration triggered by laminin or fibronectin was enhanced in cells from GH-transgenic versus wild-type control adult mice, as seen for CD4(+) and CD8(+) T cells from mesenteric lymph nodes. Migration of these T lymphocytes, triggered by the chemokine CXCL12, in conjunction with laminin or fibronectin, was also enhanced compared with control counterparts. Considering that GH can be used as an adjuvant therapy in immunodeficiencies, including AIDS, the concepts defined herein, that GH enhances developing and peripheral T cell migration, provide new clues for future GH-related immune interventions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/68944c65-5a65-405a-94cb-4320db798236/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALwilson_savino_etal_IOC_2012.pdfwilson_savino_etal_IOC_2012.pdfapplication/pdf742865https://arca.fiocruz.br/bitstreams/5c702bcb-07f3-4a01-baab-4378bde32cf4/downloade73408deb26dcef858d69d18757238adMD52trueAnonymousREAD2020-01-01TEXTwilson_savino_etal_IOC_2012.pdf.txtwilson_savino_etal_IOC_2012.pdf.txtExtracted texttext/plain22642https://arca.fiocruz.br/bitstreams/c51228a4-2bc2-4345-8219-1ff54ad78d75/downloada8ba4fc547fbc816f4e81edc1abc8d11MD59falseAnonymousREAD2020-01-01THUMBNAILwilson_savino_etal_IOC_2012.pdf.jpgwilson_savino_etal_IOC_2012.pdf.jpgGenerated Thumbnailimage/jpeg41093https://arca.fiocruz.br/bitstreams/f8419468-bb12-487b-888b-8ea2d3bb78de/download5a113ca931e22189aa75e1a28892b260MD510falseAnonymousREAD2020-01-01icict/157582025-12-11 08:17:39.596open.accessoai:arca.fiocruz.br:icict/15758https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-11T11:17:39Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Growth hormone modulates migration of thymocytes and peripheral T cells
title Growth hormone modulates migration of thymocytes and peripheral T cells
spellingShingle Growth hormone modulates migration of thymocytes and peripheral T cells
Savino, Wilson
Hormônio do Crescimento
Timócitos
Movimento Celular
Integrinas
Quimiocinas
Linfonodos
Growth hormone
Thymocites
Cell migration
Integrins
Chemokines
Lymph nodes
title_short Growth hormone modulates migration of thymocytes and peripheral T cells
title_full Growth hormone modulates migration of thymocytes and peripheral T cells
title_fullStr Growth hormone modulates migration of thymocytes and peripheral T cells
title_full_unstemmed Growth hormone modulates migration of thymocytes and peripheral T cells
title_sort Growth hormone modulates migration of thymocytes and peripheral T cells
author Savino, Wilson
author_facet Savino, Wilson
Smaniotto, Salete
Cruz, Daniella Arêas Mendes da
Dardenne, Mireille
author_role author
author2 Smaniotto, Salete
Cruz, Daniella Arêas Mendes da
Dardenne, Mireille
author2_role author
author
author
dc.contributor.author.fl_str_mv Savino, Wilson
Smaniotto, Salete
Cruz, Daniella Arêas Mendes da
Dardenne, Mireille
dc.subject.other.none.fl_str_mv Hormônio do Crescimento
Timócitos
Movimento Celular
Integrinas
Quimiocinas
Linfonodos
topic Hormônio do Crescimento
Timócitos
Movimento Celular
Integrinas
Quimiocinas
Linfonodos
Growth hormone
Thymocites
Cell migration
Integrins
Chemokines
Lymph nodes
dc.subject.en.none.fl_str_mv Growth hormone
Thymocites
Cell migration
Integrins
Chemokines
Lymph nodes
description 2020-01-01
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-12T16:46:29Z
dc.date.available.fl_str_mv 2016-09-12T16:46:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAVINO, Wilson; et al. Growth hormone modulates migration of thymocytes and peripheral T cells. Annals of the New York Academy of Sciences, v.12621, n.1, p.49-54, 2012.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/15758
dc.identifier.issn.none.fl_str_mv 0077-8923
dc.identifier.doi.none.fl_str_mv 10.1111/j.1749-6632.2012.06637.x
identifier_str_mv SAVINO, Wilson; et al. Growth hormone modulates migration of thymocytes and peripheral T cells. Annals of the New York Academy of Sciences, v.12621, n.1, p.49-54, 2012.
0077-8923
10.1111/j.1749-6632.2012.06637.x
url https://arca.fiocruz.br/handle/icict/15758
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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