Overview of the therapeutic potential of piplartine (piperlongumine)

Bibliographic Details
Main Author: Bezerra, Daniel Pereira
Publication Date: 2013
Other Authors: Pessoa, Claudia do Ó., Moraes Filho, Manoel Odorico de, Saker Neto, Nicolau, Silveira, Edilberto Rocha, Lotufo, Leticia Veras Costa
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.ejps.2012.12.003
Download full: https://arca.fiocruz.br/handle/icict/25943
Summary: Bezerra, Daniel Pereira. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Bezerra, Daniel PereiraPessoa, Claudia do Ó.Moraes Filho, Manoel Odorico deSaker Neto, NicolauSilveira, Edilberto RochaLotufo, Leticia Veras Costa2018-04-19T12:54:21Z2018-04-19T12:54:21Z2013BEZERRA, D. P. et al. Overview of the therapeutic potential of piplartine (piperlongumine). European Journal of Pharmaceutical Sciences, v. 48, p. 453–463, 2013.0928-0987https://arca.fiocruz.br/handle/icict/2594310.1016/j.ejps.2012.12.003Bezerra, Daniel Pereira. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Capes (Coordenadoria de Apoio à Pesquisa e Ensino Superior), CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnológico), and Fapitec/SE (Fundação de Amparo à Pesquisa e à Inovação Tecnológica do Estado de Sergipe)Universidade Federal de Sergipe. Departamento de Fisiologia. São Cristóvão, SE, BrasilUniversidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza, CE, BrasilUniversidade Federal do Ceará. Faculdade de Medicina. Departamento de Fisiologia e Farmacologia. Fortaleza, CE, BrasilPiplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone) is a biologically active alkaloid/amide from peppers, as from long pepper (Piper longum L. - Piperaceae). Long pepper is one of the most widely used in Ayurvedic medicine, which is used to treat many diseases, including tumors. The purpose of the current paper is to address to the chemical structure establishment and to systematically survey the published articles and highlight recent advances in the knowledge of the therapeutic potential of piplartine, establishing new goals for future research. The reported pharmacological activities of piplartine include cytotoxic, genotoxic, antitumor, antiangiogenic, antimetastatic, antiplatelet aggregation, antinociceptive, anxiolytic, antidepressant, anti-atherosclerotic, antidiabetic, antibacterial, antifungal, leishmanicidal, trypanocidal, and schistosomicidal activities. Among the multiple pharmacological effects of piplartine, its anticancer property is the most promising. Therefore, the preclinical anticancer potential of piplartine has been extensively investigated, which recently resulted in one patent. This compound is selectively cytotoxic against cancer cells by induction of oxidative stress, induces genotoxicity, as an alternative strategy to killing tumor cells, has excellent oral bioavailability in mice, inhibits tumor growth in mice, and presents only weak systemic toxicity. In summary, we conclude that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials.engElsevierPiplartinePiperlonguminePimenta longaPiperaceaeMedicina ayurvédicaPiplartinePiperlongumineLong pepperPiperaceaeAyurvedic medicineOverview of the therapeutic potential of piplartine (piperlongumine)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/7497979d-783d-40f7-bf49-66290450c187/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALBezerra DP Overview of the therapeutic....pdfBezerra DP Overview of the therapeutic....pdfapplication/pdf368488https://arca.fiocruz.br/bitstreams/92650480-f62b-409e-85fb-280c65f03401/downloadd68431d6ac4cf73ed28ce8eb2ebf6908MD52trueAnonymousREADTEXTBezerra DP Overview of the therapeutic....pdf.txtBezerra DP Overview of the therapeutic....pdf.txtExtracted texttext/plain73450https://arca.fiocruz.br/bitstreams/c11f3155-ff2f-4dc6-8cff-31e52becb68d/download0f0d1474fafa8e2fd970e55b461892c8MD55falseAnonymousREADTHUMBNAILBezerra DP Overview of the therapeutic....pdf.jpgBezerra DP Overview of the therapeutic....pdf.jpgGenerated Thumbnailimage/jpeg5621https://arca.fiocruz.br/bitstreams/81745b0b-666f-4fec-9b2e-5149f57a65a9/downloada49b1b911e3f44c74a65fb63b7e977eeMD56falseAnonymousREADicict/259432025-07-29 21:06:33.144open.accessoai:arca.fiocruz.br:icict/25943https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T00:06:33Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Overview of the therapeutic potential of piplartine (piperlongumine)
title Overview of the therapeutic potential of piplartine (piperlongumine)
spellingShingle Overview of the therapeutic potential of piplartine (piperlongumine)
Bezerra, Daniel Pereira
Piplartine
Piperlongumine
Pimenta longa
Piperaceae
Medicina ayurvédica
Piplartine
Piperlongumine
Long pepper
Piperaceae
Ayurvedic medicine
title_short Overview of the therapeutic potential of piplartine (piperlongumine)
title_full Overview of the therapeutic potential of piplartine (piperlongumine)
title_fullStr Overview of the therapeutic potential of piplartine (piperlongumine)
title_full_unstemmed Overview of the therapeutic potential of piplartine (piperlongumine)
title_sort Overview of the therapeutic potential of piplartine (piperlongumine)
author Bezerra, Daniel Pereira
author_facet Bezerra, Daniel Pereira
Pessoa, Claudia do Ó.
Moraes Filho, Manoel Odorico de
Saker Neto, Nicolau
Silveira, Edilberto Rocha
Lotufo, Leticia Veras Costa
author_role author
author2 Pessoa, Claudia do Ó.
Moraes Filho, Manoel Odorico de
Saker Neto, Nicolau
Silveira, Edilberto Rocha
Lotufo, Leticia Veras Costa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, Daniel Pereira
Pessoa, Claudia do Ó.
Moraes Filho, Manoel Odorico de
Saker Neto, Nicolau
Silveira, Edilberto Rocha
Lotufo, Leticia Veras Costa
dc.subject.other.none.fl_str_mv Piplartine
Piperlongumine
Pimenta longa
Piperaceae
Medicina ayurvédica
topic Piplartine
Piperlongumine
Pimenta longa
Piperaceae
Medicina ayurvédica
Piplartine
Piperlongumine
Long pepper
Piperaceae
Ayurvedic medicine
dc.subject.en.none.fl_str_mv Piplartine
Piperlongumine
Long pepper
Piperaceae
Ayurvedic medicine
description Bezerra, Daniel Pereira. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-04-19T12:54:21Z
dc.date.available.fl_str_mv 2018-04-19T12:54:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BEZERRA, D. P. et al. Overview of the therapeutic potential of piplartine (piperlongumine). European Journal of Pharmaceutical Sciences, v. 48, p. 453–463, 2013.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/25943
dc.identifier.issn.none.fl_str_mv 0928-0987
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejps.2012.12.003
identifier_str_mv BEZERRA, D. P. et al. Overview of the therapeutic potential of piplartine (piperlongumine). European Journal of Pharmaceutical Sciences, v. 48, p. 453–463, 2013.
0928-0987
10.1016/j.ejps.2012.12.003
url https://arca.fiocruz.br/handle/icict/25943
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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