Immune modulation in primary vaccinia virus zoonotic human infections

Bibliographic Details
Main Author: Gomes, Juliana de Assis Silva
Publication Date: 2012
Other Authors: Araújo, Fernanda Fortes de, Trindade, Giliane de Souza, Quinan, Bárbara Resende, Drumond, Betânia Paiva, Ferreira, Jaqueline Maria Siqueira, Mota, Bruno Eduardo Fernandes, Nogueira, Maurício Lacerda, Kroon, Erna Geessien, Abrahão, Jônatas Santos, Oliveira, Rodrigo Corrêa de, Fonseca, Flávio Guimarães da
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1155/2012/974067
Download full: https://arca.fiocruz.br/handle/icict/7954
Summary: FAPEMIG , CNPq, National Institute of Science and Technology in Vaccines
id CRUZ_869a8c8fb7567ee91bc71a3c64e4ad12
oai_identifier_str oai:arca.fiocruz.br:icict/7954
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Gomes, Juliana de Assis SilvaAraújo, Fernanda Fortes deTrindade, Giliane de SouzaQuinan, Bárbara ResendeDrumond, Betânia PaivaFerreira, Jaqueline Maria SiqueiraMota, Bruno Eduardo FernandesNogueira, Maurício LacerdaKroon, Erna GeessienAbrahão, Jônatas SantosOliveira, Rodrigo Corrêa deFonseca, Flávio Guimarães da2014-07-14T18:55:13Z2014-07-14T18:55:13Z2012GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067.1740-2522https://arca.fiocruz.br/handle/icict/795410.1155/2012/974067FAPEMIG , CNPq, National Institute of Science and Technology in VaccinesUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFaculdade de Medicina de São José do Rio Preto. Departamento de Doenças Infecciosas e Parasitárias. São José do Rio Preto, SP, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilIn 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4+ cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages. Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humansengHindawi Publishing CorporationImmune modulation in primary vaccinia virus zoonotic human infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCD4-Positive T-LymphocytesAntigensImmunity, CellularLymphocyte Activationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALImmune modulation in primary vaccinia virus zoonotic human infections.pdfImmune modulation in primary vaccinia virus zoonotic human infections.pdfapplication/pdf1702515https://arca.fiocruz.br/bitstreams/a862a42d-7199-4d5a-a8c2-1e3ac709ffab/downloadede11f61d3e10b7c1b97a5477f3f12deMD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://arca.fiocruz.br/bitstreams/fcb8cdc2-c0b6-494c-a1e7-38b742755fb3/download7d48279ffeed55da8dfe2f8e81f3b81fMD52falseAnonymousREADTEXTImmune modulation in primary vaccinia virus zoonotic human infections.pdf.txtImmune modulation in primary vaccinia virus zoonotic human infections.pdf.txtExtracted texttext/plain51857https://arca.fiocruz.br/bitstreams/0919622e-30f8-4924-bc71-d464fc2feb4a/downloadba97f7ccd08c923e6dadca972263c823MD55falseAnonymousREADTHUMBNAILImmune modulation in primary vaccinia virus zoonotic human infections.pdf.jpgImmune modulation in primary vaccinia virus zoonotic human infections.pdf.jpgGenerated Thumbnailimage/jpeg5332https://arca.fiocruz.br/bitstreams/f5f07795-1bd9-4e35-b0e4-b051f2a67238/download4a1c46d002e5903a5aca48066522f252MD56falseAnonymousREADicict/79542025-07-30 01:14:34.724open.accessoai:arca.fiocruz.br:icict/7954https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:14:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Immune modulation in primary vaccinia virus zoonotic human infections
title Immune modulation in primary vaccinia virus zoonotic human infections
spellingShingle Immune modulation in primary vaccinia virus zoonotic human infections
Gomes, Juliana de Assis Silva
CD4-Positive T-Lymphocytes
Antigens
Immunity, Cellular
Lymphocyte Activation
title_short Immune modulation in primary vaccinia virus zoonotic human infections
title_full Immune modulation in primary vaccinia virus zoonotic human infections
title_fullStr Immune modulation in primary vaccinia virus zoonotic human infections
title_full_unstemmed Immune modulation in primary vaccinia virus zoonotic human infections
title_sort Immune modulation in primary vaccinia virus zoonotic human infections
author Gomes, Juliana de Assis Silva
author_facet Gomes, Juliana de Assis Silva
Araújo, Fernanda Fortes de
Trindade, Giliane de Souza
Quinan, Bárbara Resende
Drumond, Betânia Paiva
Ferreira, Jaqueline Maria Siqueira
Mota, Bruno Eduardo Fernandes
Nogueira, Maurício Lacerda
Kroon, Erna Geessien
Abrahão, Jônatas Santos
Oliveira, Rodrigo Corrêa de
Fonseca, Flávio Guimarães da
author_role author
author2 Araújo, Fernanda Fortes de
Trindade, Giliane de Souza
Quinan, Bárbara Resende
Drumond, Betânia Paiva
Ferreira, Jaqueline Maria Siqueira
Mota, Bruno Eduardo Fernandes
Nogueira, Maurício Lacerda
Kroon, Erna Geessien
Abrahão, Jônatas Santos
Oliveira, Rodrigo Corrêa de
Fonseca, Flávio Guimarães da
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Juliana de Assis Silva
Araújo, Fernanda Fortes de
Trindade, Giliane de Souza
Quinan, Bárbara Resende
Drumond, Betânia Paiva
Ferreira, Jaqueline Maria Siqueira
Mota, Bruno Eduardo Fernandes
Nogueira, Maurício Lacerda
Kroon, Erna Geessien
Abrahão, Jônatas Santos
Oliveira, Rodrigo Corrêa de
Fonseca, Flávio Guimarães da
dc.subject.en.none.fl_str_mv CD4-Positive T-Lymphocytes
Antigens
Immunity, Cellular
Lymphocyte Activation
topic CD4-Positive T-Lymphocytes
Antigens
Immunity, Cellular
Lymphocyte Activation
description FAPEMIG , CNPq, National Institute of Science and Technology in Vaccines
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-14T18:55:13Z
dc.date.available.fl_str_mv 2014-07-14T18:55:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/7954
dc.identifier.issn.none.fl_str_mv 1740-2522
dc.identifier.doi.none.fl_str_mv 10.1155/2012/974067
identifier_str_mv GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067.
1740-2522
10.1155/2012/974067
url https://arca.fiocruz.br/handle/icict/7954
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/a862a42d-7199-4d5a-a8c2-1e3ac709ffab/download
https://arca.fiocruz.br/bitstreams/fcb8cdc2-c0b6-494c-a1e7-38b742755fb3/download
https://arca.fiocruz.br/bitstreams/0919622e-30f8-4924-bc71-d464fc2feb4a/download
https://arca.fiocruz.br/bitstreams/f5f07795-1bd9-4e35-b0e4-b051f2a67238/download
bitstream.checksum.fl_str_mv ede11f61d3e10b7c1b97a5477f3f12de
7d48279ffeed55da8dfe2f8e81f3b81f
ba97f7ccd08c923e6dadca972263c823
4a1c46d002e5903a5aca48066522f252
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839716355807379456

Similar Items